Emergence of ampicillin-resistant Enterococcus faecium in Danish hospitals

Lester, Camilla H.; Sandvang, Dorthe; Olsen, Stefan S.; Schønheyder, Henrik Carl; Jarløv, Jens Otto; Bangsborg, Jette; Hansen, Dennis Schrøder; Jensen, Thøger Gorm; Frimodt‐Møller, Niels; Hammerum, Anette M.

doi:10.1093/jac/dkn360

Cited by 66 publications

(44 citation statements)

References 9 publications

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“…In agreement with other studies, the CC17 meroclone consisted of a high diversity of STs (ST16, ST18, ST78, ST80, ST125, ST132, ST280, ST368, ST369, ST390, ST393, ST430, and ST431), particularly enriched by ST18 (7,18,29,36,37) (Table 1). All CC17 isolates were resistant to ampicillin and erythromycin, and most of them were associated with resistance to glycopeptides (75%) and ciprofloxacin (71%) and a high level of resistance to kanamycin (58%) and streptomycin (50%).…”

supporting

confidence: 92%

“…CC17 is the only recognized E. faecium HiRCC, nowadays globally disseminated, which has been sporadically isolated from nonhospitalized humans (3,(8)(9)(10). Different studies have analyzed the population structure of local enterococci, but they are focused mainly on clinical strains with a specific phenotype, such as vancomycin resistance, generally isolated in a short temporal frame (2,7,16,18,27,29,36).…”

mentioning

confidence: 99%

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Dispersion of Multidrug-Resistant Enterococcus faecium Isolates Belonging to Major Clonal Complexes in Different Portuguese Settings

Freitas

Novais

Ruíz-Garbajosa

et al. 2009

Appl Environ Microbiol

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The population structure of 56 Enterococcus faecium isolates selected from a collection of enterococci from humans, animals, and the environment in Portugal (1997 to 2007) was analyzed by multilocus sequence typing. We identified 41 sequence types clustering into CC17, CC5, CC9, CC22 and CC94, all clonal lineages comprising isolates from different hosts. Our findings highlight the role of community-associated hosts as reservoirs of enterococci able to cause human infections.

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supporting

confidence: 92%

mentioning

confidence: 99%

Dispersion of Multidrug-Resistant Enterococcus faecium Isolates Belonging to Major Clonal Complexes in Different Portuguese Settings

Freitas

Novais

Ruíz-Garbajosa

et al. 2009

Appl Environ Microbiol

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“…Certain European countries (Netherlands, Denmark, Spain) showed a wide prevalence of hospital-associated clonal types of E. faecium but vancomycin resistance rates are still low (Oteo et al, 2007;Lester et al, 2008;Top et al, 2008b;Valdezate et al, 2009;Lester et al, 2009). In other countries rates of VRE remain at a comparably high rate such as Ireland and Portugal 5 (Novais et al, 2008;Morris-Downes et al, 2010).…”

Section: Europementioning

confidence: 99%

Current Trends of Emergence and Spread of Vancomycin-Resistant Enterococci

Werner¹

2012

Antibiotic Resistant Bacteria - A Continuous Challenge in the New Millennium

184

229

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“…Research Article ampicillin (ampicillin-resistant enterococci [ARE]), highlevel aminoglycoside and glycopeptides (vancomycinresistant enterococci [VRE]) (Billström et al, 2008, Lester et al, 2008Sava et al, 2010;Toledo-Arana et al, 2001). Enterococcal infections are mostly caused by Enterococcus faecalis and E. faecium.…”

Section: Araştırma Makalesimentioning

confidence: 99%

Köpek ve Kedi Rektal Svablarından İzole Edilen Ampisilin-Dirençli Enterokokların İncelenmesi

