Embryonic origin and lineage of juxtaglomerular cells

López, María Luisa S. Sequeira; Pentz, Ellen S.; Robert, Barry; Abrahamson, Dale R.; Gómez, R. Ariel

doi:10.1152/ajprenal.2001.281.2.f345

Cited by 123 publications

(61 citation statements)

References 32 publications

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“…In nephrogenesis, single RLCs were first observed at e14, which is in agreement with previous reports. 28–32 RLCs forming a discernible cell population were detected by flow cytometry in all studied embryonic kidneys not earlier than e16, which is also consistent with current knowledge. 1,31 During embryo-genesis, (e16 to pp1), the percentage of RLCs doubled.…”

Section: Discussionsupporting

confidence: 92%

Persistent and inducible neogenesis repopulates progenitor renin lineage cells in the kidney

Hickmann

Steglich

Gerlach

et al. 2017

Kidney International

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Renin lineage cells (RLCs) serve as a progenitor cell reservoir during nephrogenesis and after renal injury. The maintenance mechanisms of the RLC pool are still poorly understood. Since RLCs were also identified as a progenitor cell population in bone marrow we first considered that these may be their source in the kidney. However, transplantation experiments in adult mice demonstrated that bone marrow-derived cells do not give rise to RLCs in the kidney indicating their non-hematopoietic origin. Therefore we tested whether RLCs develop in the kidney through neogenesis (de novo differentiation) from cells that have never expressed renin before. We used a murine model to track neogenesis of RLCs by flow cytometry, histochemistry, and intravital kidney imaging. During nephrogenesis RLCs first appear at e14, form a distinct population at e16, and expand to reach a steady state level of 8–10% of all kidney cells in adulthood. De novo differentiated RLCs persist as a clearly detectable population through embryogenesis until at least eight months after birth. Pharmacologic stimulation of renin production with enalapril or glomerular injury induced the rate of RLC neogenesis in the adult mouse kidney by 14% or more than three-fold, respectively. Thus, the renal RLC niche is constantly filled by local de novo differentiation. This process could be stimulated consequently representing a new potential target to beneficially influence repair and regeneration after kidney injury.

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Section: Discussionsupporting

confidence: 92%

Persistent and inducible neogenesis repopulates progenitor renin lineage cells in the kidney

Hickmann

Steglich

Gerlach

et al. 2017

Kidney International

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“…Developmentally, renin-producing cells are derived from the metanephric mesenchyme 44 . Sequeira Lopez et al.…”

Section: Discussionmentioning

confidence: 99%

Human kidney pericytes produce renin

Stefanska

Kenyon

Christian

et al. 2016

Kidney International

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Pericytes, perivascular cells embedded in the microvascular wall, are crucial for vascular homeostasis. These cells also play diverse roles in tissue development and regeneration as multi-lineage progenitors, immunomodulatory cells and as sources of trophic factors. Here, we establish that pericytes are renin producing cells in the human kidney. Renin was localized by immunohistochemistry in CD146 and NG2 expressing pericytes, surrounding juxtaglomerular and afferent arterioles. Similar to pericytes from other organs, CD146+CD34–CD45–CD56– renal fetal pericytes, sorted by flow cytometry, exhibited tri-lineage mesodermal differentiation potential in vitro. Additionally, renin expression was triggered in cultured kidney pericytes by cyclic AMP as confirmed by immuno-electron microscopy, and secretion of enzymatically functional renin, capable of generating angiotensin I. Pericytes derived from second trimester human placenta also expressed renin in an inducible fashion although the renin activity was much lower than in renal pericytes. Thus, our results confirm and extend the recently discovered developmental plasticity of microvascular pericytes, and may open new perspectives to the therapeutic regulation of the renin-angiotensin system.

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“…By embryonic day 15.5, renin is detected in the developing renal artery, interlobar arteries, and arcuate arteries of the metanephric kidney (262). Yet, lineage tracing studies using the Ren1 d promoter have suggested that renin producing cells originating from mesenchymal precursors can be identified around embryonic day 11.5 days before vessel development (331). As development progresses, renin expression is found in newly developed afferent arterioles while it disappears from interlobular arteries around the time of birth (315).…”

Section: Renin Expression During Kidney Developmentmentioning

confidence: 99%

Classical Renin‐Angiotensin System in Kidney Physiology

Sparks

Crowley

Gurley

et al. 2014

Comprehensive Physiology

439

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The renin-angiotensin system has powerful effects in control of the blood pressure and sodium homeostasis. These actions are coordinated through integrated actions in the kidney, cardio-vascular system and the central nervous system. Along with its impact on blood pressure, the renin-angiotensin system also influences a range of processes from inflammation and immune responses to longevity. Here, we review the actions of the “classical” renin-angiotensin system, whereby the substrate protein angiotensinogen is processed in a two-step reaction by renin and angiotensin converting enzyme, resulting in the sequential generation of angiotensin I and angiotensin II, the major biologically active renin-angiotensin system peptide, which exerts its actions via type 1 and type 2 angiotensin receptors. In recent years, several new enzymes, peptides, and receptors related to the renin-angiotensin system have been identified, manifesting a complexity that was previously unappreciated. While the functions of these alternative pathways will be reviewed elsewhere in this journal, our focus here is on the physiological role of components of the “classical” renin-angiotensin system, with an emphasis on new developments and modern concepts.

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Embryonic origin and lineage of juxtaglomerular cells

Cited by 123 publications

References 32 publications

Persistent and inducible neogenesis repopulates progenitor renin lineage cells in the kidney

Persistent and inducible neogenesis repopulates progenitor renin lineage cells in the kidney

Human kidney pericytes produce renin

Classical Renin‐Angiotensin System in Kidney Physiology

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