Embryological Characteristics and Clinical Outcomes of Oocytes with Heterogeneous Zona Pellucida During Assisted Reproduction Treatment: A Retrospective Study

Pan, Chengshuang; Zhang, Huan

doi:10.12659/msm.924316

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…The rates of clinical pregnancy, implantation, and live birth in the IZP group were signi cantly lower than those in the NZP groups, diverging from previous reports. [26,27]. signi cant improvement in clinical outcomes was observed with assisted hatching.…”

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confidence: 98%

The Embryological Characteristics and Clinical Outcomes of Oocytes with Indented Zona Pellucida

Lin,

Fang,

Yao

et al. 2024

Preprint

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Purpose The aim of this study is to investigate the embryological characteristics and clinical outcomes of oocytes with indented zona pellucida (ZP). Methods A total of 109 in vitro fertilization (IVF) cycles from 56 subjects had all oocytes with an indented ZP (IZP). Another 1095 cycles of 574 subjects with oocytes retrieved on the same time were included as controls (NZP). The comparisons were conducted between two groups in embryological characteristics and clinical outcomes. Results The patients with IZP suffered from significantly prolonged duration of infertility and were more likely to have primary infertility. In embryonic development, oocytes with IZP demonstrated significantly lower rates of oocyte retrieved, oocyte maturity, normal fertilization, embryo cleavage and embryo utilization. Thirty-two patients with IZP participated in the fresh embryo transfer, with a clinical pregnancy rate of 43.8% and a live birth rate of 34.4%, which were significantly lower than NZP group. In addition, the clinical outcomes of frozen embryo transfer (FET) cycles showed no significant differences. Compared to the rescue- intracytoplasmic sperm injection (ICSI) group, ICSI regimen facilitated a substantially higher rates of oocyte fertilization, cleavage, and enhanced efficiency in embryo utilization. Conclusions Patients with IZP had unsatisfactory embryological and fresh embryo transfer outcomes, and it was a favor choice to use ICSI insemination timely. FET might potentially mitigate the impact of ZP abnormalities.

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confidence: 98%

The Embryological Characteristics and Clinical Outcomes of Oocytes with Indented Zona Pellucida

Lin,

Fang,

Yao

et al. 2024

Preprint

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Embryological characteristics and clinical outcomes of oocytes with different degrees of abnormal zona pellucida during assisted reproductive treatment

Fang,

Sun,

Chen

et al. 2023

Zygote

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Abnormalities in the zona pellucida (ZP) adversely affect oocyte maturation, embryo development and pregnancy outcomes. However, the assessment of severity is challenging. To evaluate the effects of different degrees of ZP abnormalities on embryo development and clinical outcomes, in total, 590 retrieval cycles were scored and divided into four categories (control, mild, moderate and severe) based on three parameters: perivitelline space, percentage of immature oocytes and percentage of oocytes with abnormal morphology. As the severity of abnormal ZP increased, both the number of retrieved oocytes and mature oocytes decreased. The fertilization rate did not differ significantly among groups. The rates of embryo cleavage and day-3 high-quality embryos in the mild group and the moderate group did not vary significantly between the two groups but were significantly higher than those in the severe group. The blastulation rates of the abnormal ZP groups were similar; however, they were lower than those of the control group. Moreover, the cycle cancellation rate of the severe abnormal ZP group was as high as 66.20%, which was significantly higher than that of the other three groups. Although the rates of cumulative clinical pregnancy and live births were lower than those in the control group, they were comparable among the abnormal ZP groups. There were no differences in the neonatal outcomes of the different groups. Together, ZP abnormalities show various degrees of severity, and in all patients regardless of the degree of ZP abnormalities who achieve available embryos, there will be an opportunity to eventually give birth.

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Embryological Characteristics and Clinical Outcomes of Oocytes with Heterogeneous Zona Pellucida During Assisted Reproduction Treatment: A Retrospective Study

Cited by 2 publications

References 28 publications

The Embryological Characteristics and Clinical Outcomes of Oocytes with Indented Zona Pellucida

The Embryological Characteristics and Clinical Outcomes of Oocytes with Indented Zona Pellucida

Embryological characteristics and clinical outcomes of oocytes with different degrees of abnormal zona pellucida during assisted reproductive treatment

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