Embelin Attenuates Intracerebroventricular Streptozotocin-Induced Behavioral, Biochemical, and Neurochemical Abnormalities in Rats

Arora, Rimpi; Deshmukh, Rahul

doi:10.1007/s12035-016-0182-y

Cited by 38 publications

(36 citation statements)

References 45 publications

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“…Despite remarkable progress in understanding pathogenesis of dementia, the search for a cure against these diseases is troublesome and frustrating; for Decades now, complications of the AD have made the development of its therapeutic intervention quite a challenging task. 29 Although the currently prescribed molecules provide some improvement in the clinical condition of patients, it is at a cost of having to bear the burden of their adverse effects and lack of their curative effects. 37 Thus it is imperative to keep exploring different approaches that can be used to target the AD complications which could be translated into successful clinical trials.…”

Section: Discussionmentioning

confidence: 99%

“…Spatial learning and memory of animals in Morris water maze (MWM) was tested by the method described. 29…”

Section: Morris Water Maze Testmentioning

confidence: 99%

“…Catecholamines, dopamine, 5 hydroxytryptymine and norepinephrine (DA, 5-HT and NE) levels were estimated by HPLC using electrochemical detector according to the method described by Arora and Deshmukh. 29…”

Section: Estimation Of Catecholaminesmentioning

confidence: 99%

“…The estimation of GABA and glutamate was done by method described by Donzanti and Yamamoto 36 with slight modifications as described by Arora and Deshmukh. 29 The values are expressed as percentage of Normal Control group.…”

Section: Estimation Of Gaba and Glutamatementioning

confidence: 99%

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Chebulinic Acid Negated the Development of Streptozotocin- Induced Experimental Dementia in Rats

Rimpi

Deshmukh

2020

IJPI

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Background: With the constant failure of the clinical trials and continuous exploration of a therapeutic target against Alzheimer's disease (AD) is the utmost needed. Chebulinic acid (ChA) has been reported to possess neuroprotective potential in various neurodegenerative models such as anxiety and depression. Materials and Methods: In the current study, the ChA was challenged on the progression of AD induced by intracerebroventricular (ICV)-streptozotocin (STZ)-induced neurotoxicity to determine its therapeutic potential in experimental dementia. STZ was infused bilaterally (3 mg/kg/icv) on day 1 st and 3 rd after surgery. ChA (25, 50 and 100 mg/kg/p.o) was administered from 7 th day onwards up to 21 st day following 1 st ICV-STZ infusion. Cognitive impairment was evaluated by actophotometer, Morris water maze (MWM) and object recognition task (ORT) in rats whereas biochemical, neurochemical, neuroinflammatory were evaluated using hipoocampal brain regions on day 22 nd. Results: Ventricular administration of STZ in rats found to significantly shorten the latency time on the MWM and ORT which was associated with significant alterations in hippocampal biochemistry, including elevation in oxidative stress and compromised antioxidant defense, neurotransmitter alteration and elevation in neuroinflammatory cytokine levels. ChA treatment significantly prevented the ICV-STZ-induced memory deficit by attenuating the hippocampal neuronal loss, neuroinflammation and compromised antioxidant defense and cholinergic deficits in rats. Conclusion: These results clearly pointed to the pivotal role of ChA in ICV-STZ induced neurotoxicity and its association may be a promising alternative to be investigated in the treatment of AD-like dementia.

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Section: Discussionmentioning

confidence: 99%

“…Spatial learning and memory of animals in Morris water maze (MWM) was tested by the method described. 29…”

Section: Morris Water Maze Testmentioning

confidence: 99%

Section: Estimation Of Catecholaminesmentioning

confidence: 99%

Section: Estimation Of Gaba and Glutamatementioning

confidence: 99%

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Chebulinic Acid Negated the Development of Streptozotocin- Induced Experimental Dementia in Rats

