1986
DOI: 10.1002/anie.198610131
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Elucidation of the Structure of Pharmacologically Active Magnesium L‐Aspartate Complexes

Abstract: Magnesium therapy (infact prophylaxis, suppression of stress symptoms etc.) has proven successful on using complexes of magnesium with natural amino and polycarboxylic acids. Presumably their activity is due to formation of weak complexes, from which the magnesium is released again after transport. As has now been demonstrated, L‐aspartic acid reacts as a di‐ to tridentate ligand depending on the pH. On the basis of X‐ray crystallographic, spectroscopic and electrochemical data, a model has been designed which… Show more

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Cited by 33 publications
(7 citation statements)
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“…for HAnthAnthOH (C 14 The preparation follows the procedure described in Section 2.3 with sodium hydroxide (0.160 g, 3.90 mmol). The product separates (as the trihydrate) from the mother liquor in the form of transparent colourless crystals after 5 days; yield: 1.00 g, 77%.…”
Section: Preparation Of (Anthranoyl)anthranilic Acid {2-[(2-aminobenzmentioning
confidence: 99%
See 1 more Smart Citation
“…for HAnthAnthOH (C 14 The preparation follows the procedure described in Section 2.3 with sodium hydroxide (0.160 g, 3.90 mmol). The product separates (as the trihydrate) from the mother liquor in the form of transparent colourless crystals after 5 days; yield: 1.00 g, 77%.…”
Section: Preparation Of (Anthranoyl)anthranilic Acid {2-[(2-aminobenzmentioning
confidence: 99%
“…Due to difficulties in the preparation of crystalline specimen of such complexes [5,7,8], thorough structural investigations have been performed on metal complexes with the anions of a-L L -aspartic acid and a-L L -glutamic acid [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] (Fig. 1) which can serve as models for the binding of metal ions to proteins.…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3] Many of these studies have focused on the use of carboxylate ligands like aspartate, glutamate, salicylic acid and more recently amino and mercaptobenzoates. [4][5][6][7][8][9][10][11][12][13][14] While such studies are important to enhance our understanding of Mg biochemistry, a recent interest in this area is in terms of the rich structural chemistry exhibited by the alkaliearth metal complexes. It is to be noted that the carboxylate group is a versatile ligand and exhibits a variety of binding modes.…”
Section: Introductionmentioning
confidence: 99%
“…This fact, together with the lack of studies of interactions of lead with simple biomolecules, motivated the present work, in which three different lead complexes with proline were obtained. Since lead has a variety of coordination numbers and geometries [7] and since the crystal structures of several metal complexes with aspartate [8][9][10][11][12] show the coordination versatility of this ligand, study of the interaction between lead and amino acids may be useful in understanding the action of metal ions in organisms. Recently complexes of lead(II) with valine, aspartate and nitrate, [Pb(val) 2 (H 2 O) 2 (NO 3 ) 2 ] and [Pb(aspH)(NO 3 )] were reported [13,14].…”
Section: Introductionmentioning
confidence: 99%