Emergence of novel non-aggregative variants under negative frequency-dependent selection inKlebsiella variicola
Amandine Nucci,
Juliette Janaszkiewicz,
Eduardo P.C. Rocha
et al.
Abstract:Klebsiella variicola is an emergent human pathogen causing numerous diverse infections, including in the urinary tract. However, little is known about the evolution and maintenance of genetic diversity in this species, the molecular mechanisms and their population dynamics. Here, we characterized the emergence of a novel rdar-like morphotype which is contingent both on the genetic background and the environment. We show that mutations in either the nitrogen assimilation control gene (nac) or the type III fimbr… Show more
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