Emergence of equine‐like G3 and porcine‐like G9 rotavirus strains in Sarawak, Malaysia: 2019−2021

Tahar, Ahmad Syatir; Ong, Eng Joe; Rahardja, Andy; Mamora, Dewi; Lim, Khwang Thong; Ahmed, Kamruddin; Kulai, Dorothy; Tan, Cheng Siang

doi:10.1002/jmv.28987

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…In recent years, novel human rotaviruses representing potential reassortment events between human and equine rotaviruses have been detected and spread globally. Specifically, since 2013, a novel DS-1-like intergenogroup reassortant with a VP7 of equine origin and designated as "equine-like G3" has emerged in the human population and rapidly spread to many countries across five continents, in some instances with endemic circulation [15,55,57,58,[171][172][173][174][175][176][177]. The first report dates to April 2013, when two novel G3P [4] rotavirus strains were detected in children suffering from acute gastroenteritis in Sendai, Japan [15].…”

Section: Viral Evolution and Emergence Of Rotaviruses That Cross Spec...mentioning

confidence: 99%

Equine Rotavirus A under the One Health Lens: Potential Impacts on Public Health

Carossino,

Vissani,

Barrandeguy

et al. 2024

Viruses

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Group A rotaviruses are a well-known cause of viral gastroenteritis in infants and children, as well as in many mammalian species and birds, affecting them at a young age. This group of viruses has a double-stranded, segmented RNA genome with high genetic diversity linked to point mutations, recombination, and, importantly, reassortment. While initial molecular investigations undertaken in the 1900s suggested host range restriction among group A rotaviruses based on the fact that different gene segments were distributed among different animal species, recent molecular surveillance and genome constellation genotyping studies conducted by the Rotavirus Classification Working Group (RCWG) have shown that animal rotaviruses serve as a source of diversification of human rotavirus A, highlighting their zoonotic potential. Rotaviruses occurring in various animal species have been linked with contributing genetic material to human rotaviruses, including horses, with the most recent identification of equine-like G3 rotavirus A infecting children. The goal of this article is to review relevant information related to rotavirus structure/genomic organization, epidemiology (with a focus on human and equine rotavirus A), evolution, inter-species transmission, and the potential zoonotic role of equine and other animal rotaviruses. Diagnostics, surveillance and the current status of human and livestock vaccines against RVA are also reviewed.

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Section: Viral Evolution and Emergence Of Rotaviruses That Cross Spec...mentioning

confidence: 99%

Equine Rotavirus A under the One Health Lens: Potential Impacts on Public Health

Carossino,

Vissani,

Barrandeguy

et al. 2024

Viruses

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Emergence and dissemination of equine-like G3P[8] rotavirus A in Brazil between 2015 and 2021

Gutierrez,

Arantes,

Bello

et al. 2024

Microbiol Spectr

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Rotavirus A (RVA) is a major cause of acute gastroenteritis globally that is classically genotyped by its two immunodominant outer capsid proteins, VP7 (G-) and VP4 (P-). Recent evidence suggests that the reassortant equine-like G3P[8] strain played a substantial role in RVA transmission in Brazil since 2015. To understand its global emergence and dissemination in Brazilian territory, stool samples collected from 11 Brazilian states ( n = 919) were genotyped by RT-qPCR and proceeded to sequence the VP7 gene ( n = 102, 79 being newly generated) of the G3P[8] samples with pronounced viral loads. Our phylogenetic genotyping showed that G3P[8] became the dominant strain in Brazil between 2017 and 2020, with equine-like variants representing 75%–100% of VP7 samples in this period. A Bayesian discrete phylogeographic analysis strongly suggests that the equine-like G3P[8] strain originated in Asia during the early 2010s and subsequently spread to Europe, the Caribbean, and South America. Multiple introductions were detected in Brazil between 2014 and 2017, resulting in five national clusters. The reconstruction of the effective population size of the largest Brazilian cluster showed an expansion until 2017, followed by a plateau phase until 2019 and subsequent contraction. Our study also supports that most mutations fixed during equine-like G3P[8] evolution were synonymous, suggesting that adaptive evolution was not an important driving force during viral dissemination in humans, potentially increasing its susceptibility to acquired immunity. This research emphasizes the need for comprehensive rotavirus genomic surveillance that allows close monitoring of its ever-shifting composition and informs more effective public health policies. IMPORTANCE Our original article demonstrated the origin and spread in a short time of equine-like G3P[8] in Brazil and the world. Due to its segmented genome, it allows numerous mechanisms including genetic drift and reassortment contribute substantially to the genetic diversity of rotavirus. Although the effectiveness and increasing implementation of vaccination have not been questioned, a matter of concern is its impact on the emergence of escape mutants or even the spread of unusual strains of zoonotic transmission that could drive epidemic patterns worldwide. This research emphasizes the need for comprehensive rotavirus genomic surveillance, which could facilitate the formulation of public policies aimed at preventing and mitigating its transmission.

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Emergence of equine‐like G3 and porcine‐like G9 rotavirus strains in Sarawak, Malaysia: 2019−2021

Cited by 2 publications

References 44 publications

Equine Rotavirus A under the One Health Lens: Potential Impacts on Public Health

Equine Rotavirus A under the One Health Lens: Potential Impacts on Public Health

Emergence and dissemination of equine-like G3P[8] rotavirus A in Brazil between 2015 and 2021

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