Embryonic inhibition of colony‐stimulating factor 1 receptor induces enlarged cartilaginous zone of the midpalatal suture in postnatal mice
Lai Yongzhen,
Guo yan,
Liu Jing
et al.
Abstract:ObjectivesThe midpalatal suture acts as the growth centre of the maxilla. Colony‐stimulating factor 1 receptor (CSF1R) is essential for osteoclastogenesis. Deletion of CSF1R, and its ligand, results in significant craniofacial phenotypes but has not been studied in detail in the midpalatal suture.Materials and MethodsPregnant ICR mice were treated with the CSF1R inhibitor PLX5622 at embryo Day 14.5 (E14.5) to E17.5. Pups at E18.5, postnatal Day 3 (P3) and P7 were collected for skeletal and histological stainin… Show more
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