Embryo transfer under ultrasound guidance improves pregnancy rates after in-vitro fertilization

Coroleu, Buenaventura; Carreras, Olga; Veiga, Anna; Martell, Alfredo; Martínez, Francisca; Belil, I.; Hereter, L.; Barri, P.N.

doi:10.1093/humrep/15.3.616

Cited by 163 publications

(99 citation statements)

References 25 publications

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“…The importance of this step has been emphasized by the fact that different providers at the same institution may have disparate pregnancy rates after ET (8,9). Other variables affecting pregnancy include the ease of ET (7,10,11), presence or absence of blood on the transfer catheter (12), type of catheter used (13), technique used to perform the transfer (14)(15)(16), and experience of the physician (17).…”

mentioning

confidence: 99%

Embryo afterloading: A refinement in embryo transfer technique that may increase clinical pregnancy

Neithardt

Segars

Hennessy

et al. 2005

Fertility and Sterility

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Objective-Given the importance of ET technique during assisted reproductive technology cycles, we evaluated the effect of embryo afterloading subsequent to placement of the ET catheter on pregnancy rates vs. a standard direct ET. Design-Retrospective cohort analysis. Setting-University-based assisted reproductive technology program.Patient(s)-Patients undergoing a fresh nondonor day 3 ET by a single provider over a 1-year period. Intervention(s)-None. Main Outcome Measure(s)-Clinical pregnancy.Result(s)-One hundred twenty-seven patients met inclusion criteria, and the overall pregnancy rate was 46.5%. There was no difference between the two groups with respect to age, basal FSH, or number of embryos transferred. The ET method used was at the discretion of the provider. There was no difference between the two groups in the presence of blood on the transfer catheter. However, there were significantly more transfer catheters with mucus contamination in the direct transfer group (25.58% vs. 5.95%). The clinical pregnancy rate in the group with ET using the afterloading technique was higher than in the direct ET group (52.4% vs. 34.9%). Conclusion(s)-There was a trend toward an increase in pregnancy rate when an embryo afterloading technique was used. A prospective randomized trial is needed to examine this issue. Technology reported an increase in live birth rates from 28% in 1996 to 32% in 2002 (1). This increase has been attributed to multiple factors including improved stimulation protocols (2-4), advances in embryology laboratory techniques (5), and improvement in ET techniques (6, 7). KeywordsEmbryo transfer is universally accepted as a crucial last step in any ART cycle. The importance of this step has been emphasized by the fact that different providers at the same institution may have disparate pregnancy rates after ET (8,9). Other variables affecting pregnancy include the ease of ET (7, 10, 11), presence or absence of blood on the transfer catheter (12), type of catheter used (13), technique used to perform the transfer (14-16), and experience of the physician (17).In the early 1990s, studies were first published on the use of a mock or "dummy" ET before the start of an IVF cycle (11,18). A mock ET allows the physician to choose the appropriate transfer catheter, measure the depth of the endometrial cavity, and anticipate potential problems at ET. However, a mock transfer remote from the actual ET is done under different circumstances and may not be reflective of actual conditions encountered on the day of ET. Sharif et al. (19) proposed to circumvent this problem by performing a mock ET immediately before the actual ET.To avoid additional trauma by the passage of two separate catheters, we began transferring embryos by an afterload technique, in which an empty catheter is placed at, or just past, the internal cervical os. The inner sheath is withdrawn, and a second inner sheath containing the embryos is passed. This gives the provider the benefit of an immediate mock transfer while minimizing mani...

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confidence: 99%

Embryo afterloading: A refinement in embryo transfer technique that may increase clinical pregnancy

Neithardt

Segars

Hennessy

et al. 2005

Fertility and Sterility

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“…Recently, ultrasound-guided embryo transfer has been reported to improve the clinical pregnancy rate after IVF. For example, the clinical pregnancy rate among those undergoing embryo transfer with ultrasound guidance has been reported in the range of 38.4-50%, considerably higher than the 25.4-33.7%, reported for those embryo transfer was not assisted by ultrasound (4)(5)(6)(7)(8). Conversely, one study did not show any statistical difference in the pregnancy rate between the ultrasound-guided group (26.0%) and the nonultrasound-guided group (22.5%) (9).…”

Section: Introductionmentioning

confidence: 81%

Abdominal Ultrasound-Guided Embryo Transfer Improves Clinical Pregnancy Rates After In Vitro Fertilization: Experiences from 330 Clinical Investigations

Lü

Hao

et al. 2005

J Assist Reprod Genet

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Purpose : To investigate the effect of ultrasound-guided embryo transfer on the rate of implantation and clinical pregnancy. Methods : A prospective randomized trial was performed to compare ultrasound-guided embryo transfer with the traditional method. A total of 330 patients were randomly divided into two groups on the day of embryo transfer. For the cases (n = 178), ultrasound-guided was used; controls (n = 152) was performed using routine methods. Results : The rate of implantation and clinical pregnancy for the cases (19.6 and 37.1%, respectively) was significantly higher than for the controls (12.6 and 25%, respectively; p < 0.05). Conclusion : Ultrasound-guided embryo transfer can significantly increase the rate of implantation and clinical pregnancy, and should be recommended as a routine procedure in the process of in vitro fertilization and embryo transfer (IVF-ET).

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“…Several studies have recently analyzed variables affecting successful ET such as US-guided ET, mock transfer, type of catheter, loading the catheter, blood or mucus effects, retained embryos, uterine contractions, and facility of the procedure. Studies which evaluated the effect of US-guided ET indicated that US-guided ET appears to improve IVF success and is significantly associated with increased PRs [5][6][7][8]. However, during US-guided ET the ultrasonographic visualization of newer ET catheters and air bubbles, an identifier of the position of the embryos, is one of the most important developments regarding ET technique.…”

Section: Discussionmentioning

confidence: 99%

“…A targeted successful ET prevents endometrial injury and the induction of uterine contractions; it protects embryos and places embryos in an optimal position within the uterine cavity, thus maximizing embryo implantation. Ultrasound (US)-guided ET can overcome adverse effects including endometrial injury and the induction of uterine contractions during ET and it can determine ET depth and the location of air bubbles [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Can the Movement of the Air Bubbles After Embryo Transfer Predict the Success of IVF Treatment?

Özcan¹

2016

Ann Clin Anal Med

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Embryo transfer under ultrasound guidance improves pregnancy rates after in-vitro fertilization

Cited by 163 publications

References 25 publications

Embryo afterloading: A refinement in embryo transfer technique that may increase clinical pregnancy

Embryo afterloading: A refinement in embryo transfer technique that may increase clinical pregnancy

Abdominal Ultrasound-Guided Embryo Transfer Improves Clinical Pregnancy Rates After In Vitro Fertilization: Experiences from 330 Clinical Investigations

Can the Movement of the Air Bubbles After Embryo Transfer Predict the Success of IVF Treatment?

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