Embolization of Cerebral Arteriovenous Malformations with Bucrylate

Berthelsen, Birgitte; Löfgren, Jan; Svendsen, P.

doi:10.1177/028418519003100103

Cited by 38 publications

(5 citation statements)

References 23 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tissue adhesive is a very useful agent for various surgeries, such as skin closure in wound care,1 brain vascular anastomosis in brain surgery,2 aorta vascular anastomosis,3 as well as bone piece adhesive in osteosurgery. Varied requirements cause that a single adhesive could not meet so many needs.…”

Section: Introductionmentioning

confidence: 99%

A tissue adhesives evaluated in vitro and in vivo analysis

Mo¹,

Iwata²,

Ikada³

2010

J Biomedical Materials Res

View full text Add to dashboard Cite

In this study, three kinds of two-component adhesive glues were prepared, namely, gel-dext glue made from modified gelatin and dextran, gel-HES glue made from modified gelatin and hydroxyethyl starch (HES), and chit-dext glue made from chitosan and modified dextran. Upon mixing the two-component solution together crosslinking occurred and a gel formed in several seconds, which would seal the wound tissue and stop the bleeding. The adhesive ability of those three prepared glues was evaluated in vitro and in vivo separately by measuring the bonding strength to two piece of porcine skin and the adhesive strength after sealing the skin incisions on the back of rat. Fibrin glue was used as comparing. Gel-dext glue and gel-HES glue shown higher bonding strength and adhesive strength than chit-dext glue and fibrin glue. Histology test of incision tissues given by both HE and MTC methods, the former shown that gel-dext and gel-HES glues, like fibrin glue, have only normal initial inflammation to skin tissue, which almost disappear from 9 days but chit-dext glue seams have heaver inflammation, which may last to 12 days; the later shown gel-dext and gel-HES glues similar to fibrin glue, can heal the wound fast than that of chit-dext glue. The hemostatic ability for gel-HES glue was also tested on a cut liver of rat, which depend on the gel formation speed when the two-composite solutions were mixed together. (c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.

show abstract

Section: Introductionmentioning

confidence: 99%

A tissue adhesives evaluated in vitro and in vivo analysis

Mo¹,

Iwata²,

Ikada³

2010

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…Therefore embolization has been used mainly to reduce the size of the AVM before surgery, although the association of embolization and radiosurgery has seldom been reported. 1,4,[11][12][13]17,23,33,36,40,47 Embolizing a large AVM before applying radiosurgery has three theoretical advantages: 1) it can reduce the size of the AVM so that the residual nidus can be irradiated with a better cure rate and fewer side effects; 2) it can occlude associated arterial or intranidal aneurysms to reduce the risk of bleeding while awaiting the delayed action of radiosurgery and AVM thrombosis; and 3) it can target large arteriovenous fistulas (AVFs) associated with a plexiform AVM. Such AVFs, because the mechanism of action of radiosurgery is endothelial proliferation and thrombosis, are in our opinion less sensitive to radiosurgery.…”

mentioning

confidence: 99%

Treatment of brain arteriovenous malformations by embolization and radiosurgery

Gobin¹,

Laurent²,

Merienne³

et al. 1996

Journal of Neurosurgery

370

145

View full text Add to dashboard Cite

Embolization was used to reduce the size of brain arteriovenous malformations (AVMs) prior to radiosurgical treatment in 125 patients who were poor surgical candidates or had refused surgery. Of these patients, 81% had suffered hemorrhage, and 22.4% had undergone treatment at another institution. According to the Spetzler-Martin scale, the AVMs were Grade II in 9.6%, Grade III in 31.2%, Grade IV in 30.4%, and Grades V to VI in 28.8% of the cases. Most embolizations were performed using cyanoacrylate delivered by flow-guided microcatheters. Radiosurgery was performed using a linear accelerator in 62 patients treated by the authors, and 34 patients were treated at other institutions using various methods. Embolization produced total occlusion in 11.2% of AVMs and reduced 76% of AVMs enough to allow radiosurgery. Radiosurgery produced total occlusion in 65% of the partially embolized AVMs (79% when the residual nidus was < 2 cm in diameter). Embolizations resulted in a mortality rate of 1.6% and a morbidity rate of 12.8%. No complications were associated with radiosurgery. The hemorrhage rate for partially embolized AVMs was 3% per year. No patient with a completely occluded AVM experienced rehemorrhage. Angiographic follow-up review of AVMs embolized with cyanoacrylate demonstrated a 11.8% revascularization rate, occurring within 1 year. It is concluded that after partial embolization with cyanoacrylate, the risk of hemorrhage from the residual nidus is comparable to the natural history of AVMs and that the residual nidus can be irradiated with results almost as good as for a native AVM of the same size.

show abstract

“…With regard to TN with dural fistula, the results of endovascular therapy are diverse: there are two reports with permanent success [6,13] and one case with recurrence of symptoms two months after successful endovascular treatment [8]. The possibility remains that a recurrence may occur after primary complete endovascular obliteration, probably due to vasospasm or thrombosis of supplying vessels with later recanalisation, as was reported in a series treating AVM [2] or dural fistula [5]. This explains why neurosurgeons still fear that glue embolisation of intracranial AVM cannot provide long-term occlusion of these lesions.…”

Section: Discussionmentioning

confidence: 97%

Endovascular Treatment of Trigeminal Neuralgia Caused by Arteriovenous Malformation: Is Surgery Really Necessary?

Wanke

Dietrich²,

Oppel³

et al. 2005

Zentralbl Neurochir

View full text Add to dashboard Cite

A case is presented with secondary trigeminal neuralgia (TN) caused by an arteriovenous malformation (AVM) of the cerebellopontine cistern, which was detected by radiological work-up for planned microvascular decompression. An AVM surrounding the trigeminal nerve was demonstrated on thin-slice heavily T (2)-weighted 3D-sequence on magnetic resonance imaging (MRI) and confirmed by angiography. The first therapeutic step was endovascular embolization with complete obliteration of the AVM and cessation of pain. Nevertheless surgical excision was performed in order to remove compressive vessels and to prevent a recurrence of pain.

show abstract

Embolization of Cerebral Arteriovenous Malformations with Bucrylate

Cited by 38 publications

References 23 publications

A tissue adhesives evaluated in vitro and in vivo analysis

A tissue adhesives evaluated in vitro and in vivo analysis

Treatment of brain arteriovenous malformations by embolization and radiosurgery

Endovascular Treatment of Trigeminal Neuralgia Caused by Arteriovenous Malformation: Is Surgery Really Necessary?

Contact Info

Product

Resources

About