Abstract:Mircoglia are specialized mononuclear phagocytes within the central nervous system (CNS). Their embryonic origins and routes of entry to the CNS remain controversial. In this study, we used Iba1 as a specific marker for microglial progenitors in mouse embryos and employed multiple immunohistochemical localization and tissue transplantation to establish (1) their routes of entry to the CNS and (2) their origin. Iba1+ microglial progenitors were found in the mesenchyme at E9.5, and started to appear in the neura… Show more
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