Emergence of Candidemia and Evaluation of HiChrome Candida Differential Agar and VITEK2 YST® Platform for Differentiation of Candida Bloodstream Isolates in Sri Lanka

Kothalawala, Mahen; Jayaweera, Jayaweera Arachchige Asela Sampath; Arunan, Sinnapoo; Jayathilake, Anuradha

doi:10.37247/pamic.1.2020.19

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar trends of Candida non-albicans have been isolated and observed in various studies, 1,5,7,8,[16][17][18][19] while other studies show a predominance of Candida glabrata and Candida albicans. [20][21][22][23] Phospholipase activity and biofilm formation have been found to be important virulence factors in C. tropicalis contributing to pathogenicity in candidemia patients. 19,24 Regarding antifungal susceptibility testing, most of the isolates were found to be sensitive to all the four drugs tested including Amphotericin B (72.7%), Fluconazole (81.8%), Itraconazole (100%) and Voriconazole (100%) similar to other studies.…”

Section: % Of the Isolatedmentioning

confidence: 99%

A Study on Prevalence and Characterization of Candida Species in Immunocompromised Patients

Nandini¹,

Manonmoney²,

Lavanya³

et al. 2021

J. Pure Appl. Microbiol.

View full text Add to dashboard Cite

Candida spp. is one among the major causes of nosocomial infection, with candidemia gaining increasing prevalence worldwide in parallel with mortality rates ranging from 10-49%. Epidemiology and predisposing factors of candidemia have changed since the number of patients receiving transplants and immunosuppressive therapy, the use of broadspectrum antimicrobials, and the number of AIDS patients have increased. Candidemia is more common among patients with subcutaneous and cutaneous candida infections, through percutaneous inoculation. Major predisposing factors for invasive candidiasis includes neutropenia, haematological malignancies, bone marrow transplantation, total parenteral nutrition, chemotherapy, invasive procedures, and immune-suppressive agents. This study analyses the risk factors of immunocompromised patients with candidemia and antibiogram of Candida spp. isolated from ICU patients. To evaluate the prevalence, distribution and antibiogram of Candida spp., associated risk factors, and outcome in candidemia patients. Blood samples received from patients with clinically suspected fungal infections were subjected to gram staining, culture, sugar assimilation & fermentation, Candida Chrome agar (CCA) & Corn meal agar for identification and speciation. Antifungal susceptibility tests were performed by disk-diffusion tests. Among a total of 337 samples received, 22 (6.5%) samples were positive for candida infections, of which Candida tropicalis 9 (41%) was the predominant isolate followed by C. albicans 5 (23%), Candida glabrata 4 (18%), Candida parapsilosis 2 (9%) and Candida krusei 2 (9%). Male patients had a higher prevalence of candidemia 15 (68.2%). Among the age group of 51-70 years, uncontrolled DM(Diabetes mellitus) and CKD (chronic kidney disease) were found to be the predominant co-morbidities with candidemia.

show abstract