Emergence of Usutu Virus in Hungary

Bakonyi, Tamás; Erdélyi, Károly; Ursu, Krisztina; Ferenczi, Emöke; Csörgő, Tibor; Lussy, Helga; Chvala, S.; Bukovsky, C.; Meister, Tanja; Weissenböck, Herbert; Nowotny, Norbert

doi:10.1128/jcm.01390-07

Cited by 138 publications

(132 citation statements)

References 16 publications

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“…USUV is also a member of the genus Flavivirus and the Japanese encephalitis serocomplex [41]. In Europe, USUV emerged in Austria in 2001 [42] and outbreaks have also been reported in Hungary [43], in Switzerland, in Italy [44], in Spain [45], and in Germany [46]. The detection of neutralizing antibodies against USUV in our WNV surveillance system is similar to findings in Northern Italy, where antibodies against USUV were detected in sentinel animals tested within the framework of the WNV surveillance system, providing evidence of co-circulation of WNV and USUV in the same area [47].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a West Nile virus surveillance and early warning system in Greece, based on domestic pigeons

Chaintoutis¹,

Dovas²,

Papanastassopoulou³

et al. 2014

Comparative Immunology, Microbiology and Infectious Diseases

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a b s t r a c tIn the summer of 2010 an epidemic of West Nile virus (WNV) occurred in Central Macedonia, Greece, with 197 human neuroinvasive disease (WNND) cases. In the following years the virus spread to new areas, with a total of 76 WNND cases in 2011, and 109 WNND cases in 2012 (14 and 12 WNND cases, respectively, in Central Macedonia). We established a surveillance system based on serological testing of domestic pigeons, using cELISA confirmed by serum neutralization test. In Central Macedonia, pigeon seroprevalence was 54% (95% CI: 49-59%) and 31% (95% CI: 24-37%) at the end of the 2010 and 2011 epidemic seasons, respectively. One serum was positive for neutralizing antibodies directed against Usutu virus. Pigeon WNV seroprevalence and incidence rates of human WNND after the 2010 epidemic were positively correlated ( = 0.94, at the regional unit level), while in 2011 the correlation ( = 0.56) was not statistically significant, possibly due to small number of human WNND cases recorded. To evaluate the efficacy of the system at alerting upon WNV enzootic circulation before the onset of human cases, we tested 270 pigeons in 2011 and 240 pigeons in 2012. In Central Macedonia, the first seroconversions in pigeons were recorded 44 and 47 days, respectively, before the first human WNND cases. Pigeon surveillance was used successfully for identification of areas with WNV enzootic transmission and for early warning. Timely diffusion of information to health authorities facilitated the implementation of preparedness plans to protect public health.

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Section: Discussionmentioning

confidence: 99%

Evaluation of a West Nile virus surveillance and early warning system in Greece, based on domestic pigeons

Chaintoutis¹,

Dovas²,

Papanastassopoulou³

et al. 2014

Comparative Immunology, Microbiology and Infectious Diseases

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“…In den folgenden Jahren wurde zunehmend über USUV-Infektionen in Europa bei wild lebenden und in Gefangenschaft gehaltenen Vögeln berichtet ( [10,30,32,35,36] [48]. USUV-Antikörper wurden auch bei einem Pferd in Serbien nachgewiesen [42].…”

Section: Epidemiologieunclassified

“…Jahrhunderts in Europa ausbreitet. Die meisten Todesfäl-le in Zentraleuropa wurden bei Amseln (Turdus merula) beobachtet, jedoch wurden auch Todesfälle bei anderen Vogelspezies beobachtet [10,30,35,36]. Seroepidemiologische Untersuchungen von einer Vielzahl von Vögeln belegen zudem, dass einzelne Spezies sich zwar in-fizieren können, jedoch nicht erkranken oder die Infektion überstehen.…”

Section: Epidemiologieunclassified

“…verschiedenen Genomabschnitten zeigen, dass in Europa unterschiedliche, aber eng verwandte Varianten zirkulieren [10,35,40,47,50] …”

Section: Epidemiologieunclassified

“…In Ungarn wurde USUV aus toten Vö-geln auf embryonalen Gänsefibroblas-ten und in Italien sowie Deutschland auf Verozellen isoliert [10,35,47]. Erfolgreiche Isolierung von USUV aus Mücken in C6/36-Zellen berichteten Jöst et al [39], während die Isolierung von USUV aus einem PCR-positiven Mückenpool auf Verozellen in Spanien negativ verlief [41].…”

Section: Serologischer Nachweisunclassified

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