Rimpi

Deshmukh

2020

IJPI

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“…This might be in line with timely different sensitivity of striatal D1 and D2 receptors on toxin treatment (Anitha et al 2012). Changes in DA transmission in the STZ-icv rat model seem to be region-specific and STZ-dose-and post-treatment-dependent; an increase in DA content was observed after 1 week in the whole brain only with doses > 5 mg/kg (Lacković and Šalković 1990) while after 3 weeks, a huge decrease in DA content was reported in the hippocampus with a dose of 3 mg/kg (Arora and Deshmukh 2017;Kaundal et al 2018) whereas at the same time point no change in DA content was seen in the striatum with a dose of 0.5 mg/kg (Ding et al 1992). Furthermore, the expression of DAT mRNA gradually decreases in the course of post STZ-icv treatment time (0.5 mg/kg) in the ventral medial bundle reaching the level of statistical significance 4 weeks after the treatment, while, during that time it remained unchanged in the arcuate nucleus (Salković-Petrisić and Lacković 2003).…”

Section: Indirect Toxicity Towards Dopaminergic Signallingmentioning

confidence: 99%

Shared cerebral metabolic pathology in non-transgenic animal models of Alzheimer's and Parkinson's disease

et al. 2020

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Parkinson's disease (PD) and Alzheimer's disease (AD) are the most common chronic neurodegenerative disorders, characterized by motoric dysfunction or cognitive decline in the early stage, respectively, but often by both symptoms in the advanced stage. Among underlying molecular pathologies that PD and AD patients have in common, more attention is recently paid to the central metabolic dysfunction presented as insulin resistant brain state (IRBS) and altered cerebral glucose metabolism, both also explored in animal models of these diseases. This review aims to compare IRBS and alterations in cerebral glucose metabolism in representative non-transgenic animal PD and AD models. The comparison is based on the selectivity of the neurotoxins which cause experimental PD and AD, towards the cellular membrane and intracellular molecular targets as well as towards the selective neurons/non-neuronal cells, and the particular brain regions. Mitochondrial damage and coexpression of insulin receptors, glucose transporter-2 and dopamine transporter on the membrane of particular neurons as well as astrocytes seem to be the key points which are further discussed in a context of alterations in insulin signalling in the brain and its interaction with dopaminergic transmission, particularly regarding the time frame of the experimental AD/ PD pathology appearance and the correlation with cognitive and motor symptoms. Such a perspective provides evidence on IRBS being a common underlying metabolic pathology and a contributor to neurodegenerative processes in representative non-transgenic animal PD and AD models, instead of being a direct cause of a particular neurodegenerative disorder.Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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Embelin: A novel XIAP inhibitor for the prevention and treatment of chronic diseases

Daimary

Girisa

Dey

et al. 2021

J Biochem & Molecular Tox

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Chronic diseases are a serious health concern worldwide, especially in the elderly population. Most chronic diseases like cancer, cardiovascular ailments, neurodegenerative disorders, and autoimmune diseases are caused due to the abnormal functioning of multiple signaling pathways that give rise to critical anomalies in the body. Although a lot of advanced therapies are available, these have failed to entirely cure the disease due to their less efficacy. Apart from this, they have been shown to manifest disturbing side effects which hamper the patient's quality of life to the extreme. Since the last few decades, extensive studies have been done on natural herbs due to their excellent medicinal benefits. Components present in natural herbs target multiple signaling pathways involved in diseases and therefore hold high potential in the prevention and treatment of various chronic diseases. Embelin, a benzoquinone, is one such agent isolated from Embelia ribes, which has shown excellent biological activities toward several chronic ailments by upregulating a number of antioxidant enzymes (e.g.

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Embelin Attenuates Intracerebroventricular Streptozotocin-Induced Behavioral, Biochemical, and Neurochemical Abnormalities in Rats

Cited by 38 publications

References 45 publications

Chebulinic Acid Negated the Development of Streptozotocin- Induced Experimental Dementia in Rats

Chebulinic Acid Negated the Development of Streptozotocin- Induced Experimental Dementia in Rats

Shared cerebral metabolic pathology in non-transgenic animal models of Alzheimer's and Parkinson's disease

Embelin: A novel XIAP inhibitor for the prevention and treatment of chronic diseases

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