Embolic thrombus on mitral anulus calcification

Malaterre, H; Habib, Gilbert; Leude, E; Malmejac, C; Vaillant, A; Djiane, P

doi:10.1016/s0894-7317(96)90487-3

Cited by 10 publications

(13 citation statements)

References 5 publications

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“…The average age of our two patients, and the previously reported patients with renal failure and mobile elements, was 55 years old 8 , 11–13 . The average age of the ten patients with mobile components associated with MAC and normal renal function was 72 years old 5–7 , 9,10 . This age differential is consistent with the relationship of age to cardiovascular calcification in ESRD observed by others 23 …”

Section: Discussionsupporting

confidence: 89%

“…Less commonly, calcific or thrombotic emboli originating from the MAC directly cause CVA 4 . Mobile masses associated with MAC have recently been detected by echocardiography in patients with CVA and other systemic embolic events 5–13 . These recent observations support the hypothesis that emboli originating from the MAC are one of the causes of CVA in these patients.…”

mentioning

confidence: 63%

“…Although the precise composition and pathogenesis of these mobile components is unknown, other investigators have speculated that erosion of the endothelium overlying the MAC allows extrusion of calcium, which may then provide a nidus for thrombus formation 6 , 9 , 17 . The mobile components associated with MAC detected by echocardiography are most likely calcium or thrombus, and in previous reports both possibilities have been considered 5–11 , 13 . In the reports in which the masses were surgically excised, histologic examination revealed the masses to be predominantly calcium 5 , 8 , 11 .…”

Section: Discussionmentioning

confidence: 99%

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Mobile Components Associated With Rapidly Developing Mitral Annulus Calcification in Patients With Chronic Renal Failure: Review of Mobile Elements Associated With Mitral Annulus Calcification

et al. 2003

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Mitral annulus calcification may directly cause cerebrovascular accidents by serving as a source of calcific or thrombotic emboli. This hypothesis has been supported by recent reports of mobile components associated with mitral annulus calcification detected by echocardiography. Cardiovascular calcifications, including mitral annulus calcification, are common in end-stage renal disease and may develop and progress over a short period of time. We report two patients with mobile components associated with mitral annulus calcification and end-stage renal disease. Serial echocardiography documented that the mitral annulus calcification in these two patients had developed rapidly. Follow-up echocardiography in one patient demonstrated resolution of the mobile elements.

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Section: Discussionsupporting

confidence: 89%

mentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

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Mobile Components Associated With Rapidly Developing Mitral Annulus Calcification in Patients With Chronic Renal Failure: Review of Mobile Elements Associated With Mitral Annulus Calcification

et al. 2003

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“…However, hemodynamic problems and strokes are an indication for curative surgery or for preventing recurrence. The link between CMA and stroke was emphasized by Benjamin et al [7] and Malaterre et al [8], and this can be logically extrapolated to cover CCMA. In the Harpaz et al series [1], 26% of patients included had a prior history of cardiovascular events but with no established link to cardiac embolism.…”

Section: Discussionmentioning

confidence: 96%

Spontaneous fistulization of a caseous calcification of the mitral annulus: an exceptional cause of stroke

Chevalier¹,

Réant²,

Laffite³

et al. 2011

European Journal of Cardio-Thoracic Surgery

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We present the case of a caseous calcification of the mitral annulus, responsible for two strokes, in a 72-year-old female patient. The brain computed tomography (CT) scan confirmed the presence of a calcific embolus. The echocardiography showed a liquidy, pseudotumoral mass combined with numerous calcifications located in the posterior part of the mitral annulus and extending toward the inferior surface of the left ventricle. During surgery, we found a direct communication between the caseous necrosis and the lumen of the left ventricle at the level of its inferior wall. We performed a valve repair procedure and excision of the caseous necrosis, combined with injection of bioglue into the cavity, to avoid recurrence. Six months after the procedure, the patient was in good health, and had no recurrence of stroke with a satisfactory echocardiography. This is the first description of spontaneous fistulization of a caseous necrosis in the lumen of the left ventricle, explaining a new mechanism for cerebral embolism during the course of calcifying diseases of the mitral annulus.

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“…Several studies have demonstrated an association between mitral annular calcification and stroke [2, 3]. The mechanism for stroke is unclear.…”

Section: Discussionmentioning

confidence: 99%

Caseous Necrosis of Mitral Annulus: A Rare Cause of Stroke

Corré

Leroux

Coste

2013

Case Reports in Cardiology

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The current report describes a rare case of a caseous necrosis presenting as a pseudotumor in ventricle, revealed by stroke. Cerebral MRI, showing multiples lacunes, evocates a cardioembolic mechanism. Transthoracic and transesophageal echocardiography demonstrate a large hyperechogenic mass fixed to the posterior mitral valve and annulus while thoracic tomography revealed a fully calcified lesion, at the mitral annulus, evocative of caseus necrosis. Medical therapy was preferred (anticoagulation), because of her age and the decaying nature of surgery.

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Embolic thrombus on mitral anulus calcification

Cited by 10 publications

References 5 publications

Mobile Components Associated With Rapidly Developing Mitral Annulus Calcification in Patients With Chronic Renal Failure: Review of Mobile Elements Associated With Mitral Annulus Calcification

Mobile Components Associated With Rapidly Developing Mitral Annulus Calcification in Patients With Chronic Renal Failure: Review of Mobile Elements Associated With Mitral Annulus Calcification

Spontaneous fistulization of a caseous calcification of the mitral annulus: an exceptional cause of stroke

Caseous Necrosis of Mitral Annulus: A Rare Cause of Stroke

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