Emergence of linezolid resistant Staphylococcus aureus in Bastar tribal region, India

Khan, Mohammad Fareed

doi:10.5799/ahinjs.02.2012.03.0058

JMID

2012

DOI: 10.5799/ahinjs.02.2012.03.0058

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Emergence of linezolid resistant Staphylococcus aureus in Bastar tribal region, India

Mohammad Fareed Khan¹

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2014

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“…Linezolid inhibits bacterial protein syntheses by binding to the domain V region of 23S rRNA at an early step, and prevents the formation of the N-formylmethionyl-tRNA-mRNA-70S ribosomal tertiary complex. Mutations in the central loop of the domain V region are the most frequent causes of linezolid resistance ( Khan et al , 2012 ; Kloss et al , 1999 ).…”

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confidence: 99%

In vitro susceptibility to methicillin, vancomycin and linezolid of staphylococci isolated from bloodstream infections in eastern Turkey

Tekin¹,

Dal²,

Deveci³

et al. 2014

Braz. J. Microbiol.

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Staphylococcus species are one of the major causes of bacterial bloodstream infections. Multi-resistant staphylococci infections are major therapeutic problems. This study was aimed to detect methicillin, linezolid and vancomycin susceptibilities of Staphylococcus isolates. A total of 870 Staphylococcus strains isolated from blood cultures of hospitalized patients with BSI. Antimicrobial susceptibilities of methicillin, linezolid and vancomycin were detected according to the Clinical and Laboratory Standards Institute (CLSI). A total of 771 (88.6%) isolates were coagulase-negative staphylococci (CoNS). 700 (80.5%) isolates were methicillin-resistant (MR) and 170 (19.5%) were methicillin-susceptible (MS). All the MS isolates were also susceptible to linezolid. However 15 (1.7%) of MR strains were resistant to linezolid. The minimum inhibitory concentration range for the linezolid-resistant isolates by Etest was 6–32 μg/mL. The difference between linezolid susceptibilities for MS and MR staphylococci was not quite statistically significant (p = 0.052). There was no statistically significant difference between S. aureus and CoNS isolates for linezolid susceptibility. All of the isolates were susceptible to vancomycin. In conclusion, linezolid is currently an efficient option for the treatment of methicillin-resistant staphylococci infections.

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confidence: 99%

In vitro susceptibility to methicillin, vancomycin and linezolid of staphylococci isolated from bloodstream infections in eastern Turkey

Tekin¹,

Dal²,

Deveci³

et al. 2014

Braz. J. Microbiol.

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Emergence of linezolid resistant Staphylococcus aureus in Bastar tribal region, India

Cited by 1 publication

References 9 publications

In vitro susceptibility to methicillin, vancomycin and linezolid of staphylococci isolated from bloodstream infections in eastern Turkey

In vitro susceptibility to methicillin, vancomycin and linezolid of staphylococci isolated from bloodstream infections in eastern Turkey

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