Emergence and global spread of
            <i>Listeria monocytogenes</i>
            main clinical clonal complex

Moura, Alexandra; Lefrancq, Noémie; Wirth, Thierry; Leclercq, Alexandre; Borges, Vítor; Gilpin, Brent; Dallman, Timothy J.; Frey, Joachim; Franz, Eelco; Nielsen, Eva Møller; Thomas, Juno; Pightling, Arthur W.; Howden, Benjamin P; Tarr, Cheryl L.; Gerner‐Smidt, Peter; Cauchemez, Simon; Salje, Henrik; Brisse, Sylvain; Lecuit, Marc

doi:10.1126/sciadv.abj9805

Cited by 36 publications

(29 citation statements)

References 79 publications

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“…The acquisition of extensive drug resistance and compensatory mutations specifically on top of an already underlying hypervirulent genetic background is likely part of the explanation, as it was already observed for other major pathogens 30 , 38 , 39 . Indeed, the W148 clade is a branch of the so-called “modern” Beijing sublineage L2, which has recently been shown to be characterized by an IS 6110 -linked deletion of the ppe38 gene locus, leading to loss of secretion of substrates of the ESX-5 type VII secretion system and involved in a hypervirulent phenotype 26 .…”

Section: Discussionmentioning

confidence: 76%

Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis

et al. 2022

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Transmission-driven multi-/extensively drug resistant (M/XDR) tuberculosis (TB) is the largest single contributor to human mortality due to antimicrobial resistance. A few major clades of the Mycobacterium tuberculosis complex belonging to lineage 2, responsible for high prevalence of MDR-TB in Eurasia, show outstanding transnational distributions. Here, we determined factors underlying the emergence and epidemic spread of the W148 clade by genome sequencing and Bayesian demogenetic analyses of 720 isolates from 23 countries. We dated a common ancestor around 1963 and identified two successive epidemic expansions in the late 1980s and late 1990s, coinciding with major socio-economic changes in the post-Soviet Era. These population expansions favored accumulation of resistance mutations to up to 11 anti-TB drugs, with MDR evolving toward additional resistances to fluoroquinolones and second-line injectable drugs within 20 years on average. Timescaled haplotypic density analysis revealed that widespread acquisition of compensatory mutations was associated with transmission success of XDR strains. Virtually all W148 strains harbored a hypervirulence-associated ppe38 gene locus, and incipient recurrent emergence of prpR mutation-mediated drug tolerance was detected. The outstanding genetic arsenal of this geographically widespread M/XDR strain clade represents a “perfect storm” that jeopardizes the successful introduction of new anti-M/XDR-TB antibiotic regimens.

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Section: Discussionmentioning

confidence: 76%

Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis

et al. 2022

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“…Interestingly 21% of the CTs here detected were not unique to this study and included genotypes previously detected in the context of listeriosis surveillance in Europe and Oceania (Kwong et al ., 2016; Moura et al ., 2016, 2017, 2021; Hurley et al ., 2019; Painset et al ., 2019) (Table S4). These findings highlight the importance of surveillance programs in farm animals, even in the absence of disease signs, to prevent pathogen transmission to humans through the food chain.…”

Section: Discussionmentioning

confidence: 99%

Ruminant‐associated Listeria monocytogenes isolates belong preferentially to dairy‐associated hypervirulent clones: a longitudinal study in 19 farms

Palacios-Gorba

Moura

Gomis

et al. 2021

Environmental Microbiology

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Studies have shown that ruminants constitute reservoirs of Listeria monocytogenes, but little is known about the epidemiology and genetic diversity of this pathogen within farms. Here we conducted a largescale longitudinal study to monitor Listeria spp. in 19 dairy farms during three consecutive seasons (N = 3251 samples). L. innocua was the most prevalent species, followed by L. monocytogenes. Listeria monocytogenes was detected in 52.6% of farms and more frequently in cattle (4.1%) and sheep (4.5%) than in goat farms (0.2%). Lineage I accounted for 69% of L. monocytogenes isolates. Among animal samples, the most prevalent sublineages (SL) and clonal complexes (CC) were SL1/CC1, SL219/CC4, SL26/CC26 and SL87/CC87, whereas SL666/CC666 was most prevalent in environmental samples. Sixtyone different L. monocytogenes cgMLST types were found, 28% common to different animals and/or surfaces within the same farm and 21% previously reported elsewhere in the context of food and human surveillance. Listeria monocytogenes prevalence was not affected by farm hygiene but by season: higher prevalence was observed during winter in cattle, and during winter and spring in sheep farms. Cows in their second lactation had a higher probability of L. monocytogenes faecal shedding. This study highlights dairy farms as a reservoir for hypervirulent L. monocytogenes.

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“…The majority (91%) of cgMLST types found were unique to this study, reinforcing the importance of comprehensive national surveillance programs to control Listeria transmission ( 45 ). Nevertheless, 10 CTs have been previously reported within the scope of listeriosis surveillance in other countries (Table S3), suggestive of punctual cross-country contaminations or, in the case L1-SL87-ST87-CT58, of contamination sources with large scale distributions.…”

Section: Discussionmentioning

confidence: 55%

Genomic Surveillance of Listeria monocytogenes in Taiwan, 2014 to 2019

Tsai

Moura

et al. 2022

Microbiol Spectr

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Emergence and global spread of Listeria monocytogenes main clinical clonal complex

Abstract: Analyses of ~2000 genomes of Listeria monocytogenes main clinical clone reveal its global spread and dynamics.

Cited by 36 publications

References 79 publications

Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis

Transcontinental spread and evolution of Mycobacterium tuberculosis W148 European/Russian clade toward extensively drug resistant tuberculosis

Ruminant‐associated Listeria monocytogenes isolates belong preferentially to dairy‐associated hypervirulent clones: a longitudinal study in 19 farms

Genomic Surveillance of Listeria monocytogenes in Taiwan, 2014 to 2019

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