In December 2019, an increasing number of new cases of the new coronavirus (CoV) SARS-CoV-2 associated with pneumonia (COVID-19) have been reported in Wuhan, Hubei Province, China [1-5]. The epidemic did not limit itself only to China, but now it acquired the state of a massive pandemic by hitting more than 200 countries around the globe. In an early study by Chinese Center for Disease Control and Prevention, a total of 5.6% environmental samples from Wuhan South China Seafood Market were found SARS-CoV-2 positive, while some studies also proposed other sources causing infections because some infected individuals had not been exposed to seafood markets [4,6,7,]. Li et al. estimated that SARS-CoV-2 outbreak in Wuhan had probably begun in November 2019 (95% CI, 2019.9.25-2019.12.19) based on analysis of genetic diversity, temporal origin, and evolutionary history [8]. In this tug of war situation to control and prevent SARS-CoV-2, scientists, researcher community and, pharmaceutic industry are putting all their energies and resources to overcome this pandemic.Based on research and data available, we hypothesize that the source of SARS-CoV-2 transmission is semi-wild animals (bamboo rats, mink, pangolins and crickets) reared in farms for human consumption, where they might have infected by the natural virus host (bats). Poor sanitary conditions, carcasses and blood after slaughtering attract rats, stray dogs, and cats, may also promote the spread, recombination and mutation of the virus across different species including humans. This leads us to two questions which may be of great