2014
DOI: 10.18632/aging.100712
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Abstract: Despite the progress in aging research that highlights the role of the nervous system in longevity, whether genes that control development and consequently structure of the nervous system affect lifespan is unclear. We demonstrated that a mutation in shuttle craft, a gene involved in the nervous system development, increased the lifespan of unmated females and decreased the lifespan of mated females, without affecting males. Precise reversions of the mutation lead to the restoration of the lifespan specific to… Show more

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Cited by 12 publications
(19 citation statements)
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References 32 publications
(44 reference statements)
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“…Of note, the only esg mutation associated with an increased life span was in a slightly different genetic background compared with the mutations associated with decreased life span, which indicate unknown epistatic interactions (Magwire et al, 2010 ). This evidence agrees with our data showing that the mutations in shuttle craft had different effects on life span in different genetic backgrounds (Pasyukova et al, 2004 ; Roshina et al, 2014 ) and the data from other researchers. For example, naturally segregating genes interact epistatically with Sod , a well-known aging gene, to modify its ability to extend longevity (Spencer et al, 2003 ).…”
Section: Discussionsupporting
confidence: 93%
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“…Of note, the only esg mutation associated with an increased life span was in a slightly different genetic background compared with the mutations associated with decreased life span, which indicate unknown epistatic interactions (Magwire et al, 2010 ). This evidence agrees with our data showing that the mutations in shuttle craft had different effects on life span in different genetic backgrounds (Pasyukova et al, 2004 ; Roshina et al, 2014 ) and the data from other researchers. For example, naturally segregating genes interact epistatically with Sod , a well-known aging gene, to modify its ability to extend longevity (Spencer et al, 2003 ).…”
Section: Discussionsupporting
confidence: 93%
“…Sex-specific and sex-antagonistic effects on life span are not rare (Tricoire et al, 2009 ; Ruiz et al, 2011 ; Roshina et al, 2014 ; Schriner et al, 2014 ; Shaposhnikov et al, 2015 ); for example, of 59 mutations increasing life span, 70.7% affected males and females differently (Magwire et al, 2010 ). In the initial screens and in our first experiment (Magwire et al, 2010 ), the effects of esg BG01042 on the life span of female flies were not statistically significant leading to the conclusion that esg BG01042 affects life span in a male-specific manner.…”
Section: Resultsmentioning
confidence: 99%
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