Emergence of a new lumpy skin disease virus variant in Kurgan Oblast, Russia, in 2018

Кононов, А. В.; Prutnikov, Pavel; Bjadovskaya, Olga; Kononova, Svetlana; Vladimir, Rusaleev; Pestova, Yana; Sprygin, Alexander

doi:10.1007/s00705-020-04607-5

Cited by 22 publications

(27 citation statements)

References 26 publications

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“…The recent Russian isolates Omsk/2018 (both), Samara1462/2018, Sverdlovsk/2018, and Chelyabinsk/2018 were clustered in the vaccine group with 100% similarity. Samara1461/2018 was identical to Kurgan/2018 (isolate not sequenced herein) [36] and the KSGP vaccine.…”

Section: Amino Acid Phylogenetic Analysismentioning

confidence: 77%

“…Both loci (RPO30 and GCPR) of the Russian field isolate Samara/1462/2018 were identical to the vaccine isolate in the commercial product Lumpyvax (Figs 1 and 2). Sequence analysis of the RPO30 loci indicated that the Russian field isolate Samara/1461/2018 shared 99.5% and 99.1% similarity with the Russian field isolate Dagestan/2015 (isolate not sequenced herein) [18] and KSGP-like Kurgan/2018 isolate (isolate not sequenced herein) [36], respectively. The GCPR locus of the Samara/1461/2018 isolate contained the CTCAGTACAATT insertion site and showed 98.4% and 100% similarity with Dagestan/2015 (isolate not sequenced herein) and KSGP-like Kurgan/2018 (isolate not sequenced herein), isolates respectively.…”

Section: Fig 2 Unrooted Phylogenetic Tree Showing the Relationships mentioning

confidence: 99%

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Evidence of recombination of vaccine strains of lumpy skin disease virus with field strains, causing disease

et al. 2020

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Vaccination against lumpy skin disease (LSD) is crucial for maintaining the health of animals and the economic sustainability of farming. Either homologous vaccines consisting of live attenuated LSD virus (LSDV) or heterologous vaccines consisting of live attenuated sheeppox or goatpox virus (SPPV/GPPV) can be used for control of LSDV. Although SPPV/ GTPV-based vaccines exhibit slightly lower efficacy than live attenuated LSDV vaccines, they do not cause vaccine-induced viremia, fever, and clinical symptoms of the disease following vaccination, caused by the replication capacity of live attenuated LSDVs. Recombination of capripoxviruses in the field was a long-standing hypothesis until a naturally occurring recombinant LSDV vaccine isolate was detected in Russia, where the sheeppox vaccine alone is used. This occurred after the initiation of vaccination campaigns using LSDV vaccines in the neighboring countries in 2017, when the first cases of presumed vaccine-like isolate circulation were documented with concurrent detection of a recombinant vaccine isolate in the field. The follow-up findings presented herein show that during the period from 2015 to 2018, the molecular epidemiology of LSDV in Russia split into two independent waves. The 2015-2016 epidemic was attributable to the field isolate. Whereas the 2017 epidemic and, in particular, the 2018 epidemic represented novel disease importations that were not genetically linked to the 2015-2016 field-type incursions. This demonstrated a new emergence rather than the continuation of the field-type epidemic. Since recombinant vaccine-like LSDV isolates appear to have entrenched across the country's border, the policy of using certain live vaccines requires revision in the context of the biosafety threat it presents.

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Section: Amino Acid Phylogenetic Analysismentioning

confidence: 77%

Section: Fig 2 Unrooted Phylogenetic Tree Showing the Relationships mentioning

confidence: 99%

Evidence of recombination of vaccine strains of lumpy skin disease virus with field strains, causing disease

et al. 2020

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“…The existence of vaccine-like field isolates with mixed characteristics between common field viruses and the LSDV Neethling vaccine has been reported in Russia [24]. A more recent report described a field LSDV isolate in Kurgan, Russia, exhibiting similarities to LSDV KSGP 0240 and LSDV NI2490 based on the analysis of GPCR and RPO30 gene fragments [26]. Although the complete RPO30 and GPCR sequences were not available for a full comparison, we noticed a nucleotide difference between the partial RPO30 sequence of the Kurgan isolate and those of this study.…”

Section: Discussionmentioning

confidence: 99%

“…The authors attributed these variants' emergence to recombination events between the Neethling vaccine strain and field isolates [23]. This has prompted researchers [26] to question the relevance of current strategies to differentiate LSDV vaccine strains from viral field strains. Similarly, the LSDV strains involved in the outbreaks in China present the GPCR profile of LSDV vaccines with the 27-nucleotide insertion in their EEV glycoprotein gene.…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of lumpy skin disease virus (LSDV) emerged in Bangladesh reveals unique genetic features compared to contemporary field strains

et al. 2021

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Background Lumpy skin disease (LSD) is a contagious viral disease of cattle caused by lumpy skin disease virus (LSDV). LSD has recently spread in Asia following outbreaks in the Middle East and Europe. The disease emerged in Bangladesh in July 2019 in the Chattogram district, then rapidly spread throughout the entire country. We investigated six LSD outbreaks in Bangladesh to record the clinical signs and collect samples for diagnostic confirmation. Furthermore, we performed the molecular characterization of Bangladesh isolates, analyzing the full RPO30 and GPCR genes and the partial EEV glycoprotein gene. Results Clinical observations revealed common LSD clinical signs in the affected cattle. PCR and real-time PCR, showed the presence of the LSDV genome in samples from all six districts. Phylogenetic analysis and detailed inspection of multiple sequence alignments revealed that Bangladesh isolates differ from common LSDV field isolates encountered in Africa, the Middle East, and Europe, as well as newly emerged LSDV variants in Russia and China. Instead, they were closely related to LSDV KSGP-0240, LSDV NI2490, and LSDV Kenya. Conclusions These results show the importance of continuous monitoring and characterization of circulating strains and the need to continually refine the strategies for differentiating vaccine strains from field viruses.

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“…Further studies are necessary to clarify the extent to which the naturally altered genotype contributes to changes in the epidemiology of this virus and its putative progeny (Kononov et al, 2020).…”

Section: Ack N Owled G Em Entsmentioning

confidence: 99%

A lumpy skin disease virus which underwent a recombination event demonstrates more aggressive growth in primary cells and cattle than the classical field isolate

Кононова

Кононов

Shumilova

et al. 2020

Transbound Emerg Dis

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Lumpy skin disease (LSD) causes considerable economic losses to cattle producers in endemic countries (Gari, Bonnet, Roger, & Waret-Szkuta, 2011). The aetiological agent is lumpy skin disease virus (LSDV) from the genus Capripoxvirus of the family Poxviridae. Due to the historic geographical restriction to Africa, research on lumpy skin disease virus has been neglected (Tuppurainen et al., 2017).Over the last years, multiple incursions of LSDV have occurred in

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Emergence of a new lumpy skin disease virus variant in Kurgan Oblast, Russia, in 2018

Cited by 22 publications

References 26 publications

Evidence of recombination of vaccine strains of lumpy skin disease virus with field strains, causing disease

Evidence of recombination of vaccine strains of lumpy skin disease virus with field strains, causing disease

Molecular characterization of lumpy skin disease virus (LSDV) emerged in Bangladesh reveals unique genetic features compared to contemporary field strains

A lumpy skin disease virus which underwent a recombination event demonstrates more aggressive growth in primary cells and cattle than the classical field isolate

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