1973
DOI: 10.1038/244173a0
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Emergence of Rifampin-resistance in Chlamydia trachomatis

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1975
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Cited by 56 publications
(16 citation statements)
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“…Long-term treatment of in vitro chlamydial infection, however, resulted in the emergence of resistance. This observation is in agreement with previous data published by Keshishyan (26) found that resistance to rifampin developed rather easily during passage in chlamydia-infected egg yolk sacs. This observation has since been confirmed in tissue culture systems (23,51,57).…”
Section: Vol 45 2001 Effects Of Azithromycin and Rifampin On C Trasupporting
confidence: 83%
“…Long-term treatment of in vitro chlamydial infection, however, resulted in the emergence of resistance. This observation is in agreement with previous data published by Keshishyan (26) found that resistance to rifampin developed rather easily during passage in chlamydia-infected egg yolk sacs. This observation has since been confirmed in tissue culture systems (23,51,57).…”
Section: Vol 45 2001 Effects Of Azithromycin and Rifampin On C Trasupporting
confidence: 83%
“…Relative resistance of C. trachomatis to erythromycin in vitro has been noted (10), and erythromycin stearate given in 250-mg doses four times daily for 7 days resulted in frequent failure to eradicate C. trachomatis from men with nongonococcal urethritis (W. R. Bowie, unpublished data). Resistance to rifampin is easily produced in vitro (8), and there is concern about resistance arising in vivo.…”
mentioning
confidence: 99%
“…Rifampin and other rifamycins have been known for over 30 years to be very active in vitro against C. trachomatis and C. pneumoniae, with MICs ranging from 0.0075 to 0.03 g/ml (7,8,10,11). However, as early as 1973, Keshishyan et al (8) demonstrated rapid single-step emergence of resistance to rifampin in C. trachomatis in eggs.…”
mentioning
confidence: 99%
“…However, as early as 1973, Keshishyan et al (8) demonstrated rapid single-step emergence of resistance to rifampin in C. trachomatis in eggs. Similar results were also obtained in tissue culture (11).…”
mentioning
confidence: 99%
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