Emergence of the silicon human and network targeting drugs

Activation of the Farnesoid X-receptor in breast cancer cell lines results in cytotoxicity but not increased migration potential

“…These related concepts exploit the greater understanding of network biology to predict synergistic combination therapies [5].…”

Can a systems approach produce a better understanding of mood disorders?

“…In addition, they are increasingly used to the understand aberrant behaviour of these systems (i.e. disease states), helping identify novel therapeutic options [7,8]. It could be argued that this approach is of particular importance for the examination of complex biological phenomenon such as 4 mood.…”

“…In these cases, we usually define a system as a lower level of organisation, such as an organ or cell, or even an individual sub-compartment of the cell. Robustly reconstructing these individual components, will allow their merging to create larger structures, eventually leading to the in silico human [8].…”

“…The aim of systems biology is to predict the emergent biological phenotype from the interactions that occur within a system [8].…”

SupraBiology 2014: Promoting UK‐China collaboration on Systems Biology and High Performance Computing

“…To achieve such goal one line of research consists of creating a "person simulator" [3] able to produce a virtual twin of the patient, based on multiple biomarkers subject to individual variability. Such a virtual twin would then be used to predict and test in silico an array of drugs designed to elicit in the patient the desired effect.…”