Emergence of TCF7L2 as a Most Promising Gene in Predisposition of Diabetes Type II

Gupta, Vipin; Khadgawat, Rajesh; Saraswathy, Kallur Nava; Sachdeva, M.P.; Kalla, A.K.

doi:10.1080/09723757.2008.11886031

Cited by 14 publications

(7 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been postulated that TCF7L2 gene variants may confer susceptibility to T2DM indirectly by altering GLP-1 levels [51]. It was predicted that in the carriers of TCF7L2 risk alleles, the Wnt signaling is potentially increased and thereby the pre-adipocytes are not differentiated into the mature adipocytes and probably influence the growth and development of adipose tissue and alter BMI [51], [52]. Thus TCF7L2 might play some role in the adipogenesis resulting in the deposition of triglycerides in peripheral tissues leading to insulin resistance [20].…”

Section: Discussionmentioning

confidence: 99%

Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Hyderabad, India

et al. 2013

View full text Add to dashboard Cite

We attempt to evaluate the nature of association of TCF7L2 gene variants with T2DM, for the first time in the population of Hyderabad, which is considered to be diabetic capital of India. It is a case-control study of the three SNPs of TCF7L2, rs7903146, rs12255372 and rs11196205, genotyped on Sequenom Massarray platform, in a sample of 758 patients and 621 controls. The risk allele frequency of the three SNPs was found to be significantly higher in the T2DM cases than controls, implicating susceptibility for diabetes (p<0.01). The greatest risk of developing the disease was conferred by rs7903146. Further, the logistic regression of genotypes of each SNP under log additive model, and the haplotypes constituted by at least one of the three risk alleles also show significantly greater risk of developing T2DM when compared to the wild type haplotype. Further, BMI and WHR emerge as significant covariates with confounding effects. The strong association of the TCF7L2 SNPs with T2DM is consistent with the findings among other Indian and Non-Indian populations, suggesting universal phenomena of its association across ethnic groups globally, both within and outside the Indian subcontinent, albeit the functional relevance of these SNPs needs yet to be established.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Hyderabad, India

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Its pathogenesis appears to involve complex interactions between genetic predisposition and environmental factors. [3] T2DM occurs when impaired insulin resistance is accompanied by the failure to produce ample amount of β-cell insulin. [4] Evidences suggest that premature detection of diabetes by suitable screening method, especially in subjects with elevated risk for diabetes will help to intercept or delay the vascular complications and thus reduce the clinical, social and economic burden of the disease.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Risk of Type 2 Diabetes Mellitus in Medical Students Using Indian Diabetes Risk Score (IDRS)

2020

IJOP

View full text Add to dashboard Cite

Background: Diabetes as a non-communicable disease is significant public health problem all over the world. Type 2 Diabetes Mellitus (T2DM) is a disease that develops slowly and over time and only recently has it become evident that T2DM finds its presence even among the younger age groups. Therefore a cross sectional study has been conducted to evaluate and assess the risk for developing T2DM among undergraduate students using Indian Diabetes Risk Score(IDRS), a questionnaire that is simple, validated and has proven to be highly effective in previous studies.Objectives: To evaluate the risk of developing diabetes among medical students using Indian Diabetes Risk score. Method:The study included 100 MBBS students. Detailed history was taken which includes information regarding their age, family history of diabetes and exercise. Waist circumference was measured .Risk of diabetes was calculated using Indian Diabetes Risk Score.Results: Risk of developing diabetes was high in 6%, moderate in 87.3% and low in 9.7% of students. Conclusion:Risk of diabetes was present in more than 50% of medical students as assessed by Indian Diabetes Risk Score.

show abstract

“…Clearly, T2DM has become an epidemic in the 21st century with India leading the world with the largest number of diabetic subjects. Type 2 diabetes mellitus is a non autoimmune, complex, heterogeneous and polygenic metabolic disease in which the body fails to produce enough insulin, characterized by abnormal glucose homeostasis [ 2 ]. Its pathogenesis appears to involve complex interactions between genetic and environmental factors [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Type 2 diabetes mellitus is a non autoimmune, complex, heterogeneous and polygenic metabolic disease in which the body fails to produce enough insulin, characterized by abnormal glucose homeostasis [ 2 ]. Its pathogenesis appears to involve complex interactions between genetic and environmental factors [ 2 ]. Identification of the genetic components of T2DM is the most important area of diabetes research because elucidation of the diabetes genes (alleles) will influence all efforts toward a mechanistic understanding of the disease, its complications, and its treatment, cure, and prevention [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Glutathione-S-Transferase (GSTM1 and GSTT1) and FTO Gene Polymorphisms with Type 2 Diabetes Mellitus Cases in Northern India

Raza

Abbas

Ahmad

et al. 2014

Balkan Journal of Medical Genetics

View full text Add to dashboard Cite

Type 2 diabetes mellitus (T2DM) is growing in an epidemic manner across the world and India has the world’s largest number of diabetic subjects. The present study was carried out to investigate the association of glutathione-S-transferase (GSTM1, GSTT1) and fat mass and obesity associated (FTO) gene polymorphisms with T2DM patients and controls, and its role in increasing the susceptibility to T2DM. A total of 198 subjects (101 T2DM patients and 97 controls) participated in this study. GSTM1, GSTT1 and FTO gene polymorphisms in the patients and controls were evaluated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). We observed significant association of GSTM1 positive (p = 0.046) and GSTM1 null (p = 0.046) genotypes with T2DM, while no significant association was found with the FTO gene polymorphism in our study. It seems that the GSTM1 gene polymorphism can be a predictive marker for early identification of a population at risk of T2DM. The potential role of GST and FTO gene polymorphisms as a marker of susceptibility to T2DM needs further studies in a larger number of patients.

show abstract

Emergence of TCF7L2 as a Most Promising Gene in Predisposition of Diabetes Type II

Cited by 14 publications

References 27 publications

Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Hyderabad, India

Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Hyderabad, India

Evaluation of Risk of Type 2 Diabetes Mellitus in Medical Students Using Indian Diabetes Risk Score (IDRS)

Association of Glutathione-S-Transferase (GSTM1 and GSTT1) and FTO Gene Polymorphisms with Type 2 Diabetes Mellitus Cases in Northern India

Contact Info

Product

Resources

About