Embolization therapy for benign prostatic hyperplasia: Influence of embolization particle size on gland perfusion

Brook, Olga R.; Faintuch, Salomão; Brook, Alexander; Goldberg, S. Nahum; Rofsky, Neil M.; Lenkinski, Robert E.

doi:10.1002/jmri.23981

Cited by 35 publications

(23 citation statements)

References 31 publications

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“…In our previous studies with PAE in a DeKlerk’s model, various sizes of intraprostatic cavities were observed in all beagles 1 month after embolization (31); whereas it rarely occurred and was observed in only one out of eleven patients with BPH after prostatic artery embolization (41). Interestingly, our findings were inconsistent with a similar animal experiment by Brook et al (42). In this study, 12 old male intact beagles with a mean age of 6.9±1.4 years underwent PAE with the same embolic agents of various particle sizes.…”

Section: Hormone-induced Bph Modelscontrasting

confidence: 99%

Canine prostate models in preclinical studies of minimally invasive interventions: part II, benign prostatic hyperplasia models

Sun

Báez-Díaz

Sánchez‐Margallo

2017

Transl. Androl. Urol.

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Canine prostate is widely used as animal model in the preclinical evaluation of emerging therapeutic interventions. Spontaneous benign prostatic hyperplasia (BPH) is common in adult intact male dogs with two distinct pathological types: glandular and complex form of prostatic hyperplasia. The complex form of prostatic hyperplasia, usually occurring in older dogs, represents an ideal model because of its unique pathologic feature, including not only glandular hyperplasia but also an increase in prostate stromal components. The limited commercial availability of adult dogs with spontaneous BPH motivates experimentally induced BPH in young dogs. Hormone-induced canine BPH model has been well established with various hormonal treatment regimens and administration approaches. The goal of this review is to provide the veterinary background in spontaneous BPH in dogs, summarize the techniques in hormonal induction of canine BPH, and highlight the pathological and clinical limitations of the canine models that may lead to distinct therapeutic responses compared to clinical trials in humans.

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Section: Hormone-induced Bph Modelscontrasting

confidence: 99%

Canine prostate models in preclinical studies of minimally invasive interventions: part II, benign prostatic hyperplasia models

Sun

Báez-Díaz

Sánchez‐Margallo

2017

Transl. Androl. Urol.

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“…Although Jeon et al [10] suggested that smaller PVA particles may elicit better effects in PAE with further penetration into the periphery, there are concerns about nontarget embolization because of anastomoses between the prostatic arteries and neighboring arteries [25]. Furthermore, Brook et al [26] took another view that larger embolic particles may induce greater prostatic volume reductions and better results after PAE in a canine model. They considered 500–700 μ m microspheres as reasonable particle sizes for PAE in canine BPH.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Nonspherical Polyvinyl Alcohol Particles and Microspheres for Prostatic Arterial Embolization in Patients with Benign Prostatic Hyperplasia

Hwang

Park

Chang³

et al. 2017

BioMed Research International

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Purpose To report early results following prostatic artery embolization (PAE) and compare outcomes between nonspherical polyvinyl alcohol (PVA) particles and microspheres to treat lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). Methods PAE was performed in nine patients (mean age: 78.1 years) with symptomatic BPH. Embolization was performed using nonspherical PVA particles (250–355 μm) in four patients and microspheres (300–500 μm) in five patients. Results PAE was technically successful in all nine patients (100%). During a mean follow-up of 10.1 months, improvements in mean International Prostate Symptom Score (IPSS), Quality of Life (QoL), prostatic volume (total volume and transition zone), and peak urinary flow (Qmax) were 9.8 points, 2.3 points, 28.1 mL, 17.8 mL, and 4.5 mL/s, respectively. Clinical success was obtained in seven of nine patients (78%). Patients in the microsphere group showed greater improvement in IPSS, QoL, prostatic volume, and Qmax compared to patients in the nonspherical PVA particle group. However, significant difference was noted only in the prostatic volume. Conclusion PAE is a feasible, effective, and safe treatment option for BPH with LUTS. Use of microspheres showed greater prostatic volume reduction compared to nonspherical PVA particles.

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“…8,14 In analysing preembolisation MRI studies, many differences among prostates, in addition to their size, shape, or symmetry, have been described. 15,16 On T2-weighted MRI, different patterns of signal intensity can be observed, and these are certainly related to prostate tissue composition.…”

Section: Discussionmentioning

confidence: 99%

MRI assessment of prostatic ischaemia: best predictor of clinical success after prostatic artery embolisation for benign prostatic hyperplasia

Kisilevzky¹,

Faintuch

2016

Clinical Radiology

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Embolization therapy for benign prostatic hyperplasia: Influence of embolization particle size on gland perfusion

Abstract: The enhancement and morphological data are useful to monitor response to therapy after embolization. Embolization with 300-500 and 500-700 μm particle may provide better results than with 100-300 μm particles in a canine model.

Cited by 35 publications

References 31 publications

Canine prostate models in preclinical studies of minimally invasive interventions: part II, benign prostatic hyperplasia models

Canine prostate models in preclinical studies of minimally invasive interventions: part II, benign prostatic hyperplasia models

Comparison of Nonspherical Polyvinyl Alcohol Particles and Microspheres for Prostatic Arterial Embolization in Patients with Benign Prostatic Hyperplasia

MRI assessment of prostatic ischaemia: best predictor of clinical success after prostatic artery embolisation for benign prostatic hyperplasia

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