Emergence of SARS-CoV-2 variant of concern omicron: biological features and genomic concern

Abstract

Corona virus infection is a worldwide health threat that has infected a substantial portion of the world’s population and is caused by SARS-CoV-2. It is the natural tendency of a virus to change the genetic makeup through point mutation, and such viruses are called variant of the original virus. The SARS-CoV-2 virus also undergoes such mutation (maybe one or more and distinct from other) over time and many genetically diverse variant has risen. Such variants might be variants of concern (VOC) and variants of interest (VOI) based on the differences in virulence, transmissibility, pathogenicity, and vaccination efficacy. Omicron, a new VOC of SARS-CoV-2, has recently emerged as global distress to more than 115 countries. The article provides a summary of the evolutionary, biological, and genomic aspects of different SARS-CoV-2 VOC with respect to Omicron and found that amino acid mutation in spike proteins such as A67V, ∆69-70, Q954H, N969K, L981F etc and other structural protein mutations such as D3G, Q19E, A63T in membrane protein, T9I in envelope protein and P13L, ∆31-33, R203K, G204R in nucleocapsid protein results major differences between different VOC/VOI of SARS-CoV-2. Further, the effectiveness of the widely used SARS-CoV-2 vaccines has been reviewed specific to Omicron. The existing available Covid-19 vaccines developed and manufactured by Pfizer, AstraZeneca, Johnson & Johnson, Moderna, and Novavax show reduced efficacy against the latest VOC of SARS-CoV-2 Omicron. Based on the available literature of preliminary findings, people who get a booster shot or a third vaccine dosage may have better protected against Omicron.

Influence of variants mutations on the progression and outcome of COVID-19 in Pakistan

“…The Omicron variant has additional spike protein mutations, the majority of which occur in the receptor binding site. These mutations boost the variant's transmissibility while reducing the response to antibodies and vaccinations (27). MODE OF TRANSMISSION SARS-CoV-2 utilized an integrative approach to propagate from the beginning.…”