Embedding magnesium metallic particles in polycaprolactone nanofiber mesh improves applicability for biomedical applications

Adhikari, Udhab; An, Xiaoxian; Rijal, Nava P.; Hopkins, Tracy; Khanal, Shalil; Chávez, Tom; Tatu, Rigwed; Sankar, Jagannathan; Little, Kevin J.; Hom, David B.; Bhattarai, Narayan; Pixley, Sarah K.

doi:10.1016/j.actbio.2019.04.061

Cited by 62 publications

(43 citation statements)

References 89 publications

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“…For some defined applications, organic or inorganic particles are added to polymer solutions [38], for example to improve the mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Investigation of metallic nanoparticle distribution in PAN/magnetic nanocomposites fabricated with needleless electrospinning technique

Trabelsi

Mamun

Klöcker

et al. 2021

cdatp

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Needleless electrospinning can be used to produce polyacrylonitrile nanofibres, for example, to which magnetic nanoparticles can additionally be added. Such composite nanofibres can then be stabilised and carbonised to produce carbon composite nanofibres. The magnetic nanoparticles have an influence not only on the structure but also on the mechanical and electrical properties of the finished carbon nanofibres, as does the heat treatment during stabilisation and incipient carbonisationThe present study reports on the fabrication, heat treatment and resulting properties of poly(acrylonitrile) (PAN)/magnetic nanofibre mats prepared by needleless electrospinning from polymer solutions. A variety of microscopic and thermal characterisation methods were used to investigate in detail the chemical and morphological transition during oxidative stabilisation (280 °C) and incipient carbonisation (500 °C). PAN and nanoparticles were analysed during all stages of heat treatment. Compared to pure PAN nanofibres, the PAN/ magnetic nanofibers showed larger fiber diameters and the presence of beads and agglomerations. In this study, magnetic nanofibers were investigated in more detail with the aim of detecting undesired agglomerations. Visual observation, for example with CLSM or SEM, does not provide conclusive evidence of agglomerations in the nanofibers. But based on the capabilities of SEM/EDS many different types of samples can be easily analysed where other analytical techniques simply cannot give the fast answer.

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“…For some defined applications, organic or inorganic particles are added to polymer solutions [38], for example to improve the mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Investigation of metallic nanoparticle distribution in PAN/magnetic nanocomposites fabricated with needleless electrospinning technique

Trabelsi

Mamun

Klöcker

et al. 2021

cdatp

View full text Add to dashboard Cite

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“…At the end of the ultrasound examination (30,60, or 90 days after the surgical procedure), the experimental animals were sacrificed under saturated CO 2 atmosphere.…”

Section: Methodsmentioning

confidence: 99%

“…A literature survey did not reveal studies devoted to the use of equine pericardium in the abdominal wall repair. Moreover, albeit the growing interest in the molecular analysis of abdominal wall reconstruction devices [28][29][30][31] , no standardised methods are still available for assessing in detail the biochemical changes affecting collagen of the biological meshes once implanted into a living organism. In this regard, the advantages and limitations of Raman spectroscopy, in the clinical setting, have been recently reviewed 32 .…”

mentioning

confidence: 99%

Bridging repair of the abdominal wall in a rat experimental model. Comparison between uncoated and polyethylene oxide-coated equine pericardium meshes

Pasculli

Gurrado

Luca

et al. 2020

Sci Rep

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Biological meshes improve the outcome of incisional hernia repairs in infected fields but often lead to recurrence after bridging techniques. Sixty male Wistar rats undergoing the excision of an abdominal wall portion and bridging mesh repair were randomised in two groups: Group A (n = 30) using the uncoated equine pericardium mesh; Group B (n = 30) using the polyethylene oxide (PEO)-coated one. No deaths were observed during treatment. Shrinkage was significantly less common in A than in B (3% vs 53%, P < 0.001). Adhesions were the most common complication and resulted significantly higher after 90 days in B than in A (90% vs 30%, P < 0.01). Microscopic examination revealed significantly (p < 0.05) higher mesh integrity, fibrosis and calcification in B compared to A. The enzymatic degradation, as assessed with Raman spectroscopy and enzyme stability test, affected A more than B. the peo-coated equine pericardium mesh showed higher resistance to biodegradation compared to the uncoated one. Understanding the changes of these prostheses in a surgical setting may help to optimize the peo-coating in designing new biomaterials for the bridging repair of the abdominal wall. Incisional hernia affects 10-20% of laparotomies and represents the most common long-term complication after abdominal surgery 1-3. Since their first description by Usher et al. in 1985 4 , synthetic prostheses significantly reduced recurrence rate after the first incisional hernia repair, from more than 20% to less than 10% 5,6. Nevertheless, they are commonly contraindicated in situations in which the exposure to any additional bacterial burden constitutes an excessive risk of surgical site infection 7,8. According to the Ventral Hernia Working Group (VHWG), incisional hernias which are at high risk of surgical site occurrences, because of comorbidities or contamination/infection of the operative field, should be treated using biological meshes; this should also be recommended in those cases in which the complete rectus closure is not possible and bridging technique is unavoidable 9. Although some controversies arose about the influence of technique in determining the surgical site occurrences 10 , and other authors designed and validated other scores 11,12 , VHWG recommendations appear to be still the most reliable guidelines available in the

