2009
DOI: 10.1093/jac/dkp188
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Emergence of high-level azithromycin resistance in Neisseria gonorrhoeae in England and Wales

Abstract: High-level azithromycin resistance has emerged in England and Wales. Contact tracing and typing data suggest this may have originated from Scotland. Surveillance of azithromycin resistance will be key in controlling its further dissemination.

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Cited by 111 publications
(64 citation statements)
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“…Emerging resistance to extended-spectrum cephalosporins (19,29,30), as well as resistance to fluoroquinolone (15,41) and macrolide (8,10,13,23) antibiotics, among gonococcal isolates is an ongoing challenge for the treatment and control of gonorrhea infections. In this study, we have provided insight into the antimicrobial profiles of N. gonorrhoeae isolates collected over a large geographic area using past and present antimicrobial agents recommended for gonococcal treatment (5,6).…”
Section: Discussionmentioning
confidence: 99%
“…Emerging resistance to extended-spectrum cephalosporins (19,29,30), as well as resistance to fluoroquinolone (15,41) and macrolide (8,10,13,23) antibiotics, among gonococcal isolates is an ongoing challenge for the treatment and control of gonorrhea infections. In this study, we have provided insight into the antimicrobial profiles of N. gonorrhoeae isolates collected over a large geographic area using past and present antimicrobial agents recommended for gonococcal treatment (5,6).…”
Section: Discussionmentioning
confidence: 99%
“…Case reports of AZM-resistant N. gonorrhoeae have been described in many countries, including Canada and the United States (10)(11)(12)(13)(14)(15)(16)(17)(18), but only rarely has AZM-resistant N. gonorrhoeae been reported to be associated with concurrent reduced susceptibility to 3GC (16,17). In Canada, AZM-resistant N. gonorrhoeae was first identified in 1997, and the first AZM-resistant isolates were identified in Ontario in 1998 (10).…”
mentioning
confidence: 99%
“…A higher dose of 2 g of new formulations of azithromycin with a lower incidence of gastrointestinal intolerance may be more effective (9), but recent descriptions of gonococcal strains showing azithromycin resistance or high-level azithromycin resistance (AzHLR; MIC of azithromycin, Ͼ256 mg/liter) would make that treatment untenable if strains of this type were to emerge elsewhere and spread (1,2,6).…”
mentioning
confidence: 99%