Emergence of magnetic nanoparticles in photothermal and ferroptotic therapies

Abstract

With their distinctive physicochemical features, nanoparticles have gained recognition as effective multifunctional tools for biomedical applications, with designs and compositions tailored for specific uses. Notably, magnetic nanoparticles stand out as...

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives

“…It has many unique properties; NPs can penetrate membrane cells and migrate along neuronal synapses, blood vessels, and lymphatic vessels. 91 , 92 NPs can also selectively accumulate in different cellular structures, and the continued development of NPs synthesis technology is rapidly increasing the use of NPs in drug delivery, gene delivery, bioimaging, and tumor therapy. 93 , 94 Nanocarriers are NPs that encapsulate a drug or have a drug adsorbed on their surface, and the strong permeability and stability of NPs greatly increases drug efficacy.…”

“…Superparamagnetic iron oxide nanoparticles (SPIONs) are nanomaterials with superparamagnetic properties and core diameters ranging from 3 to 15 nm; SPIONs have excellent magnetic properties and stability and can be stabilized under physiological conditions. 91 , 142 , 143 Such NPs can be obtained by various preparation methods, including high‐temperature thermal decomposition of organic precursors and chemical synthesis. 144 , 145 , 146 Among them, high‐temperature pyrolysis of organic precursors is a commonly used preparation method to obtain SPIONs with uniform size and morphology; SPIONs can be used as contrast agents in magnetic resonance imaging to improve image resolution and contrast due to their small size and magnetic response.…”

Assessing the effect of iron oxide magnetic nanoflowers on blood components in a multi-scale approach in the context of thromboembolic disease

“…(14) As demonstrated in cancer therapy, multicore iron oxide nanoflowers (IONFs) are able to convert absorbed near-infrared (NIR) light into heat and thus act as heat mediators in targeted photothermal therapy. (15)(16)(17)(18) Besides traditional application in cancer treatment, IONPs have recently been used to treat local and systemic vascular diseases, such as atherosclerosis and thrombosis. (2) IONPs can be used in hyperthermal vascular treatment to improve blood flow.…”

Magnetic Iron Oxide Nanoparticles Coated by Coumarin-Bound Copolymer for Enhanced Magneto- and Photothermal Heating and Luminescent Thermometry

“…Indeed, they can efficiently convert magnetic energy into heat providing an important temperature rise of colloidal solutions containing nanoparticles at macroscopic level. Recent advancements have led to the development of highly efficient IONPs with various shapes, such as spherical, cubic or dendritic forms, achieving specific absorption rate (SAR) values of up to 1000 W g −1 [ 18 , 21 ]. More recently, IONPs have also been recognized as photothermal agents capable of providing an important temperature rise under irradiation in the near-infrared (NIR) window, making them competitive with conventional Au nano-objects [ 21 ].…”

“…Recent advancements have led to the development of highly efficient IONPs with various shapes, such as spherical, cubic or dendritic forms, achieving specific absorption rate (SAR) values of up to 1000 W g −1 [ 18 , 21 ]. More recently, IONPs have also been recognized as photothermal agents capable of providing an important temperature rise under irradiation in the near-infrared (NIR) window, making them competitive with conventional Au nano-objects [ 21 ]. Moreover, the possibility of employing them as dual magneto- and photothermal agents, therefore enhancing the heating ability by up to fivefold when compared to magnetic stimulation alone, reaching SAR values of up to 5000 W g −1 , has also been demonstrated [ 22 ].…”