Embryo morphology and development are dependent on the chromosomal complement

Magli, M.C.; Gianaroli, Luca; Ferraretti, Anna Pia; Lappi, Michela; Ruberti, Alessandra; Farfalli, Valeria

doi:10.1016/j.fertnstert.2006.07.1512

Cited by 243 publications

(164 citation statements)

References 40 publications

(47 reference statements)

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“…Viewed from the opposite side, about 80 % of the embryos were aneuploidy. Still, the study by Magi et al also indicated that the incidence of chromosomal abnormalities was significantly lower at the 7-8 cell stage compared to all other stages [23]. In this present study, only morphologically good embryos, which developed to at least the 7-cell stage with less than 10 % fragmentation within 72 h after either insemination or ICSI, were used for the embryo transfer.…”

Section: Discussionmentioning

confidence: 57%

“…One possible explanation for implantation failure is that embryos carrying chromosomal abnormalities might be included in the morphologically optimal embryo groups. Indeed, according to one study, 20.9 % of cleavage stage embryos which derived from patients who were more than 36 years of age and had a history of multiple implantation failures showed euploidy according to the results of pre-implantation genetic diagnosis (PGD) [23]. Viewed from the opposite side, about 80 % of the embryos were aneuploidy.…”

Section: Discussionmentioning

confidence: 99%

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Hyaluronan-enriched transfer medium improves outcome in patients with multiple embryo transfer failures

Nakagawa¹,

Takahashi²,

Nishi³

et al. 2012

J Assist Reprod Genet

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Purpose To ascertain whether the use of hyaluronanenriched transfer medium (HETM) improves pregnancy and implantation rates among embryo transfer patients with a history of multiple implantation failures. Methods Patients (n0314) under the age of 40 and with a history of multiple unsuccessful embryo transfers were enrolled. There were three groups of patients: those undergoing fresh embryo transfer (fresh ET [n 0111]), those undergoing vitrified-warmed ET in the natural cycle (WET-N [n0101]) and those undergoing WET in a hormone replacement cycle ). On the day of ET, patients were randomized to HETM (0.5 mg/ml hyaluronan) or control medium containing no hyaluronan. Only patients with good quality embryos on day 3 were included. Results For all three patients groups (fresh ET, WET-N and WET-H) pregnancy rates (37.5 %, 31.4 % and 41.2 %, respectively) were significantly higher when using HETM compared with control medium (10.9 %, 10.0 % and 15.7 %, respectively; p<0.05), and implantation rates when using HETM were also significantly higher compared with control medium (p<0.05). Miscarriage rates were similar in both groups. Conclusion HETM significantly increased pregnancy and implantation rates among embryo transfer patients with a history of multiple unsuccessful implantations-regardless of method used to prepare the endometrium.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Hyaluronan-enriched transfer medium improves outcome in patients with multiple embryo transfer failures

Nakagawa¹,

Takahashi²,

Nishi³

et al. 2012

J Assist Reprod Genet

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“…6 Aneuploidy is the most common abnormality found in embryos derived from in-vitro fertilisation (IVF), and leads to poor outcomes. [7][8][9][10][11][12][13] Morphological assessment of embryos or blastocysts alone, however, cannot negate the potential risk of replacing aneuploid embryos or blastocysts. 14 Preimplantation genetic screening (PGS) has been proposed to improve the IVF outcomes by screening for aneuploid embryos or blastocysts.…”

Section: Discussionmentioning

confidence: 99%

Preimplantation genetic diagnosis and screening by array comparative genomic hybridisation: experience of more than 100 cases in a single centre

et al. 2017

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“…Moreover, arrested zygotes and slow cleaving embryos (two cells on day 2 or 3) are associated with higher rates of chromosomal abnormalities [22].…”

Section: Introductionmentioning

confidence: 99%

Is the presence of a non-cleaved embryo on day 3 associated with poorer quality of the remaining embryos in the cohort?

Machtinger

Bormann

Ginsburg

et al. 2015

J Assist Reprod Genet

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Purpose Morphological evaluation is currently considered the single most important predictive measure for assessing embryo quality. The aim of this study was to investigate whether cycles with at least one non-cleaved embryo (i.e., a 1-cell embryo on day 3) have different outcomes compared with cycles in which all embryos had cleaved by day 3. Methods All autologous IVF/ICSI cycles with a fresh day 3 transfer and without using a gestational carrier performed at our center between 1/1/2010 and 12/31/2011 were analyzed retrospectively. Those cycles with at least one non-cleaved embryo on day 3 were compared with all other autologous cycles that had l00 % cleaved embryos performed during the study period. Results Eight hundred and forty two cycles were included. Of them, 144 cycles comprised the non-cleaved group, and 698 cycles comprised the cleaved group. Cycles in the non-cleaved group had more oocytes retrieved (15.4±7.1 vs. 12.5±7.1, p<0.001), more zygotes obtained (10.0±5.3 vs. 7.9±5.2, p= <0.001), but the embryos exhibited lower cleavage rates and higher rates of fragmentation and asymmetry compared with controls (p<0.001). However, spontaneous abortion rates, ectopic pregnancies rates as well as delivery rates were similar between the two groups.Conclusions Our results show that the presence of a noncleaved embryo on day 3 is associated with a more exuberant response to controlled ovarian stimulation as reflected by more oocytes retrieved. Despite the significant decrease in quality of the whole cohort in the non-cleaved group, implantation, delivery rates and number of embryos frozen were not adversely affected by the presence of a non-cleaved embryo.

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Embryo morphology and development are dependent on the chromosomal complement

Cited by 243 publications

References 40 publications

Hyaluronan-enriched transfer medium improves outcome in patients with multiple embryo transfer failures

Hyaluronan-enriched transfer medium improves outcome in patients with multiple embryo transfer failures

Preimplantation genetic diagnosis and screening by array comparative genomic hybridisation: experience of more than 100 cases in a single centre

Is the presence of a non-cleaved embryo on day 3 associated with poorer quality of the remaining embryos in the cohort?

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