Emendation of autophagic dysfuction in neurological disorders: a potential therapeutic target

Sainani, Shivani; Pansare, Prajakta; Rode, Ketki; Bhalchim, Vrushali; Doke, Rohit R; Desai, Shivani

doi:10.1080/00207454.2020.1822356

Cited by 7 publications

(7 citation statements)

References 198 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of the strong interaction between autophagy and neuroplasticity, it is not surprising that changes in autophagy emerged as a pathogenetic mechanism of neurological (first of all neurodegenerative) and some psychiatric disorders ( Tang et al, 2021 ; Filippone et al, 2022 ; Sainani et al, 2022 ). In turn, facilitation of autophagy is more and more recognized and appreciated as an end effector of therapeutic means with pro-cognitive activity ( Tomoda et al, 2020 ).…”

Section: The Link Between Neuroplasticity and Autophagymentioning

confidence: 99%

Neuroplasticity to autophagy cross-talk in a therapeutic effect of physical exercises and irisin in ADHD

Abdulghani

Poghosyan

Mehren

et al. 2023

Front. Mol. Neurosci.

View full text Add to dashboard Cite

show abstract

Section: The Link Between Neuroplasticity and Autophagymentioning

confidence: 99%

Neuroplasticity to autophagy cross-talk in a therapeutic effect of physical exercises and irisin in ADHD

Abdulghani

Poghosyan

Mehren

et al. 2023

Front. Mol. Neurosci.

View full text Add to dashboard Cite

show abstract

“…16 Additionally, OS triggers the accumulation of misfolded proteins within neurons, causing endoplasmic reticulum stress and subsequent activation of autophagy. 17 OS doesn't solely impact neurons; it also affects other components of the CNS, such as astrocytes. Astrocytes, which contribute to inflammatory responses and immunity within the CNS, undergo inflammation and astrogliosis due to OS.…”

Section: Oxidative Stress Cns and Neurodegenerative Disordersmentioning

confidence: 99%

Oxidative stress and neurodegenerative diseases: Exploring natural antioxidants for therapeutic potential

Doke,

Kallur,

Suryawanshi

et al. 2023

IJCAAP

Self Cite

View full text Add to dashboard Cite

Neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's, are a growing global health challenge with no definitive cure. Oxidative stress is implicated in these disorders, and antioxidants have emerged as a promising avenue for addressing them. Research has shown the potential of natural antioxidants to combat oxidative stress in neurodegenerative disorders, but clinical trials have often failed to treat patients effectively. However, natural extracts have shown diverse molecular activities beyond their antioxidant capabilities, indicating their potential for prevention and disease management. This review will explore in vitro and in vivo research studies to highlight the promising prospects of natural antioxidants and their therapeutic applications in Neurodegenerative conditions.

show abstract

“…Autophagy is also induced by starvation [ 64 ]. In this way, autophagy is important for cells by providing them with essential nutrients [ 65 , 66 ].…”

Section: Autophagy and Admentioning

confidence: 99%

Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia

Eshraghi

Adlimoghaddam

Mahmoodzadeh

et al. 2021

IJMS

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a debilitating neurological disorder, and currently, there is no cure for it. Several pathologic alterations have been described in the brain of AD patients, but the ultimate causative mechanisms of AD are still elusive. The classic hallmarks of AD, including am-yloid plaques (Aβ) and tau tangles (tau), are the most studied features of AD. Unfortunately, all the efforts targeting these pathologies have failed to show the desired efficacy in AD patients so far. Neuroinflammation and impaired autophagy are two other main known pathologies in AD. It has been reported that these pathologies exist in AD brain long before the emergence of any clinical manifestation of AD. Microglia are the main inflammatory cells in the brain and are considered by many researchers as the next hope for finding a viable therapeutic target in AD. Interestingly, it appears that the autophagy and mitophagy are also changed in these cells in AD. Inside the cells, autophagy and inflammation interact in a bidirectional manner. In the current review, we briefly discussed an overview on autophagy and mitophagy in AD and then provided a comprehensive discussion on the role of these pathways in microglia and their involvement in AD pathogenesis.

show abstract

Emendation of autophagic dysfuction in neurological disorders: a potential therapeutic target

Cited by 7 publications

References 198 publications

Neuroplasticity to autophagy cross-talk in a therapeutic effect of physical exercises and irisin in ADHD

Neuroplasticity to autophagy cross-talk in a therapeutic effect of physical exercises and irisin in ADHD

Oxidative stress and neurodegenerative diseases: Exploring natural antioxidants for therapeutic potential

Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia

Contact Info

Product

Resources

About