Embolisation devices from biomedical polymers for intra-arterial occlusion and drug delivery in the treatment of cancer

Lewis, Andrew L.

doi:10.1533/9780857096760.3.207

Cited by 6 publications

(15 citation statements)

References 67 publications

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“…HepaSphere ™ microspheres are synthesized by a polymerization process of vinyl acetate and methyl acrylate monomers, forming superabsorbent beads that are distributed dry. These beads swell up to 64 times their dry volume following hydration [103,104]. Both of these beads have been tested and approved for loading and release of irinotecan or doxorubicin in TACE treatments in the liver.…”

Section: Commercially Available Materialsmentioning

confidence: 99%

Polymeric materials for embolic and chemoembolic applications

Poursaid

Jensen

Huo

et al. 2016

Journal of Controlled Release

113

103

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Percutaneous transcatheter embolization procedures involve the selective occlusion of blood vessels. Occlusive agents, referred to as embolics, vary in material characteristics including chemical composition, mechanical properties, and the ability to concurrently deliver drugs. Commercially available polymeric embolics range from gelatin foam to synthetic polymers such as poly(vinyl alcohol). Current systems under investigation include tunable, bioresorbable microspheres composed of chitosan or poly(ethylene glycol) derivatives, in situ gelling liquid embolics with improved safety profiles, and radiopaque embolics that are trackable in vivo. This article reviews commercially available materials used for embolization as well as polymeric materials that are under investigation.

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Section: Commercially Available Materialsmentioning

confidence: 99%

Polymeric materials for embolic and chemoembolic applications

Poursaid

Jensen

Huo

et al. 2016

Journal of Controlled Release

113

103

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“…The main advantage of using polymers is that their properties can meet the intended requirements, such as biocompatibility, lubricity, drug delivery, and the ability to biodegrade. 36 Polymeric microspheres also have the advantage of producing welldefined physical parameters with desired size range, resulting in predictable and more manageable injecting. 7 Further, polymer-based microspheres could be fabricated with various characteristics, including compressibility, elasticity, and ri- Biocompatible, hydrophilic, non-immunogenic, ease of cell encapsulation, affordable, ease of availability, and feasible synthesis method chosen for drug delivery Slow degradation 41, 49…”

Section: Non-radioactive Microspheresmentioning

confidence: 99%

“…As used for TAE and TACE, embolic microspheres were developed by using a polymer as a basic material. The main advantage of using polymers is that their properties can meet the intended requirements, such as biocompatibility, lubricity, drug delivery, and the ability to biodegrade . Polymeric microspheres also have the advantage of producing well-defined physical parameters with desired size range, resulting in predictable and more manageable injecting .…”

Section: Non-radioactive Microspheresmentioning

confidence: 99%

“…This product is a sponge-like microsphere with a highly microporous structure . This product was developed as an embolization agent to overcome issues with particulate PVA in irregular shapes resulting in aggregation that caused more variable and proximal occlusions and increased the risk of nontarget embolization by small particles as seen in Figure . A clinical study for uterine fibroid embolization using PVA microspheres (Contour SE) showed comparable results to tris acryl gelatin (Embosphere) as an embolic agent .…”

Section: Non-radioactive Microspheresmentioning

confidence: 99%

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The Use of Microspheres for Cancer Embolization Therapy: Recent Advancements and Prospective

Nuzulia,

Mart,

Ahmed

et al. 2024

ACS Biomater. Sci. Eng.

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Embolization therapy involving biomaterials has improved the therapeutic strategy for most liver cancer treatments. Developing biomaterials as embolic agents has significantly improved patients' survival rates. Various embolic agents are present in liquid agents, foam, particulates, and particles. Some of the most applied embolic agents are microparticles, such as microspheres (3D micrometer-sized spherical particles). Microspheres with added functionalities are currently being developed for effective therapeutic embolization. Their excellent properties of high surface area and capacity for being loaded with radionuclides and alternate active or therapeutic agents provide an additional advantage to overcome limitations from traditional cancer treatments. Microspheres (nonradioactive and radioactive) have been widely used and explored for localized cancer treatment. Non-radioactive microspheres exhibit improved clinical performance as drug delivery vehicles in chemotherapy due to their controlled and sustained drug release to the target site. They offer better flow properties and are beneficial for the ease of delivery via injection procedures. In addition, radioactive microspheres have also been exploited for use as an embolic platform in internal radiotherapy as an alternative to cancer treatment. This short review summarizes the progressive development of non-radioactive and radioactive embolic microspheres, emphasizing material characteristics. The use of embolic microspheres for various modalities of therapeutic arterial embolization and their impact on therapeutic performance are also discussed.

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“…The basic chemical structure of the DC Bead is polyvinyl alcohol (PVA) hydrogel modified with sulfonate groups. Another commercially available microsphere is HepaSphere which is manufactured based on the polymerization of vinyl acetate and methyl acrylate monomers (Lewis, 2013). Clinical trials utilizing either DC Bead or HepaSphere microspheres in TACE for HCC showed favorable treatment effects with excellent tolerability (Brown et al, 2016; Deipolyi et al, 2015; Malagari et al, 2019).…”

Section: Microspheresmentioning

confidence: 99%

Recent advances and applications of microspheres and nanoparticles in transarterial chemoembolization for hepatocellular carcinoma

Valkenburgh

Chen

et al. 2021

WIREs Nanomed Nanobiotechnol

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Transarterial chemoembolization (TACE) is a recommended treatment for patients suffering from intermediate and advanced hepatocellular carcinoma (HCC). As compared to the conventional TACE, drug‐eluting bead TACE demonstrates several advantages in terms of survival, treatment response, and adverse effects. The selection of embolic agents is critical to the success of TACE. Many studies have been performed on the modification of the structure, size, homogeneity, biocompatibility, and biodegradability of embolic agents. Continuing efforts are focused on efficient loading of versatile chemotherapeutics, controlled sizes for sufficient occlusion, real‐time detection intra‐ and post‐procedure, and multimodality imaging‐guided precise treatment. Here, we summarize recent advances and applications of microspheres and nanoparticles in TACE for HCC. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

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Embolisation devices from biomedical polymers for intra-arterial occlusion and drug delivery in the treatment of cancer

Cited by 6 publications

References 67 publications

Polymeric materials for embolic and chemoembolic applications

Polymeric materials for embolic and chemoembolic applications

The Use of Microspheres for Cancer Embolization Therapy: Recent Advancements and Prospective

Recent advances and applications of microspheres and nanoparticles in transarterial chemoembolization for hepatocellular carcinoma

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