Emergence of Lassa Fever Disease in Northern Togo: Report of Two Cases in Oti District in 2016

Patassi, Akouda; Landoh, Dadja Essoya; Tchalla, Agballa Mebiny-Essoh; Halatoko, Wemboo Afiwa; Assane, Hamadi; Saka, Bayaki; Naba, Mouchedou Abdoukarim; Yaya, Issifou; Edou, Kossi Atsissinta; Tamekloe, Tsidi Agbeko; Banla, Abiba Kere; Davi, Kokou Mawule; Manga, Magloire; Kassankogno, Y; Salmon‐Céron, Dominique

doi:10.1155/2017/8242313

Cited by 14 publications

(21 citation statements)

References 16 publications

(23 reference statements)

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“…reported that the outbreak of LHF was due to the poor living conditions of the community [23]. This result goes in the same direction as ours.…”

Section: Discussionsupporting

confidence: 87%

From Social Determinants of Health Actions to Fight against the Lassa Virus Hemorrhagic Fever Epidemic in Tchaourou Commune in Benin, 2018

Béhanzin¹,

Adoukonou²,

Houéto³

et al. 2019

OJEpi

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Background: Lassa Hemorrhagic Fever (LHF) is endemo-epidemic in West Africa with seasonal outbreaks raising a major public health issue. Nigeria borders Benin by the Tchaourou Commune. Since 2016, Tchaourou commune has been affected every year by this epidemic. Objective: To study how an action on the health social determinants can contribute to ending this epidemic in Tchaourou commune, Benin. Methods: This cross-sectional study was conducted in Tchaourou commune. All of the cases of LHF occurring in 2016-2018 were retrospectively tracked throughout the commune. The health workers and 172 participants of the general population of villages of the cases were enrolled. We used absolute frequency to describe the LHF cases because of their small number. The descriptive analyses were performed using EPI-INFO 7.1.14. Results: Overall, 27 cases of LHF occurred in Tchaourou. In these 27 cases, 12 were Laboratory-Confirmed. All 4 probable cases died while 42% and 18% died in the confirmed and suspected cases, respectively. Most (75%) of the cases were female. By direct observations, the commune had a weak health-promoting environment for fighting against LHF outbreak. According to the health care staff in the commune, the interventions were for controlling the outbreak and not the promoting interventions to preventing further outbreaks. Conclusion: To fight effectively against the Lassa fever, it is necessary to act on different social determinants of health with community participation, empowerment and health control. The fight against Lassa fever remains a major challenge facing developing countries like Benin.

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“…reported that the outbreak of LHF was due to the poor living conditions of the community [23]. This result goes in the same direction as ours.…”

Section: Discussionsupporting

confidence: 87%

From Social Determinants of Health Actions to Fight against the Lassa Virus Hemorrhagic Fever Epidemic in Tchaourou Commune in Benin, 2018

Béhanzin¹,

Adoukonou²,

Houéto³

et al. 2019

OJEpi

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“…Recently, however, two new LASV lineages emerged in Mali, Cô te d'Ivoire, Benin, and Togo (Manning et al, 2015;Whitmer et al, 2018). These lineages, termed LV and LVI, were linked to demonstrated humanto-human transmission and death in Germany and in Africa (Manning et al, 2015;McElroy et al, 2017;Patassi et al, 2017;Whitmer et al, 2018). A 2015-2016 surge in Nigeria was associated with 60% case fatality in clinic (Buba et al, 2018;Roberts, 2018;Tambo et al, 2018), with an unprecedented and more geographically disperse surge occurring in 2017-2018 (Roberts, 2018;Tambo et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization

Hastie

Cross

Harkins

et al. 2019

Cell

111

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“…First identified in 1969 in Nigeria,11 Lassa fever is now endemic in West Africa including Nigeria, Sierra Leone, Guinea, Liberia, Benin, Ghana and Mali and has spread to neighbouring countries (figure 1). 12–15 In some areas, 10%–16% of people admitted to hospitals every year have LASV 1. Cases have also been identified in Germany,13 15 16 the Netherlands,17 18 Sweden,19 the USA,20–22 the UK23 24 and Japan,25 largely imported after travel in West Africa 17 26–28.…”

Section: Introductionmentioning

confidence: 99%

Diagnostics for Lassa fever virus: a genetically diverse pathogen found in low-resource settings

Mazzola

Kelly-Cirino

2019

BMJ Glob Health

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Lassa fever virus (LASV) causes acute viral haemorrhagic fever with symptoms similar to those seen with Ebola virus infections. LASV is endemic to West Africa and is transmitted through contact with excretions of infected Mastomys natalensis rodents and other rodent species. Due to a high fatality rate, lack of treatment options and difficulties with prevention and control, LASV is one of the high-priority pathogens included in the WHO R&D Blueprint. The WHO LASV vaccine strategy relies on availability of effective diagnostic tests. Current diagnostics for LASV include in-house and commercial (primarily research-only) laboratory-based serological and nucleic acid amplification tests. There are two commercially available (for research use only) rapid diagnostic tests (RDTs), and a number of multiplex panels for differential detection of LASV infection from other endemic diseases with similar symptoms have been evaluated. However, a number of diagnostic gaps remain. Lineage detection is a challenge due to the genomic diversity of LASV, as pan-lineage sensitivity for both molecular and immunological detection is necessary for surveillance and outbreak response. While pan-lineage ELISA and RDTs are commercially available (for research use only), validation and external quality assessment (EQA) is needed to confirm detection sensitivity for all known or relevant strains. Variable sensitivity of LASV PCR tests also highlights the need for improved validation and EQA. Given that LASV outbreaks typically occur in low-resource settings, more options for point-of-care testing would be valuable. These requirements should be taken into account in target product profiles for improved LASV diagnostics.

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Emergence of Lassa Fever Disease in Northern Togo: Report of Two Cases in Oti District in 2016

Cited by 14 publications

References 16 publications

From Social Determinants of Health Actions to Fight against the Lassa Virus Hemorrhagic Fever Epidemic in Tchaourou Commune in Benin, 2018

From Social Determinants of Health Actions to Fight against the Lassa Virus Hemorrhagic Fever Epidemic in Tchaourou Commune in Benin, 2018

Convergent Structures Illuminate Features for Germline Antibody Binding and Pan-Lassa Virus Neutralization

Diagnostics for Lassa fever virus: a genetically diverse pathogen found in low-resource settings

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