Embryonic Neural Stem Cell Differentiation to Aldynoglia Induced by Olfactory Bulb Ensheathing Cell-Conditioned Medium

Ortuño-Sahagún, Daniel; Rojas-Mayorquín, Argelia E.; Camins, Antoni; Pallàs, Mercè

doi:10.5772/15239

Cited by 2 publications

(3 citation statements)

References 99 publications

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“…Aldynoglia could be a plausible alternative in cell therapy because is a glial cell that promotes axonal growth and remyelination in SCI models [58]. These cells arise from different niches in the brain and spinal cord [5,28,59] (Figure 1) and they have these in common that can differentiate into ensheathing cells, promoting remyelination and axonal out-growth [5,6,8].…”

Section: Effect Of Aldynoglia Cells On Regeneration After Scimentioning

confidence: 99%

“…The close relationship between glial cells and neurons is of great importance for the functioning of CNS, both for myelination and the transmission of neurotransmitters, even if they come from a different progeny of precursor cells [6]. Neurons and glial cells come from neuroectoderm, the precursors of glial cells will be found in both the ventricular and subventricular areas from where they migrate to more specific regions using neuron-like signals [7].…”

Section: Introductionmentioning

confidence: 99%

“…The highest percentage of glial cells in the brain are astrocytes and oligodendrocytes, but there are other types of glial cells such as radial glia, Müller glia cells, Bergman glial cells, pituicytes, tanycytes, and olfactory ensheathing cells. In addition, in the spinal cord are the ependymal cells, tanycytes, and cells of the central canal; together they are called aldynoglia cells, which remain in adulthood [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Role of Aldynoglia Cells in Neuroinflammatory and Neuroimmune Responses after Spinal Cord Injury

Buzoianu-Anguiano

Torres-Llacsa

Doncel‐Pérez

2021

Cells

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Aldynoglia are growth-promoting cells with a morphology similar to radial glia and share properties and markers with astrocytes and Schwann cells. They are distributed in several locations throughout the adult central nervous system, where the cells of the aldynoglia interact and respond to the signals of the immune cells. After spinal cord injury (SCI), the functions of resident aldynoglia, identified as ependymocytes, tanycytes, and ependymal stem cells (EpSCs) of the spinal cord are crucial for the regeneration of spinal neural tissue. These glial cells facilitate axonal regrowth and remyelination of injured axons. Here, we review the influence of M1 or M2 macrophage/microglia subpopulations on the fate of EpSCs during neuroinflammation and immune responses in the acute, subacute, and chronic phases after SCI.

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Section: Effect Of Aldynoglia Cells On Regeneration After Scimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Role of Aldynoglia Cells in Neuroinflammatory and Neuroimmune Responses after Spinal Cord Injury

Buzoianu-Anguiano

Torres-Llacsa

Doncel‐Pérez

2021

Cells

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Ensheathing cell-conditioned medium directs the differentiation of human umbilical cord blood cells into aldynoglial phenotype cells

et al. 2012

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Despite their similarities to bone marrow precursor cells (PC), human umbilical cord blood (HUCB) PCs are more immature and, thus, they exhibit greater plasticity. This plasticity is evident by their ability to proliferate and spontaneously differentiate into almost any cell type, depending on their environment. Moreover, HUCB-PCs yield an accessible cell population that can be grown in culture and differentiated into glial, neuronal and other cell phenotypes. HUCB-PCs offer many potential therapeutic benefits, particularly in the area of neural replacement. We sought to induce the differentiation of HUCB-PCs into glial cells, known as aldynoglia. These cells can promote neuronal regeneration after lesion and they can be transplanted into areas affected by several pathologies, which represents an important therapeutic strategy to treat central nervous system damage. To induce differentiation to the aldynoglia phenotype, HUCB-PCs were exposed to different culture media. Mononuclear cells from HUCB were isolated and purified by identification of CD34 and CD133 antigens, and after 12 days in culture, differentiation of CD34+ HUCB-PCs to an aldynoglia phenotypic, but not that of CD133+ cells, was induced in ensheathing cell (EC)-conditioned medium. Thus, we demonstrate that the differentiation of HUCB-PCs into aldynoglia cells in EC-conditioned medium can provide a new source of aldynoglial cells for use in transplants to treat injuries or neurodegenerative diseases.

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Embryonic Neural Stem Cell Differentiation to Aldynoglia Induced by Olfactory Bulb Ensheathing Cell-Conditioned Medium

Cited by 2 publications

References 99 publications

Role of Aldynoglia Cells in Neuroinflammatory and Neuroimmune Responses after Spinal Cord Injury

Role of Aldynoglia Cells in Neuroinflammatory and Neuroimmune Responses after Spinal Cord Injury

Ensheathing cell-conditioned medium directs the differentiation of human umbilical cord blood cells into aldynoglial phenotype cells

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