Emergence of methicillin-resistant Staphylococcus aureus as a community pathogen

Bukharie, Huda A.; Abdelhadi, Maha; Saeed, Ibrahim; Rubaish, Abdullah; Larbi, E.

doi:10.1016/s0732-8893(01)00242-5

Cited by 92 publications

(73 citation statements)

References 11 publications

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“…While the problems with HA-MRSA were not at their full width yet, a second phase in the history of MRSA dawned halfway the 1990s, when MRSA infections involving strains different from HA-MRSA were increasingly documented in non-hospitalized patients (79,80,81,82,83). Such cases, called Community-Associated or Community-Acquired MRSA (CA-MRSA), have since been reported worldwide.…”

Section: Mrsa: Methicillin-resistant S Aureusmentioning

confidence: 99%

Methicillin-resistantStaphylococcus aureus(MRSA) in food production animals

et al. 2010

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SummaryUntil recently, reports on MRSA in livestock were mainly limited to occasional detections in dairy cattle mastitis. Since 2005 however, studies show the existence of an MRSA clone, CC398, which has been reported colonizing pigs, veal calves and broiler chickens and infecting dairy cows. Many aspects of its prevalence in pigs are not yet understood. In other livestock, colonizing capacity and reservoir status are still unclear.. MRSA CC398 has also been detected in meat but, like for other MRSA, the risk this might pose is rather unclear. For now, the most worrying aspect of MRSA CC398 seems to be its capacity to spread to humans. This might complicate MRSA control measures in human healthcare, posing for urgent research into risk factors and transmission routes. Overall, infections with MRSA CC398 are much less reported than carriage. More investigation into its pathogenic potential is though required. Also the origin and evolution of this clone remain to be revealed.3

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Section: Mrsa: Methicillin-resistant S Aureusmentioning

confidence: 99%

Methicillin-resistantStaphylococcus aureus(MRSA) in food production animals

et al. 2010

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“…These infections were classified as community-acquired MRSA based on several factors: (1) none of the patients had risk factors for nosocomially acquired MRSA (ie, recent hospitalization or surgery 1 ) or those risk factors previously associated with acquisition of MRSA outside a short-term care setting: residence in a long-term care facility, current intravenous drug abuse, or underlying illnesses such as cardiovascular or pulmonary disease, diabetes mellitus, malignancy, or chronic skin disease such as eczema, 14 and (2) antimicrobial resistance patterns were consistent with CA-MRSA-ie, they showed susceptibility to several classes of antimicrobial agents other than ␤-lactams.…”

Section: Case Reviewmentioning

confidence: 99%

It's Not a Spider Bite, It's Community-Acquired Methicillin-Resistant Staphylococcus aureus

Dominguez

2004

The Journal of the American Board of Family Medicine

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“…In 1991, a study showed that Saudi and British strains differed in their sensitivity patterns to antibiotics [11]. In Riyadh, it was found that overcrowding of patients and inadequate infection control measures were the major risk factors for MRSA acquisition [12].…”

Section: Introductionmentioning

confidence: 99%

Phenotypic and molecular characterization of HA-MRSA in Taif hospitals, Saudi Arabia

Eed

Ghonaim

Hussein

et al. 2015

J Infect Dev Ctries

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Introduction: Methicillin-resistant S. aureus (MRSA) is one of the most important organisms causing hospital-acquired infections worldwide. Molecular analysis of MRSA strains from Taif, Saudi Arabia, had not been previously done. Phenotypic and molecular characteristics of MRSA isolated from Taif hospitals were investigated. Methodology: This study involved S. aureus strains isolated from different clinical samples from Taif hospitals. MRSA strains were identified and antimicrobial susceptibility profiles were determined. Multiplex polymerase chain reaction (PCR) was used to identify S. aureus-specific sequence, mecA genes, and type of staphylococcal cassette chromosome mec (SCCmec). MRSA strains were typed using coagulase gene polymorphism. Results: In total, 390 strains of S. aureus were isolated, and 58 MRSA strains -40 hospital-acquired MRSA (HA-MRSA) and 18 community-acquired MRSA (CA-MRSA) -were detected. HA-MRSA strains included three SCCmec types, while CA-MRSA strains included two SCCmec types. PCR amplification and restriction of the coagulase gene of the 58 MRSA isolates showed nine different patterns, while three strains were non-typable. HA-MRSA strains showed seven distinct restriction fragment length polymorphism (RFLP) patterns; the most frequent was pattern 2 (15 isolates), followed by patterns 1 and 4 (5 isolates each). CA-MRSA showed five RFLP patterns; the most frequent was pattern 3 (7 isolates) followed by pattern 8 (6 isolates). Conclusions: HA-MRSA strains were more common than CA-MRSA strains. SCCmec typing and coagulase gene polymorphism analysis may be useful methods for studying clonal relatedness of isolates and for discriminating between HA-MRSA and CA-MRSA.

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Emergence of methicillin-resistant Staphylococcus aureus as a community pathogen

Cited by 92 publications

References 11 publications

Methicillin-resistantStaphylococcus aureus(MRSA) in food production animals

Methicillin-resistantStaphylococcus aureus(MRSA) in food production animals

It's Not a Spider Bite, It's Community-Acquired Methicillin-Resistant Staphylococcus aureus

Phenotypic and molecular characterization of HA-MRSA in Taif hospitals, Saudi Arabia

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