Embryology of the Female Reproductive Tract

Healey, Andrew

doi:10.1007/174_2010_128

Cited by 19 publications

(12 citation statements)

References 3 publications

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“…The uterus develops embryologically from the paramesonephric ducts (also referred to as the Mullerian ducts), which in the absence of the Mullerian inhibiting factor, present typically in males, proliferate and differentiate and give rise to the fallopian tubes, uterus, and upper third of the vaginal canal [ 21 ]. In endometriosis, the endometrial tissues spread from the uterus to other pelvic organs, such as the ovaries and fallopian tubes [ 1 - 2 ].…”

Section: Reviewmentioning

confidence: 99%

The Clinical Anatomy of Endometriosis: A Review

Alimi¹,

Iwanaga²,

Loukas³

et al. 2018

Cureus

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Endometriosis is a gynecological disorder identified by the presence of ectopic endometrial tissue outside the uterus. Largely, it affects reproductive-aged women and is a major cause of infertility. Clinical manifestations of endometriosis include dyspareunia, cyclic menstrual pain, chronic pelvic pain, and dyschezia, all of which can affect the patient’s quality of life and health severely; therefore, it is paramount that medical treatment is initiated as soon as endometriosis is suspected clinically. In this review, we examine the known anatomic principles of endometriosis in the literature and outline ways to manage patients with this condition better.

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Section: Reviewmentioning

confidence: 99%

The Clinical Anatomy of Endometriosis: A Review

Alimi¹,

Iwanaga²,

Loukas³

et al. 2018

Cureus

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“…These were potential interesting findings since they highlighted the differences in the female and male reproductive system development. According to biological evidence, females are considered the ‘fundamental sex’, in which without chemical prompting, all fertilized eggs would develop into females [43]. Gonadal differentiation occurs before the end of the embryonic period, approximately the 7th week of gestation; both the reproductive ducts, external genitalia and sex differentiates occur around the 10th week of gestation [43].…”

Section: Discussionmentioning

confidence: 99%

Dietary exposures, epigenetics and pubertal tempo

Sánchez

Goodrich

et al. 2019

Environmental Epigenetics

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Gene expression changes mediated by DNA methylation may play a role in pubertal tempo regulation, and availability of methyl donor nutrients affects these pathways. We examined first trimester maternal and adolescent diet patterns that may be associated with DNA methylation at long interspersed nucleotide (LINE-1) repetitive elements in adolescence using least absolute shrinkage and selection operator (LASSO) and calculated an ‘Epigenetics-Associated Diet Score’ (EADS) for each pattern; then tested the associations of these scores with pubertal tempo among adolescent boys and girls. The analytic sample included 118 boys and 132 girls aged 10–18 years. DNA methylation at LINE-1 repetitive elements was quantified. Typical maternal and adolescent nutrient intakes were estimated using food frequency questionnaires. Interval-censored time to event and ordinal regression models were used to examine associations EADS scores with pubertal tempo using physician-assessed Tanner stages and self-reported menarche, respectively, adjusted for confounders. We observed associations between maternal EADS and pubertal onset, but not pubertal progression. Each standard deviation (SD) greater maternal EADS was associated with 52% higher odds of having later onset of menarche in both cross-sectional and prospective analysis ( P = 0.031 and 0.028, respectively). In contrast, we observed associations between adolescent EADS and pubertal progression, but not pubertal onset. Among boys, for each SD higher adolescent EADS, there was 13% increase in odds of slower genital progression ( P = 0.050), as well as 26 and 27% increase in odds of slower left and right testicular development, respectively ( P = 0.001). Epigenetic-associated diet influences pubertal tempo in a sex- and timing-specific manner.

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“…Incomplete or non-existent merging will result in two uteruses. Renal agenesis usually follows the Mullerian ducts dysgenesis because kidneys, fallopian tubes, cervix and proximal vagina are derived from the same ureteritic buds [ 7 ]. The reported variations are 72.4% with classical variants of uterus didelphys and 27.6% rare variants with uterus septum or cervical agenesis [ 8 ].…”

Section: Discussionmentioning

confidence: 99%