Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions

Hellmich, Helen L.; Kos, Lidia; Cho, Edward S.; Mahon, Kathleen; Zimmer, Andreas

doi:10.1016/0925-4773(95)00464-5

Cited by 223 publications

(127 citation statements)

References 33 publications

Supporting

Mentioning

121

Contrasting

Order By: Relevance

“…GDNF7/7 mice have similar phenotypic characteristics to their RET7/7 counterparts: kidney agenesis or severe dysgenesis and absence of the enteric ganglia (SaÂ nchez et al, 1996;Moore et al, 1996;Pichel et al, 1996). Consistent with RET's proposed role as a transducer of mesenchyme-derived signals in kidney induction, GDNF expression has been localized to the metanephric mesenchyme (Hellmich et al, 1996).…”

Section: Introductionmentioning

confidence: 71%

The expression of RET and its multiple splice forms in developing human kidney

et al. 1997

View full text Add to dashboard Cite

A series of inductive events between two di erent cell groups, the ureteric bud epithelium and metanephric mesenchyme, gives rise to the functional mammalian kidney. These reciprocal inductive interactions involve a number of molecules, one of which is the RET receptor tyrosine kinase. The phenotype of mice lacking functional RET includes kidney agenesis or severe dysgenesis, indicating a requirement for RET in kidney organogenesis. To investigate RET expression in human kidney development, we used a semi-quantitative RT ± PCR-based strategy to examine a panel of kidney RNA samples ranging from 8 ± 24 weeks gestational age. We found RET expression was highest earlier in development (14 weeks) with expression decreasing through to 24 weeks gestation. While three alternative RET transcripts generated by exon skipping at the 5' end of the gene were all detected throughout kidney development, expression of one transcript, RET2/6, where exon 2 was spliced to exon 6, varied relative to full length RET during this period. Levels of RET2/6 were highest at the earliest age of fetal kidney examined (8 weeks) and decreased relative to all other RET transcripts to low adult levels. The period of high expression coincides with a period of rapid bud bifurcation. Thus, it is possible that RET2/6 has a role in the early growth and di erentiation of the human kidney.

show abstract

Section: Introductionmentioning

confidence: 71%

The expression of RET and its multiple splice forms in developing human kidney

et al. 1997

View full text Add to dashboard Cite

show abstract

“…Our understanding of the mammalian spermatogonial stem cell niche has recently greatly progressed with the discovery that glial cell line-derived neurotrophic factor (Gdnf), a neurotropic factor secreted by glial cells in the brain, is also expressed in other organs during development, including ovary and testis Hellmich et al, 1996;Trupp et al, 1995;Golden et al, 1999). Gdnf, secreted by Sertoli cells after birth, is so far the only known paracrine factor in the testis specifically responsible for the maintenance and selfrenewal of SSCs in vivo and in vitro (Meng et al, 2000;Kubota et al, 2004b;Hofmann et al, 2005b).…”

Section: Spermatogenesis and The Spermatogonial Stem Cell Nichementioning

confidence: 99%

“…Because it improves motor functions in animal models of parkinsonism, Gdnf has been seen as a promising therapy for Parkinson disease (Grondin and Gash, 1998). The role of Gdnf in embryonic development is not limited to the nervous system and it is also essential for kidney and gastrointestinal tract formation (Schuchardt et al, 1994;Moore et al, 1996;Hellmich et al, 1996). Cloning of Gdnf revealed that it is a distant member of the transforming growth factor beta (Tgf-β) superfamily (Lin et al, 1993).…”

Section: Role Of Gdnf In the Mammalian Testismentioning

confidence: 99%

Gdnf signaling pathways within the mammalian spermatogonial stem cell niche

Hofmann

2008

Molecular and Cellular Endocrinology

203

178

View full text Add to dashboard Cite

SummaryMammalian spermatogenesis is a complex process in which male germ-line stem cells develop to ultimately form spermatozoa. Spermatogonial stem cells, or SSCs, are found in the basal compartment of the seminiferous epithelium. They self-renew to maintain the pool of stem cells throughout life, or they differentiate to generate a large number of germ cells. A balance between SSC self-renewal and differentiation in the adult testis is therefore essential to maintain normal spermatogenesis and fertility. Maintenance and self-renewal are tightly regulated by extrinsic signals from the surrounding microenvironment, called the spermatogonial stem cell niche. By physically supporting the SSCs and providing them with growth factors, the Sertoli cell is the main component of the niche. In addition, adhesion molecules that connect the SSCs to the basement membrane and cellular components of the interstitium between the seminiferous tubules are important regulators of the niche function. This review mainly focuses on glial cell line-derived neurotrophic factor (Gdnf), which is produced by Sertoli cells to maintain SSCs self-renewal, and the downstream signaling pathways induced by this crucial growth factor. Interactions between Gdnf and other signaling pathways that maintain self-renewal, as well as the role of novel SSC-and Sertoli cell-specific transcription factors, are also discussed.

show abstract

“…EGCs could therefore contribute to the development of the enteric neuronal network (Bä r et al, 1997;Gershon, 1999) and to neuroprotection. However, EGCs are not the primary source of GDNF in the developing gut as GDNF is expressed as early as E9.0 in the mouse gut (Hellmich et al, 1996), although differentiated EGCs first appear at E16 (Rothman et al, 1986).…”

Section: Neuroprotective and Neuromodulatory Functions Of Egcmentioning

confidence: 99%

Role of enteric glial cells in inflammatory bowel disease

Cabarrocas

Savidge

Liblau

2002

Glia

159

154

View full text Add to dashboard Cite

Enteric glial cells (EGCs) represent an extensive but relatively poorly described cell population within the gastrointestinal tract. Accumulating data suggest that EGCs represent the morphological and functional equivalent of CNS astrocytes within the enteric nervous system (ENS). The EGC network has trophic and protective functions toward enteric neurons and is fully implicated in the integration and the modulation of neuronal activities. Moreover, EGCs seem to be active elements of the ENS during intestinal inflammatory and immune responses, sharing with astrocytes the ability to act as antigen-presenting cells and interacting with the mucosal immune system via the expression of cytokines and cytokine receptors. Transgenic mouse systems have demonstrated that specific ablation of EGC by chemical ablation or autoimmune T-cell targeting induces an intestinal pathology that shows similarities to the early intestinal immunopathology of Crohn's disease. EGCs may also share with astrocytes the ability to regulate tissue integrity, thereby postulating that similar interactions to those observed for the blood-brain barrier may also be partly responsible for regulating mucosal and vascular permeability in the gastrointestinal tract. Disruption of the EGC network in Crohn's disease patients may represent one possible cause for the enhanced mucosal permeability state and vascular dysfunction that are thought to favor mucosal inflammation. GLIA 41:81-93, 2003.

show abstract

Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions

Cited by 223 publications

References 33 publications

The expression of RET and its multiple splice forms in developing human kidney

The expression of RET and its multiple splice forms in developing human kidney

Gdnf signaling pathways within the mammalian spermatogonial stem cell niche

Role of enteric glial cells in inflammatory bowel disease

Contact Info

Product

Resources

About