“…Zingiber zerumbet (L.) smith or Zingiber aromaticum. It contains three double bonds, two conjugated and one isolated, as well as a conjugated carbonyl group in 11-membrane ring structure [16,17]. Among parts of the plant richest in ZER are rhizomes followed by the leaves [18,19].…”
It has long been established that a diet rich in fresh fruits, vegetables, seeds, grains and legumes and antioxidants, and other beneficial compounds may help prevent various human diseases. However, diet is not a cure for treatment of severe diseases, but it may help prevent some ailments, and it can help the body overcome the effects of conventional treatments. Natural compounds not only serve as a drug or template for drugs but also, in many instances, had been a source of discovery of novel biology that provided better understanding of target and pathway involved in the disease processes. In addition, drugs derived from natural compounds work better for patients than do drugs manufactured synthetically. Approximately, 40% of drugs in the pipeline and 70% of synthetic therapeutic molecules are plagued with poor solubility, oral bioavailability, and delivery. Drugs with poor solubility encounter limited transport during oral administration because of low concentration gradient between the gut and the blood vessels. To increase body fluid saturation solubility of poorly soluble drug, new delivery methods need to be developed using natural dietary plant metabolites.
“…Zingiber zerumbet (L.) smith or Zingiber aromaticum. It contains three double bonds, two conjugated and one isolated, as well as a conjugated carbonyl group in 11-membrane ring structure [16,17]. Among parts of the plant richest in ZER are rhizomes followed by the leaves [18,19].…”
It has long been established that a diet rich in fresh fruits, vegetables, seeds, grains and legumes and antioxidants, and other beneficial compounds may help prevent various human diseases. However, diet is not a cure for treatment of severe diseases, but it may help prevent some ailments, and it can help the body overcome the effects of conventional treatments. Natural compounds not only serve as a drug or template for drugs but also, in many instances, had been a source of discovery of novel biology that provided better understanding of target and pathway involved in the disease processes. In addition, drugs derived from natural compounds work better for patients than do drugs manufactured synthetically. Approximately, 40% of drugs in the pipeline and 70% of synthetic therapeutic molecules are plagued with poor solubility, oral bioavailability, and delivery. Drugs with poor solubility encounter limited transport during oral administration because of low concentration gradient between the gut and the blood vessels. To increase body fluid saturation solubility of poorly soluble drug, new delivery methods need to be developed using natural dietary plant metabolites.
“…The nucleophilic addition of a second cyanide ion to the carbonyl group opens the strained cyclopropanone to generate another carbanion at C11, which displaces the remaining bromine, creating the final cyclopropane ring (13). Acyl cyanide is rapidly hydrolyzed to yield acids 14a and 14b.…”
Section: Double Favorskii Rearrangementmentioning
confidence: 99%
“…The final yield and ee of (þ)-36 were 38% and 89% respectively. 12,13) Consequently, the Sharpless asymmetric epoxidation (with L-DET) of racemic zerumbol 34 gave racemic 2,3-epoxide 36 regioselectively but not enantioselectively. A second in situ epoxidation step led to efficient kinetic resolution of 36 to afford (À)-35 with 99% ee.…”
Section: Sharpless Epoxidation Of Zerumbolmentioning
confidence: 99%
“…[12][13][14][15][16][17] For example, since many useful polycyclic compounds exist in nature, the development of the transannular reaction and the construction of various transannular products are very important in organic and material chemistry. 1 as a natural resource showed good reactivity and could be converted into various structures.…”
Zerumbone is a cyclic seaquiterpene and, a potential resource for natural materials-related diversityoriented synthesis (NMRDOS). Zerumbone, the main component of the essential oil of a wild ginger, Zingiber zerumbet Smith, showed strong reactivity with good chemo-, regio-, and stereoselectivity. To build the foundations for the industrial use of zerumbone, we examined conjugate addition, transannular reactions, ring cleavage, ring expansion, and asymmetric induction. The biological activity of zerumbone derivatives was also studied.
“…It is proposed that the reaction ee proceeds with a diastereoselective but non-enantioselective monoepoxidation at the 2,3-position followed by a second highly enantioselective epoxidation at the 10,11de position giving efficient kinetic resolution. 225 The enantioselective oxidation of β-keto sulfides with TBHP in the presence of a titanium complex with (S,S)-hydrobenzoin is a convenient route to the corresponding β-ketosulfoxides in terms of reaction conditions, yields and enantioselectivities (ee > 98%). Aryl ketosulfoxides on reduction ee with DIBAL-ZnCl 2 yielded the corresponding β-sulfinyl alcohols with a retention of configuration.…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.