Emergence of linezolid-resistant Staphylococcus aureus during treatment of pulmonary infection in a patient with cystic fibrosis

Emergence of Linezolid-Resistant Staphylococcus aureus after Prolonged Treatment of Cystic Fibrosis Patients in Cleveland, Ohio

“…Although LRSA isolates are emerging among patients undergo-ing prolonged periods of therapy (20,24,30,44,47), only three cases, one in Brazil and two in England, of infection due to resistant strains have been reported in CF patients. Both LRSA isolates identified in England were sequence type 36 (ST36), a widespread MRSA type observed in United Kingdom hospitals, whereas the type of the strain from Brazil is unknown (15,19).…”

Clonal Dissemination of Linezolid-Resistant Staphylococcus haemolyticus Exhibiting the G2576T Mutation in the 23S rRNA Gene in a Tertiary Care Hospital in Brazil

“…Linezolid inhibits protein synthesis by interacting with 23S rRNA in the 50S ribosomal subunit, and it should interfere with the binding of aminoacyl-tRNA to the ribosomal A site in the bacterial ribosome (5). Although linezolid resistance is mediated by the cfr-encoded product (8) or by mutations in ribosomal proteins (6,9), mutations in the central loop of domain V of 23S rRNA have been reported as the main mechanism associated with the expression of linezolid resistance among clinical staphylococcal strains (2,3,11).…”

Comparative Activities of TR-700 (Torezolid) against Staphylococcal Blood Isolates Collected in Spain

“…Newer antibiotics, such as linezolid, are alternatives in the treatment of severe infections caused by multidrug-resistant staphylococci. In the last few years, linezolid-resistant staphylococci, mainly in patients undergoing prolonged therapy, have been reported (4,5,13). The most common mechanism of linezolid resistance involves mutations in the 23S rRNA gene.…”