Embryonic exposure of medaka (Oryzias latipes) to propylparaben: Effects on early development and post-hatching growth

González-Doncel, Miguel; García-Mauriño, José Enrique; San-Segundo, Laura; Beltrán, Eulalia María; Sastre, Salvador; Torija, Carlos Fernández

doi:10.1016/j.envpol.2013.09.022

Cited by 28 publications

(17 citation statements)

References 36 publications

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“…It is reported that PHBA can also cause physiological estrogenic responses (Boberg et al 2010;Dobbins et al 2009;Gonzalez-Doncel et al 2014). Although it is less toxic than parabens (Ishiwatari et al 2007), the relative high level of PHBA in swimming pools cannot be neglected.…”

Section: Resultsmentioning

confidence: 99%

Occurrence and human exposure of parabens and their chlorinated derivatives in swimming pools

Shi

Gao

et al. 2015

Environ Sci Pollut Res

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As an emerging group of endocrine-disrupting chemicals, parabens have attracted growing attention due to their potential effects on human health. In the present study, the occurrence and distribution of eight parabens, four chlorinated parabens, and their common hydrolysis product, phydroxybenzoic acid (PHBA), were investigated in 39 swimming pools in Beijing, China. Methyl paraben and propyl paraben were the predominant compounds in swimming pools, accounting for 91.2 % of the total parabens. It is noteworthy that octyl paraben, a paraben with longer chain, was firstly detected in this study. There were several factors affecting the levels of parabens among the 39 swimming pools. The concentrations of parabens and chlorinated derivatives detected in indoor pools (144 ng L −1 ) were roughly 20-fold higher than those in outdoor pools (6.78 ng L −1 ). Hotel pools appear to present higher level of target compounds (361 ng L −1 ) than that in health club (228 ng L −1 ), municipal (130 ng L −1 ), school (75.6 ng L −1 ), and community pools (63.0 ng L −1 ). Moreover, the level of these compounds in pools during weekends (174 ng L −1 ) was much higher than that during weekdays (52.3 ng L −1 ). The dynamics of target compounds were also investigated to provide a general trend of the level of parabens in a school indoor swimming pool during a 14-week period. Human exposure assessment was conducted to estimate the potential risk of exposure to parabens and their chlorinated derivatives in swimming pools. Considering the total exposure dose of multiple parabens, human exposure to parabens from the water of swimming pools is negligible. However, the threat of these parabens to children in swimming pool should be concerned.

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Section: Resultsmentioning

confidence: 99%

Occurrence and human exposure of parabens and their chlorinated derivatives in swimming pools

Shi

Gao

et al. 2015

Environ Sci Pollut Res

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“…In a recent study, González-Doncel et al exposed Oryzias latipes (Temminck and Schlegel, 1846) embryos to several concentrations of propylparaben and examined physiological and anatomical abnormalities in embryos, eleutheroembryos (13 days post-fertilization—dpf) and larvae (42 dpf) [36]. No early or late toxic effects were observed at concentrations bellow 1 mg/L propylparaben.…”

Section: Discussionmentioning

confidence: 99%

Screening the Toxicity of Selected Personal Care Products Using Embryo Bioassays: 4-MBC, Propylparaben and Triclocarban

Torres

Cunha

Martíns

et al. 2016

IJMS

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Recently, several emerging pollutants, including Personal Care Products (PCPs), have been detected in aquatic ecosystems, in the ng/L or µg/L range. Available toxicological data is limited, and, for certain PCPs, evidence indicates a potential risk for the environment. Hence, there is an urgent need to gather ecotoxicological data on PCPs as a proxy to improve risk assessment. Here, the toxicity of three different PCPs (4-Methylbenzylidene Camphor (4-MBC), propylparaben and triclocarban) was tested using embryo bioassays with Danio rerio (zebrafish) and Paracentrotus lividus (sea urchin). The No Observed Effect Concentration (NOEC) for triclocarban was 0.256 µg/L for sea urchin and 100 µg/L for zebrafish, whereas NOEC for 4-MBC was 0.32 µg/L for sea urchin and 50 µg/L for zebrafish. Both PCPs impacted embryo development at environmentally relevant concentrations. In comparison with triclocarban and 4-MBC, propylparaben was less toxic for both sea urchin (NOEC = 160 µg/L) and zebrafish (NOEC = 1000 µg/L). Overall, this study further demonstrates the sensitivity of embryo bioassays as a high-throughput approach for testing the toxicity of emerging pollutants.

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“…Considering the structure of target parabens, OcP with the longest chains showed the strongest estrogenic activity and persistence in the environment [18]. It is reported that removal of the ester group from parabens does not eliminate their estrogenic activity, and their main metabolite product, PHBA, can also give estrogenic responses [19,20]. Therefore, PHBA can be still regarded as estrogenic, so its occurrence and fate should be included in future studies.…”

Section: Introductionmentioning

confidence: 99%

Occurrence, fate and risk assessment of parabens and their chlorinated derivatives in an advanced wastewater treatment plant

Shi

Gao

et al. 2015

Journal of Hazardous Materials

144

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Embryonic exposure of medaka (Oryzias latipes) to propylparaben: Effects on early development and post-hatching growth

Cited by 28 publications

References 36 publications

Occurrence and human exposure of parabens and their chlorinated derivatives in swimming pools

Occurrence and human exposure of parabens and their chlorinated derivatives in swimming pools

Screening the Toxicity of Selected Personal Care Products Using Embryo Bioassays: 4-MBC, Propylparaben and Triclocarban

Occurrence, fate and risk assessment of parabens and their chlorinated derivatives in an advanced wastewater treatment plant

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