Esophageal perforations may recur, and/or develop a mature fistulous tract to the pleura, despite prompt surgical management. Treatment of a chronic esophageal fistula is challenging and may require multiple reoperations. We describe the closure of a controlled, chronic, benign esophagopleural fistula using an Amplatzer occluder and sealed with a liquid copolymer after failed open repair. At 3 years postprocedure, the patient has no further recurrence or complication associated with the repair. Amplatzer plugs and occluders, designed for endovascular and cardiac procedures, are increasingly used off-label for the treatment of complex, recurrent, or otherwise difficult to manage bronchopulmonary, pleural, and esophageal fistulae.The patient is a 59-year-old woman, current smoker, otherwise healthy, who presented to an outside institution 1 year prior with a spontaneous esophageal perforation. Athough she did have a remote history of alcohol abuse, she denied any recent emesis or retching. She presented several days after the onset of symptoms, and consequently primary repair of the perforation was not attempted. The perforation was accessed via a right thoracotomy, treated with wide drainage, and healed over the subsequent 2 months with nutritional support and a prolonged hospital course.Four months later, she presented with recurrent fever and chest pain. A barium esophagogram demonstrated extravasation of contrast into the right pleural space (Figure 1). Again, right thoracotomy was performed, and primary repair of the perforation was undertaken. However, the fistula recurred and failed to close over the following weeks, despite adequate drainage and nutritional support with jejunal tube feeding.The patient was subsequently transferred to our institution for further management. Given that the fistula was chronic and failed to close after attempted primary repair and prolonged drainage, we elected to place a self-expanding, fully covered metal stent (23 Â 105 mm WallFlex; Boston Scientific, Natick, Massachusetts; Figure 2). However, the stent migrated into the stomach, despite securing the stent to the mucosa with clips. Of note, there was neither a stricture nor a mass distal to the perforation, upper endoscopic examination was otherwise normal to the duodenum, and there was no appreciable obstruction or holdup of contrast during barium esophagogram.Consequently, we elected to attempt closure of the esophagopleural fistula with an Amplatzer endovascular ventricular septal defect (VSD) occluder (St Jude Medical, St Paul, Minnesota). This procedure was performed under general anesthesia in the operating room. Under endoscopic