Embryonal rhabdomyosarcoma in adults

Abstract

A series of 54 cases of embryonal rhabdomyosarcomas in adults were studied. The neoplasms were classified according to anatomic site, size, histologic pattern, age, and sex of the patients and modality of treatment. The major anatomic sites were the extremities (21 cases), genitourinary organs (13 cases) and the trunk (nine cases). The overall five-year survival rate was 21% but 79% of the patients were dead at an average time of 17 months after the primary diagnosis was made. On the other hand, 80% of the patients with Stage I1 disease (tumor size < 5 cm) survived five years. In general, patients who were treated with surgery only or surgery and radiation or chemotherapy did much better than patients treated with chemotherapy and/or radiation therapy only. When the rate of recurrences, metastasis and time of death due to spread of neoplasm was compared in cases diagnosed between 1950-1969 and 1970-1978, patients in the last nine years had fewer recurrences, less metastases and better survival than those who had their neoplasm diagnosed and treated between 1950 and 1969.Cancer 51557-565, 1983.MBRYONAL RHABDOMYOSARCOMA is generally re-E garded as a neoplasm occurring primarily during childhood, although there have been a few reports of this neoplasm in adults.'V2 The impression that anatomic presentation and response of embryonal rhabdomyosarcoma to therapy is different from that of childhood embryonal rhabdomyosarcoma prompted this study. It is hoped that consideration of clinical presentation and prognosis together with gross and histologic appearance will contribute to better understanding of these neoplasms in adults.

Outcome of 449 adult patients with rhabdomyosarcoma: an observational ambispective nationwide study

“…The relapse rate is consistent with that reported in the literature: 33–57% local relapses 11, 12, 13, 14, 19 and up to 48–68% metastatic relapse 14, 16, 19. It is observed often during the first year, leading to death in 6–12 months 11, 12, 14, 15, 16, 17, 19, with median survival of 9, 8, and 7 months for patients with local relapse, metastatic relapse, or both in the present work. This outcome is notably inferior to that achieved in other ASTS of adults in 2016.…”

“…But in our study, patients older than 25 years received significantly less chemotherapy and numerous treatments. Surgical results were consistent with those previously reported 11, 12, 13, 15, 16, 17, 18, 19. The absence of surgery and incomplete resection were deleterious for OS.…”

Clinical Outcome of Rhabdomyosarcoma in Adolescent and Adult Patients: Single Center Experience from Turkey

“…Adult patients with embryonal RMS were reported have an overall 5-year survival rate of 21% in one retrospective study. Of note, majority of patients (79%) were dead after an average time of 17 months after diagnosis (Llyod et al 1983). Joshi at al also were reported that adolescent RMS patients had worse prognosis.…”

Bone Marrow Metastasis of Rhabdomyosarcoma Mimicking Acute Leukemia: A Case Report and Review of the Literature

“…As in the present case, bone marrow metastasis of rhabdomyosarcoma of head and neck origin is not thought to be rare. However, the prognosis of metastatic cases is poor (17)(18)(19), with a five-year event-free survival rate of <30% (12), and outcomes are usually worse in adults than children (20,21).…”