2012
DOI: 10.1111/j.2042-3306.2012.00633.x
|View full text |Cite
|
Sign up to set email alerts
|

Elution of antimicrobials from a cross‐linked dextran gel:In vivoQuantification

Abstract: Cross-linked dextran gel is a safe, effective alternative local antimicrobial delivery method.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
13
0

Year Published

2013
2013
2022
2022

Publication Types

Select...
6
1
1

Relationship

0
8

Authors

Journals

citations
Cited by 10 publications
(13 citation statements)
references
References 31 publications
0
13
0
Order By: Relevance
“…As such, azithromycin is proposed as an appropriate empirical treatment for Rhodococcus equi in the horse, despite being classified as a CIA. In a study published in this issue, workers investigated a novel method for the sustained release of antimicrobials into the joint of horses with synovial sepsis using a dextran gel . The technique is novel, leaves no tissue residues and provides effective antimicrobial concentrations for a prolonged period.…”
mentioning
confidence: 99%
“…As such, azithromycin is proposed as an appropriate empirical treatment for Rhodococcus equi in the horse, despite being classified as a CIA. In a study published in this issue, workers investigated a novel method for the sustained release of antimicrobials into the joint of horses with synovial sepsis using a dextran gel . The technique is novel, leaves no tissue residues and provides effective antimicrobial concentrations for a prolonged period.…”
mentioning
confidence: 99%
“…A biodegradable dextran polymer matrix (Vetrigel, Royer Animal Health, Frederick, Maryland, United States), originally developed for wound management, can also be used to provide sustained antimicrobial delivery. [14][15][16] The product is formed by mixing an oxidized dextran solution with a cross-linking agent and excipients, and has a gel-like consistency. The dextran polymer degrades by hydrolysis in vivo over a 4 to 5-week period.…”
Section: Introductionmentioning
confidence: 99%
“…Poloxamer gels have been combined with a variety of drugs, and provide prolonged drug plasma concentrations when compared with solo drug therapy . Trials suggest that when combined with antibiotic therapies, poloxamer gels hold the antibiotic at the site, releasing the drug slowly …”
Section: Introductionmentioning
confidence: 99%