2021
DOI: 10.1056/nejmms2031080
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Embracing Genetic Diversity to Improve Black Health

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Cited by 84 publications
(66 citation statements)
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“… 8 , 9 , 10 However, genetic ancestry data are not yet readily available for clinical practice or for use in clinical studies, nor have that data been historically captured. 11 The historical static groupings of individuals by race and ethnicity with regards to reported health data over time have led to the acceptance and use of these categories in biomedical research. 7 Stratification by various racial and ethnic groupings has identified several important differences in disease risk as well as response to certain treatments.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“… 8 , 9 , 10 However, genetic ancestry data are not yet readily available for clinical practice or for use in clinical studies, nor have that data been historically captured. 11 The historical static groupings of individuals by race and ethnicity with regards to reported health data over time have led to the acceptance and use of these categories in biomedical research. 7 Stratification by various racial and ethnic groupings has identified several important differences in disease risk as well as response to certain treatments.…”
Section: Introductionmentioning
confidence: 99%
“… 7 Stratification by various racial and ethnic groupings has identified several important differences in disease risk as well as response to certain treatments. 11 In addition, the historical use of race and ethnicity as currently defined to differentiate patients in the study of disease has led to the emergence and recognition of medically underserved and underrepresented minority populations. 12 Thus, although imperfect, understanding disparities by racial and ethnic groupings is of value, particularly pertaining to the study of precision medicine, as it is important to understand from which populations we are collecting our biologic and biomarker data for use in the general cancer population.…”
Section: Introductionmentioning
confidence: 99%
“…However, none of the studies we examined performed genotyping or other computational methods to infer the study participants' genetic ancestry information. The use of the self-reported ancestry or race/ethnicity in TCR-seq studies may be considered to be reasonable at the current stage 11 . Second, the unified protocol of reporting study participants' REA information may introduce bias in our analysis.…”
Section: Discussionmentioning
confidence: 99%
“…Global human genetic diversity, including variation in clinically important pharmacogenes, has been shown to contribute to differential pharmacotherapeutic effects 9,10 . The full characterization of this worldwide diversity and its association with drug response phenotypes is important to all populations.…”
Section: Global Outreachmentioning
confidence: 99%