Emergence of activation or repression in transcriptional control under a fixed molecular context
Rosa Martinez-Corral,
Dhana Friedrich,
Robert Frömel
et al.
Abstract:For decades, studies have noted that transcription factors (TFs) can behave as either activators or repressors of different target genes. More recently, evidence suggests TFs can act on transcription simultaneously in positive and negative ways. Here we use biophysical models of gene regulation to define, conceptualize and explore these two aspects of TF action: “duality”, where TFs can be overall both activators and repressors at the level of the transcriptional response, and “coherent and incoherent” modes o… Show more
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