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“…Furthermore, the wide variety of materials (natural and synthetic) and solvents that can be utilized in electrospinning allows a range of applications to be considered. Subsequently, various material compositions have been explored for delivery drugs [ 28 , 29 , 30 ], antimicrobial agents [ 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 ], chemotherapy [ 39 , 40 , 41 ], and to promote tissue regeneration [ 42 , 43 , 44 , 45 , 46 , 47 ]. For example, Movahedi et al [ 46 ] have produced electrospun aspirin-loaded polycaprolactone (PCL) and maltodextrin composite meshes and observed that the inclusion of aspirin presented better cell adhesion and proliferation in vitro, and faster wound closure in vivo.…”

Section: Introductionmentioning

confidence: 99%

“…For example, Movahedi et al [ 46 ] have produced electrospun aspirin-loaded polycaprolactone (PCL) and maltodextrin composite meshes and observed that the inclusion of aspirin presented better cell adhesion and proliferation in vitro, and faster wound closure in vivo. Alternatively, metallic particles such as silver can be utilized for their antibacterial properties, but also to promote tissue regeneration, for example, Adhikari et al [ 47 ] have electrospun PCL with magnesium particles, which promoted enhanced cell proliferation, vascularization, and healing. Natural materials have also been investigated for their antibacterial attributes and as wound dressings such as using Chelidonium majus L. extract combined with PCL, polyvinyl alcohol, and pectin electrospun meshes [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Characterization of a Polycaprolactone-SurgihoneyRO Electrospun Mesh for Skin Tissue Engineering

et al. 2021

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Skin is a hierarchical and multi-cellular organ exposed to the external environment with a key protective and regulatory role. Wounds caused by disease and trauma can lead to a loss of function, which can be debilitating and even cause death. Accelerating the natural skin healing process and minimizing the risk of infection is a clinical challenge. Electrospinning is a key technology in the development of wound dressings and skin substitutes as it enables extracellular matrix-mimicking fibrous structures and delivery of bioactive materials. Honey is a promising biomaterial for use in skin tissue engineering applications and has antimicrobial properties and potential tissue regenerative properties. This preliminary study investigates a solution electrospun composite nanofibrous mesh based on polycaprolactone and a medical grade honey, SurgihoneyRO. The processing conditions were optimized and assessed by scanning electron microscopy to fabricate meshes with uniform fiber diameters and minimal presence of beads. The chemistry of the composite meshes was examined using Fourier transform infrared spectroscopy and X-ray photon spectroscopy showing incorporation of honey into the polymer matrix. Meshes incorporating honey had lower mechanical properties due to lower polymer content but were more hydrophilic, resulting in an increase in swelling and an accelerated degradation profile. The biocompatibility of the meshes was assessed using human dermal fibroblasts and adipose-derived stem cells, which showed comparable or higher cell metabolic activity and viability for SurgihoneyRO-containing meshes compared to polycaprolactone only meshes. The meshes showed no antibacterial properties in a disk diffusion test due to a lack of hydrogen peroxide production and release. The developed polycaprolactone-honey nanofibrous meshes have potential for use in skin applications.

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Embedding magnesium metallic particles in polycaprolactone nanofiber mesh improves applicability for biomedical applications

Cited by 62 publications

References 89 publications

Investigation of metallic nanoparticle distribution in PAN/magnetic nanocomposites fabricated with needleless electrospinning technique

Investigation of metallic nanoparticle distribution in PAN/magnetic nanocomposites fabricated with needleless electrospinning technique

Bridging repair of the abdominal wall in a rat experimental model. Comparison between uncoated and polyethylene oxide-coated equine pericardium meshes

Preliminary Characterization of a Polycaprolactone-SurgihoneyRO Electrospun Mesh for Skin Tissue Engineering

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