Elution of antimicrobials from a cross‐linked dextran gel:<i>In vivo</i>Quantification

Hart, Samantha K.; Barrett, Jennifer G.; Brown, James A.; Papich, Mark G.; Powers, B E; Sullins, K. E.

doi:10.1111/j.2042-3306.2012.00633.x

Cited by 10 publications

(13 citation statements)

References 31 publications

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“…As such, azithromycin is proposed as an appropriate empirical treatment for Rhodococcus equi in the horse, despite being classified as a CIA. In a study published in this issue, workers investigated a novel method for the sustained release of antimicrobials into the joint of horses with synovial sepsis using a dextran gel . The technique is novel, leaves no tissue residues and provides effective antimicrobial concentrations for a prolonged period.…”

mentioning

confidence: 99%

Antimicrobial stewardship: Time for change

Bowen

2013

Equine Veterinary Journal

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mentioning

confidence: 99%

Antimicrobial stewardship: Time for change

Bowen

2013

Equine Veterinary Journal

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“…A biodegradable dextran polymer matrix (Vetrigel, Royer Animal Health, Frederick, Maryland, United States), originally developed for wound management, can also be used to provide sustained antimicrobial delivery. [14][15][16] The product is formed by mixing an oxidized dextran solution with a cross-linking agent and excipients, and has a gel-like consistency. The dextran polymer degrades by hydrolysis in vivo over a 4 to 5-week period.…”

Section: Introductionmentioning

confidence: 99%

Intra-articular Injection of a Dextran Polymer Combined with Antibiotic Medications for Bacterial Infective Arthritis in Dogs: 14 Cases

et al. 2021

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Objectives The aim of this study was to describe the use of an intra-articular delivery of a dextran polymer (IADP) for bacterial infective arthritis in dogs. Materials and Methods Cases of bacterial infective arthritis treated with IADP were reviewed. Resolution of infection was based on joint fluid cytology. Lameness scores, total nucleated cell counts, and per cent neutrophils were monitored throughout treatment. Results There were 14 dogs included in the study. The stifle was the most commonly affected joint. The median number of injections per dog was 3 with a median of 2 weeks between injections. Amikacin was combined with the dextran polymer in 13 cases and imipenem was used in 1 case. Concurrent oral antimicrobials were used in 12/14 cases, and surgery for infection was performed in 10/14 cases. Cytological evidence of infection resolved in 11/14 cases. Median lameness scores throughout treatment decreased from severe (grade ¾) at initial presentation to mild (grade ¼) at the final recheck. Median total nucleated cell counts and per cent neutrophils decreased from 40,000 white blood cell/µL and 91% to 2,200 white blood cell/µL and 4% respectively. A transient worsening of lameness was the main side effect documented in 5/14 cases. Conclusion Intra-articular dextran polymer combined with antimicrobials was generally well tolerated; however, the efficacy of IADP was unknown in this population since most dogs received concurrent oral antimicrobials and/or surgery.

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“…Poloxamer gels have been combined with a variety of drugs, and provide prolonged drug plasma concentrations when compared with solo drug therapy . Trials suggest that when combined with antibiotic therapies, poloxamer gels hold the antibiotic at the site, releasing the drug slowly …”

Section: Introductionmentioning

confidence: 99%