Emergence in Biopharmaceuticals: The Role of Gedunin and Nimbin from Azadirachta indica as a potential cure for SARS CoV-2 and other viral diseases

Abstract

The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Corona virus 2 –SARS CoV- 2 has affected over 170 million people worldwide out of which 3.5 million have lost their lives so far. There is no effective remedy for this highly contagious disease to date. This study examines the effect of Gedunin and Nimbin, one of the constituents of Neem leaves (Azadirachta indica), especially as a possible prophylactic element and a remedy for Covid-19 using computational methods. Other main constituents of the neem leaves such as Azadirachtin and Nimbidin may also work as an active antiviral. This study was initiated by the insights gained from the traditional method of controlling respiratory ailments. We propose ‘Emergence’ as the property that dictates the need to use Gedunin and Nimbin along with the other bioactive components of neem leaves as adjuvants against coronaviruses and other viral diseases