Emergence of OXA-48-producing Escherichia coli in the Caribbean islands

Breurec, Sébastien; Bastian, Sylvaine; Cuzon, Gaëlle; Bernabeu, Sandrine; Foucan, Tania; Galanth, S.; Naas, Thierry; Dortet, Laurent

doi:10.1016/j.jgar.2015.04.004

Cited by 6 publications

(6 citation statements)

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“…WGS also confirmed the presence of carbapenemase-producing ECC (GENC133) in Guadeloupe (Fig. 1), where carbapenemase-producing Enterobacteriaceae emerged in 2014 (29,30). The isolate collected from a human sample in September 2018 belonged to ST114, and its genetic background was shown to be the major ECC clade A clone in a previous study of carbapenemase producers (5).…”

Section: Dissemination Of Esbl-producing Ecc From Hospital To Wwtpsupporting

confidence: 67%

Dissemination of Extended-Spectrum-β-Lactamase-Producing Enterobacter cloacae Complex from a Hospital to the Nearby Environment in Guadeloupe (French West Indies): ST114 Lineage Coding for a Successful IncHI2/ST1 Plasmid

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Guyomard-Rabenirina

Couvin

et al. 2021

Antimicrob Agents Chemother

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Wastewater treatment plants are considered hotspots for antibiotic resistance. Most studies have addressed the impact on the aquatic environment, as water is an important source of anthropogenic pollutants. Few investigations have been conducted on terrestrial animals living near treatment ponds. We isolated extended-spectrum beta-lactamase Enterobacter cloacae complex-producing strains from 35 clinical isolates, 29 samples of wastewater, 19 wild animals, and 10 domestic animals living in the hospital sewers and at or near a wastewater treatment plant to study the dissemination of clinically relevant resistance through hospital and urban effluents. After comparison of the antibiotic resistant profiles of E. cloacae complex strains, a more detailed analysis of 41 whole-genome-sequenced strains demonstrated that the most common sequence type, ST114 (n=20), was present in human (n=9) and non-human (n=11) samples, with a close genetic relatedness. Whole-genome sequencing confirmed local circulation of this pathogenic lineage in diverse animal species. In addition, nanopore sequencing and specific synteny of an IncHI2/ST1/blaCTX-M-15 plasmid recovered on the majority of these ST114 clones (n=18) indicated successful worldwide diffusion of this mobile genetic element.

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Section: Dissemination Of Esbl-producing Ecc From Hospital To Wwtpsupporting

confidence: 67%

Dissemination of Extended-Spectrum-β-Lactamase-Producing Enterobacter cloacae Complex from a Hospital to the Nearby Environment in Guadeloupe (French West Indies): ST114 Lineage Coding for a Successful IncHI2/ST1 Plasmid

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Guyomard-Rabenirina

Couvin

et al. 2021

Antimicrob Agents Chemother

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“…We did not isolate any carbapenemase-producing strains, although these strains have been observed in the community, even in low prevalence countries such as England [ 15 ] where their presence is often related to travel in Asia where these strains are endemic [ 35 ]. In Guadeloupe, Enterobacteriaceae carbapenemase-producing strains have just begun to emerge in hospital settings with the first description of an NDM-1-producing K. pneumoniae in 2014 [ 36 ], and more recently, of an OXA-48-producing E. coli [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Temporal trends and risks factors for antimicrobial resistant Enterobacteriaceae urinary isolates from outpatients in Guadeloupe

