Emergence of Cunninghamella As a Pathogenic Invasive Mold Infection in Allogeneic Transplant Recipients

Strasfeld, Lynne; Espinosa-Aguilar, Luis; Gajewski, James; Stenzel, Peter; Pimentel, Agustin; Mater, Elana; Maziarz, Richard T.

doi:10.1016/j.clml.2013.05.002

Cited by 9 publications

(7 citation statements)

References 44 publications

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“…Among Mucorales, Cunninghamella spp. appears as a particularly aggressive breakthrough genus in haematological stem cell transplantation recipients associated with an overall mortality rate of 80%, which is higher than other Mucorales (Strasfeld et al ., ).…”

Section: Constantly Increasing Incidence Of ‘Old Emerging’ Fungimentioning

confidence: 97%

“…Mucorales illustrate perfectly the notion of hostpathogen adaptation: they emerged a few decades ago in haematological populations and their growing evolution follows that of the patients at risk. Among Mucorales, epidemiological microphenomena are noteworthy as illustrated by breakthrough of rare species, as for example the genera Apophysomyces, that have emerged in unusual scenarios, such as those observed in natural disasters or as primary cutaneous infections reported in China (Li et al, 2013;Strasfeld et al, 2013;Tribble et al, 2013;Chander et al, 2014).…”

Section: Mucorales: An Expanding Aggressive Bugmentioning

confidence: 99%

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Emerging infections due to filamentous fungi in humans and animals: only the tip of the iceberg?

Debourgogne

Dorin

Machouart

2016

Environ Microbiol Rep

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Over the last few decades, the number of patients susceptible to invasive filamentous fungal infections has steadily increased, especially in populations suffering from hematological diseases. The pathogens responsible for such mycoses are now quite well characterized, such as Aspergillus spp. - the most commonly isolated mold -, Mucorales, Fusarium spp., Scedosporium spp. or melanized fungi. An increase in the incidence of this category of 'emerging' fungi has been recently highlighted, evoking a shift in fungal ecology. Starting from these medical findings, taking a step back and adopt a wider perspective offers possible explanations of this phenomenon on an even larger scale than previously reported. In this review, we illustrate the link between emerging fungi in medicine and changes in ecology or human behaviours, and we encourage integrative approaches to apprehend the adverse effects of progress and develop preventive measures in vast domains, such as agriculture or medicine.

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Section: Constantly Increasing Incidence Of ‘Old Emerging’ Fungimentioning

confidence: 97%

Section: Mucorales: An Expanding Aggressive Bugmentioning

confidence: 99%

Emerging infections due to filamentous fungi in humans and animals: only the tip of the iceberg?

Debourgogne

Dorin

Machouart

2016

Environ Microbiol Rep

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“…Specific Mucorales strains such as Cunninghamella may be becoming more frequent [17] but reported cases of mucormycosis generally remain rare in these patients [18]. However, Pagano considered that the reported rate of infection might be artificially low due to the difficulties in diagnosing mucormycosis.…”

Section: Mucormycosismentioning

confidence: 98%

Celebrating 40 Years of Progress in Bone Marrow Transplantation: A Report from the 40th Annual Meeting of the European Society for Blood and Marrow Transplantation

Pagano

Lyon²

2014

Future Microbiol.

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The European Society for Blood and Marrow Transplantation was established in 1974 to enable scientists and physicians involved in clinical bone marrow transplantation to share their experience and develop cooperative studies. The organization celebrated its 40th anniversary with a meeting that considered hematopoietic stem cell transplantation not as a standalone procedure, but as part of a complex therapeutic program managed by a multidisciplinary professional team. The role of antifungal prophylaxis, emerging resistance in Aspergillus, the management of mucormycosis and new guidelines on antifungal therapy were among the topics discussed by the physicians, nurses, allied health professionals and scientists attending the 40th Annual Meeting of the European Society for Blood and Marrow Transplantation.

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“…Among Mucorales, Rhizopus spp. are the most commonly identified in human infection, along with Mucor , Rhizomucor , Lichtheimia , and Cunninghamella spp., which are particularly aggressive in HSCT recipients, with a mortality rate of 80% …”

Section: Emerging Threats Of Drug‐resistant Filamentous Fungal Pathogensmentioning

confidence: 99%

“…are the most commonly identified in human infection, along with Mucor, Rhizomucor, Lichtheimia, and Cunninghamella spp., which are particularly aggressive in HSCT recipients, with a mortality rate of 80%. 155 Treatment of infection is often challenging due to delayed diagnosis, acute disease progression, and intrinsic resistance to many currently available antifungal agents. 156 Treatment strategies often involve surgery at the pathogen-infected body sites, as well as antifungal therapies.…”

Section: Emerging Threats Of Drug-resistant Filamentous Fungal Pathogensmentioning

confidence: 99%

New pathogens, new tricks: emerging, drug‐resistant fungal pathogens and future prospects for antifungal therapeutics

Geddes‐McAlister

Shapiro

2018

Annals of the New York Academy of Sciences

131

103

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Fungal pathogens are a growing threat to public health. As human immunodeficiency becomes increasingly common, fungal infections are becoming more prevalent. The use of antifungal agents for prophylaxis and treatment of fungal infections has favored the emergence of previously rare or unidentified species of drug-resistant fungal pathogens, including several Candida and Cryptococcus species, as well as mold pathogens. As these new and increasingly drug-resistant fungal pathogens continue to emerge, novel strategies for rapid identification and treatment are necessary to combat these life-threatening infections.

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Emergence of Cunninghamella As a Pathogenic Invasive Mold Infection in Allogeneic Transplant Recipients

Cited by 9 publications

References 44 publications

Emerging infections due to filamentous fungi in humans and animals: only the tip of the iceberg?

Emerging infections due to filamentous fungi in humans and animals: only the tip of the iceberg?

Celebrating 40 Years of Progress in Bone Marrow Transplantation: A Report from the 40th Annual Meeting of the European Society for Blood and Marrow Transplantation

New pathogens, new tricks: emerging, drug‐resistant fungal pathogens and future prospects for antifungal therapeutics

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