2015
DOI: 10.12989/bme.2015.2.3.159
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Elution of amikacin and vancomycin from a calcium sulfate/chitosan bone scaffold

Abstract: Treatment of polymicrobial infected musculoskeletal defects continues to be a challenge in orthopaedics. This research investigated single and dual-delivery of two antibiotics, vancomycin and amikacin, targeting different classes of microorganism from a biodegradable calcium sulfate-chitosan-nHA microsphere composite scaffold. The addition of chitosan-nHA was included to provide additional structure for cellular attachment and as a secondary drug-loading device. All scaffolds exhibited an initial burst of anti… Show more

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