Embryonal rhabdomyosarcoma of the lung arising in cystic adenomatoid malformation: Case report and review of the literature

D’Agostino, Stefania; Bonoldi, Emanuela; Dante, S; Deli, S; Cappellari, F; Musi, L

doi:10.1016/s0022-3468(97)90329-8

Cited by 119 publications

(44 citation statements)

References 16 publications

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“…Beyond the neonatal period the main risk is infection [1][2][3][4], which may greatly complicate an eventual resection. The risk of malignant transformation is also real [37][38][39][40] and there is a small risk of spontaneous pneumothorax [41]. Since CCAM does not regress postnatally [42] and since these risks span over decades precluding close follow-up of these patients, simple observation seems hazardous.…”

Section: Discussionmentioning

confidence: 99%

Outcome of the Prenatally Diagnosed Congenital Cystic Adenomatoid Lung Malformation: A Canadian Experience

et al. 2001

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Congenital cystic adenomatoid malformation of the lung (CCAM) is diagnosed by prenatal ultrasonography with an increasing frequency but controversy persists as to its prognosis and prenatal management. Method: A multi-institutional study of cases of CCAM diagnosed antenatally identified by ultrasonographers and by a review of hospital charts. Results: We obtained 48 cases from five centers. We estimate the incidence of CCAM at 1:25,000 to 1:35,000 pregnancies. The incidence of voluntary abortions was 15% (7/48), of spontaneous abortions 2% (1/41) and of postnatal death 10% (4/40). One of the postnatal deaths was from trisomy 18. Of the 7 aborted fetuses, 2 had multiple malformations and 1 had severe hydrops and oligohydramnios; the other 4 had a large mass with mediastinal displacement but without hydrops. When pregnancy was allowed to continue, 56% of the lesions regressed spontaneously, even though one third of these had initial progression. In 17 cases (42%) the mediastinal shift corrected itself, sometimes by simple growth of the fetus but most often by a decrease in the size of the lung mass. In 1 fetus, repeated needle decompressions followed by double-pigtail catheter drainage of large cysts allowed regression of hydrops. Despite this, neonatal death occurred from pulmonary hypoplasia. Conclusion: CCAM can lead to fetal or neonatal demise from hydrops, lung hypoplasia, prematurity or severe associated malformations, but has a good prognosis in the majority of cases.

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Section: Discussionmentioning

confidence: 99%

Outcome of the Prenatally Diagnosed Congenital Cystic Adenomatoid Lung Malformation: A Canadian Experience

et al. 2001

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“…Proponents of early surgical intervention argue for the possible discordance between presumptive radiological diagnosis and final pathological diagnosis, risk of recurrent infections, pneumothorax and delayed malignant transformation, particularly in CCAM [9] whereas those who support serial observation question the safety of pulmonary resection in infancy and childhood.…”

Section: Case Reportmentioning

confidence: 99%

Congenital Lung Lesions (CLL): Postnatal Management: Operative Intervention or Serial Observation: A Review of 2 Cases

Dipak¹,

Shetty²,

Rao³

et al. 2016

IJIMS

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“…There are a small number of published cases of malignancy associated with presumed congenital cystic lung disease [5,6,59,60,61]. It has been postulated because of this that BPFM possess premalignant potential and in some centres all lesions with the appearance of CCAM are removed because of this.…”

Section: Treatmentmentioning

confidence: 99%

“…Improvements in fetal intervention and surgery, combined with a desire to reduce the number of terminations in affected fetuses, have necessarily led to further consideration of the antenatal progress and prognosis of cystic lung lesions. In addition, several authors have reported cases of malignancy that appeared to arise from congenital cystic lung lesions [1,2,3,4,5,6]. The radiological diagnosis and assessment of these lesions has therefore become ever more important.…”

Section: Introductionmentioning

confidence: 99%

Bronchopulmonary foregut malformations: embryology, radiology and quandary

Barnes

Pilling

2003

European Radiology

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Bronchopulmonary foregut malformations (BPFM) are a heterogeneous group of pulmonary developmental anomalies that present at varying ages and with overlapping symptoms, signs and radiology. This article discusses the embryology of these lesions with reference to possible common origins and the link between aetiology and radiological appearance. The radiology of each lesion, both antenatally and postnatally, is described and illustrated. A number of quandaries exist in the prediction of prognosis and subsequent treatment of BPFM. We discuss the radiological features that may help to elucidate an individual prognosis and aid in the planning of treatment. The treatment options available for BPFM are briefly discussed. Finally, the link between BPFM, in particular cystic adenomatoid malformations and malignancy, is discussed. We aim to provide a comprehensive overview of the embryology, radiology, prognosis and treatment highlighting contentious issues of BPFM.

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Embryonal rhabdomyosarcoma of the lung arising in cystic adenomatoid malformation: Case report and review of the literature

Cited by 119 publications

References 16 publications

Outcome of the Prenatally Diagnosed Congenital Cystic Adenomatoid Lung Malformation: A Canadian Experience

Outcome of the Prenatally Diagnosed Congenital Cystic Adenomatoid Lung Malformation: A Canadian Experience

Congenital Lung Lesions (CLL): Postnatal Management: Operative Intervention or Serial Observation: A Review of 2 Cases

Bronchopulmonary foregut malformations: embryology, radiology and quandary

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