Çelik¹,

Bağcıgil²,

Koenhemsi³

et al. 2016

İstanbul Üniversitesi Veteriner Fakültesi Dergisi

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Enterococci species, which are normal inhabitants of the gut flora of healthy animals and human, began to be recognized as an important pathogen in both human and veterinary medicine due to the acquired resistance profiles. The aim of the study is to examine the diversity of ampicillin resistance enterococci (ARE) species in cats and dogs, their antimicrobial susceptibility profiles and to determine some of the virulence related genes; ace, gelE, efaA, agg and esp. For this purpose, rectal swabs from companion animals were collected and processed for ampicillin resistant enterococci isolation. One hundred fifty seven swab samples (86 canine and 71 feline) were examined. ARE were isolated from 18 canine and 18 feline samples. All isolates identified as E. faecium by PCR. Antimicrobial susceptibilities of the isolates were determined by disk diffusion method. The isolates were resistant to ampicillin, penicillin, tetracycline (100%), followed by rifampicin and erythromycin (97%), streptomycin (92%), gentamicin (81%), ciprofloxacin (61%), nitrofurantoin (19%). Only two of E. faecium isolates were resistant to vancomycin and one to chloramphenicol. Multidrug resistance (resistance ≥4 antimicrobials) observed in all isolates. Virulence genes ace, agg and esp were not detected in any of the tested isolates. The efaA and gelE genes detection rates were, 13.8% and 11.1% respectively. The ARE isolation rate among pet animals was 22.9%. Screening of antimicrobial resistant enterococci among companion animals would be useful to detect any emerging antimicrobial resistance problem related with public health. Özet Köpek ve Kedi Rektal Svablarından İzole Edilen Ampisilin-Dirençli Enterokokların (ARE) İncelenmesiSağlıklı hayvanlar ve insanların barsak florasının bir parçası olan Enterekok türleri, kazanılmış direnç profilleri nedeniyle hem insan hem de hayvan hekimliğinde önemli birer patojen olarak tanınmaya başlanmıştır. Bu çalışmada, kedi ve köpeklerde ampisiline dirençli enterokok (ARE) türlerinin dağılımını, antimikrobiyal duyarlılık profillerini ve bu izolatların virülans ile ilişkili ace, gelE, efaA, agg ve esp genleri incelendi. Bu amaçla evcil hayvanlardan (86 köpek, 71 kedi) toplanan yüz elli yedi svap örneği ampisilin dirençli enterokok izolasyonu yönünden incelendi. ARE 18 kedi ve 18 köpek örneğinden izole edildi. İzolatların antimikrobiyal duyarlılıkları disk difüzyon metodu ile belirlendi. Bütün izolatlar PCR ile E.faecium olarak saptandı. İzolatlar ampisilin, penisilin ve tetrasiklin (%100), rifampisin ve eritromisin (%97), streptomisin (%92), gentamisin (%81), siprofloksasin (%61) ve nitrofurantoin'e (%19) dirençliydi. Sadece iki izolat vankomisine, bir izolat kloramfenikole dirençliydi. Bütün izolatlarda çoklu-antibiyotik direnci (direnç ≥4 antimikrobiyal) saptandı. Virülens genleri ace, agg ve esp test edilen hiçbir izolatta saptanmadı. efaA ve gelE genlerinin saptanma oranları sırasıyla %13,8 ve %11,1 di. Pet hayvanlarında ARE izolasyon oranı %22,9 olarak saptandı. Evcil hayvanlar arasında antimikrob...

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Emergence of ampicillin-resistant Enterococcus faecium in Danish hospitals

Abstract: Ampicillin-resistant E. faecium isolates have increased in frequency in Denmark during 2002-2006. Most of the ampicillin-resistant E. faecium isolates belong to complex CC17.

Cited by 66 publications

References 9 publications

Dispersion of Multidrug-Resistant Enterococcus faecium Isolates Belonging to Major Clonal Complexes in Different Portuguese Settings

Dispersion of Multidrug-Resistant Enterococcus faecium Isolates Belonging to Major Clonal Complexes in Different Portuguese Settings

Current Trends of Emergence and Spread of Vancomycin-Resistant Enterococci

Köpek ve Kedi Rektal Svablarından İzole Edilen Ampisilin-Dirençli Enterokokların İncelenmesi

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