Emergence of Klebsiella pneumoniae co-producing OXA-48, CTX-M-15, and ArmA in Greece

Galani, Irene; Anagnostoulis, Georgios; Chatzikonstantinou, Marianthi; Petrikkos, George; Souli, María

doi:10.1016/j.cmi.2016.08.002

Cited by 15 publications

(6 citation statements)

References 6 publications

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“…Since then, sporadic cases have been observed in hospitals in Athens (Attica), Patras (Peloponnese, western Greece) and Larissa (Thessaly, central Greece), all belonging to multilocus sequence type (ST) 11 type [4][5][6]. The first OXA-48-like carbapenemase outbreak was detected in 2012 [7] and apart from single cases [8,9], no major epidemics have been recorded in Greece.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and resistance phenotypes of carbapenemase-producing Klebsiella pneumoniae in Greece, 2014 to 2016

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Epidemiology and resistance phenotypes of carbapenemase-producing Klebsiella pneumoniae in Greece, 2014 to 2016

et al. 2018

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“…Due to the good performance of carbapenems in controlling the MDR bacteria, spreading resistance to these antibiotics can increase the prevalence of XDR K. pneumoniae isolates, which increases the cost and duration of treatment. Also, the emergence of XDR K. pneumoniae isolates has been observed in different parts of the world [ 31 , 32 ]. Nevertheless, carbapenems have been significantly effective on K. pneumoniae isolates in various regions of the world as reported in the studies by Zhang et al.…”

Section: Discussionmentioning

confidence: 99%

The complex genetic region conferring transferable antibiotic resistance in multidrug-resistant and extremely drug-resistant Klebsiella pneumoniae clinical isolates

Moghadam

Shariati

Mirkalantari

et al. 2020

New Microbes and New Infections

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Antibiotic resistance due to transferable resistance genes is one of the most important concerns in Klebsiella pneumoniae isolated from nosocomial infections. Eighty-eight K. pneumoniae isolates were confirmed through biochemical methods. In addition, antimicrobial susceptibility testing was performed using a disc-diffusion method. Extended-spectrum β-lactamase production among the isolates was screened using a double-disc synergism test, and the resistance genes were identified using PCR. The eight loci for multiple-locus variable number tandem repeat analysis (MLVA) genotyping were selected along with the primers. According to our findings, neomycin (5; 5.6%) and carbapenems (10; 11.3%) showed the most remarkable inhibitory effect but co-trimoxazole (46; 52.2%) was the least effective antibiotic against K. pneumoniae isolates. bla CTX-M-1 , qnrA , qnrB , qnrS , intI , intII , aac3 and aac6 were detected in 30 (34%), 5 (5.6%), 29 (32.9%), 23 (26.1%), 88 (100%), 72 (81.8%), 26 (29.5%) and 28 (31.8%) of the 88 isolates, respectively. But none of the K. pneumoniae isolates expressed the intIII gene. Using MLVA, 23 MLVA types and eight clusters were identified. Extended-spectrum β-lactamase-producing K. pneumoniae isolates were classified into two clonal complexes. Effective strategies for infection control should be applied to monitor and control the spread of multidrug-resistant isolates by the resistance genes located on the mobile genetic elements.

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“…Finally, plasmid-mediated 16S rRNA methylase aminoglycoside resistance determinants armA, rmtB, rmtC, and rmtF were also combined with OXA-48-like producers. They were observed in Australia, Greece, India, Morocco, North America, and Thailand [60,76,80,98,103,104]. In addition, aac(3)-II determinant were recovered in K. pneumoniae in Morocco [61].…”

Section: Additional Co-located Resistance Genesmentioning

confidence: 96%

OXA-48-like carbapenemases producing Enterobacteriaceae in different niches

Mairi

Pantel

Sotto

et al. 2017

Eur J Clin Microbiol Infect Dis

134

115

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The emergence of carbapenem-resistant enterobacterial species poses a serious threat to public health worldwide. OXA-48-type carbapenem-hydrolyzing class D β-lactamases are widely distributed among Enterobacteriaceae, with significant geographical differences. To date, 11 OXA-48-like variants have been identified, with classical OXA-48 being the most widespread. These enzymes show high-level hydrolytic activity against penicillins and low-level hydrolysis towards carbapenems. Since the first description of the OXA-48 carbapenemase in Turkey, bacterial strains producing the enzyme have been extensively reported in nosocomial and community outbreaks in many parts of the word, particularly in the Mediterranean area and European countries. The rapid spread of Enterobacteriaceae producing OXA-48-like enzymes in different ecosystems has become a serious issue recently. The number of reservoirs for such organisms is increasing, not only in hospitals, but also in the community, among animals (e.g., livestock, companion animals, and wildlife) and in the environment. This review aims to summarize the main characteristics of the OXA-48-type carbapenemases, covering genetic and enzymatic traits, their epidemiology, clonality and associated genes, correlation with extended-spectrum β-lactamases (ESBLs) or plasmidic AmpC (pAmpC) in different bacterial species worldwide.

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Emergence of Klebsiella pneumoniae co-producing OXA-48, CTX-M-15, and ArmA in Greece

Cited by 15 publications

References 6 publications

Epidemiology and resistance phenotypes of carbapenemase-producing Klebsiella pneumoniae in Greece, 2014 to 2016

Epidemiology and resistance phenotypes of carbapenemase-producing Klebsiella pneumoniae in Greece, 2014 to 2016

The complex genetic region conferring transferable antibiotic resistance in multidrug-resistant and extremely drug-resistant Klebsiella pneumoniae clinical isolates

OXA-48-like carbapenemases producing Enterobacteriaceae in different niches

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