et al. 2016

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BackgroundUrinary tract infections are bacterial infections most commonly encountered in the community. The resistance rate of uropathogens to commonly prescribed antibiotics has increased worldwide but there are no published data concerning the resistance of strains isolated from community-acquired UTI in Guadeloupe. To assess the susceptibility patterns of Enterobacteriaceae strains isolated from outpatients in Guadeloupe we conducted a prospective study from December 2012 to May 2014 among outpatients consulting at private and public laboratories for urine analysis. Risk factors for E. coli resistance to amoxicillin, third-generation cephalosporin, and ciprofloxacin were also determined. To study the trends of E. coli resistance rates over the past 10 years, data on the susceptibility patterns of E. coli from 2003 to 2014 were also collected from three major laboratories for a retrospective study.ResultsDuring the prospective study, we isolated 1293 bacterial strains from the urine of outpatients presenting for urine analysis. The most commonly isolated bacteria were E. coli (57 %) and Klebsiella pneumoniae (15.5 %). Thirty seven per cent of the E. coli strains were resistant to amoxicillin. Resistance rates to third generation cephalosporin were low for E. coli and other Enterobacteriaceae (3.1 and 12.2 % respectively) and mostly due to the presence of an Extended Spectrum Beta-lactamase. Resistance to cotrimoxazole and ciprofloxacin was moderate (17.8 and 15.6 % respectively). However, the resistance rate of E. coli to ciprofloxacin has significantly increased during the last 10 years. Risk factors were consistent with previously reported data, especially for the increasing ciprofloxacin resistance with age.ConclusionGeneral practitioners in Guadeloupe need to be better informed to favor the prescription of fosfomycin-trometamol to reduce the risk of resistance to fluoroquinolones.

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“…Currently, Enterobacterales with bla OXA-48 have a truly global distribution, and reports of imported and nonimported cases have described from all continents except Antarctica, including the Americas (e.g., Colombia [100] and Mexico [91]), various European and North American countries (69), Sub-Saharan Africa (e.g., Tanzania [101], South Africa [97], and Senegal [60]), Asia (e.g., Japan [102], Singapore [103], Taiwan [104], and Malaysia [105]), Oceania (e.g., New Zealand [106]), and the Caribbean islands (107).…”

Section: Geographical Distribution Of Oxa-48mentioning

confidence: 99%

The Global Ascendency of OXA-48-Type Carbapenemases

et al. 2019

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SUMMARY Surveillance studies have shown that OXA-48-like carbapenemases are the most common carbapenemases in Enterobacterales in certain regions of the world and are being introduced on a regular basis into regions of nonendemicity, where they are responsible for nosocomial outbreaks. OXA-48, OXA-181, OXA-232, OXA-204, OXA-162, and OXA-244, in that order, are the most common enzymes identified among the OXA-48-like carbapenemase group. OXA-48 is associated with different Tn1999 variants on IncL plasmids and is endemic in North Africa and the Middle East. OXA-162 and OXA-244 are derivatives of OXA-48 and are present in Europe. OXA-181 and OXA-232 are associated with ISEcp1, Tn2013 on ColE2, and IncX3 types of plasmids and are endemic in the Indian subcontinent (e.g., India, Bangladesh, Pakistan, and Sri Lanka) and certain sub-Saharan African countries. Overall, clonal dissemination plays a minor role in the spread of OXA-48-like carbapenemases, but certain high-risk clones (e.g., Klebsiella pneumoniae sequence type 147 [ST147], ST307, ST15, and ST14 and Escherichia coli ST38 and ST410) have been associated with the global dispersion of OXA-48, OXA-181, OXA-232, and OXA-204. Chromosomal integration of blaOXA-48 within Tn6237 occurred among E. coli ST38 isolates, especially in the United Kingdom. The detection of Enterobacterales with OXA-48-like enzymes using phenotypic methods has improved recently but remains challenging for clinical laboratories in regions of nonendemicity. Identification of the specific type of OXA-48-like enzyme requires sequencing of the corresponding genes. Bacteria (especially K. pneumoniae and E. coli) with blaOXA-48, blaOXA-181, and blaOXA-232 are emerging in different parts of the world and are most likely underreported due to problems with the laboratory detection of these enzymes. The medical community should be aware of the looming threat that is posed by bacteria with OXA-48-like carbapenemases.

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Emergence of OXA-48-producing Escherichia coli in the Caribbean islands

Cited by 6 publications

References 5 publications

Dissemination of Extended-Spectrum-β-Lactamase-Producing Enterobacter cloacae Complex from a Hospital to the Nearby Environment in Guadeloupe (French West Indies): ST114 Lineage Coding for a Successful IncHI2/ST1 Plasmid

Dissemination of Extended-Spectrum-β-Lactamase-Producing Enterobacter cloacae Complex from a Hospital to the Nearby Environment in Guadeloupe (French West Indies): ST114 Lineage Coding for a Successful IncHI2/ST1 Plasmid

Temporal trends and risks factors for antimicrobial resistant Enterobacteriaceae urinary isolates from outpatients in Guadeloupe

The Global Ascendency of OXA-48-Type Carbapenemases

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