Elucidation of the powder flow pattern in a twin-screw LIW-feeder for various refill regimes

Souter, L De; Waeytens, Ruben; Hauwermeiren, Daan Van; Grymonpré, W.; Bekaert, B.; Beer, Thomas De

doi:10.1016/j.ijpharm.2022.122534

Cited by 3 publications

(3 citation statements)

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“…Cohesion has been shown, across multiple studies, to worsen the flowability of powders, in turn reducing the consistency with which powder flows into the conveying volume [ 5 , 43 , 55 ]. The transient inconsistency of material flowing into this volume persists and has been shown to result in turn in an inconsistency in the delivered mass powder flow—and therefore a deviation from the desired set point [ 2 , 41 , 55 , 65 ]. Thus, it is very important to ensure that powder, despite its cohesive nature, is consistently motivated to enter and be transported through the conveying section of the feeder.…”

Section: Powder Feedingmentioning

confidence: 99%

“…This review outlines just a few examples that have been used so far to reduce the negative influence of cohesion on feeding: reducing interparticle contact between cohesive species [ 5 , 57 ]; reducing the effect of triboelectric charging [ 57 ]; refilling the hopper at moderate fill levels [ 41 , 65 ]; and adjusting screw speed and screw type [ 2 , 64 ].…”

Section: Powder Feedingmentioning

confidence: 99%

“…Bridging/arching within the hopper volume has been shown to suffocate the flow of powder into the conveying volume. As a result, both additives and refilling strategy show ideas for reducing the processing variability [ 2 , 41 , 55 , 65 ]. Furthermore, using DEM for complex agitator design would further help the development of arching minimisation.…”

Section: Summary Tablementioning

confidence: 99%

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Reviewing the Impact of Powder Cohesion on Continuous Direct Compression (CDC) Performance

et al. 2023

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The pharmaceutical industry is undergoing a paradigm shift towards continuous processing from batch, where continuous direct compression (CDC) is considered to offer the most straightforward implementation amongst powder processes due to the relatively low number of unit operations or handling steps. Due to the nature of continuous processing, the bulk properties of the formulation will require sufficient flowability and tabletability in order to be processed and transported effectively to and from each unit operation. Powder cohesion presents one of the greatest obstacles to the CDC process as it inhibits powder flow. As a result, there have been many studies investigating potential manners in which to overcome the effects of cohesion with, to date, little consideration of how these controls may affect downstream unit operations. The aim of this literature review is to explore and consolidate this literature, considering the impact of powder cohesion and cohesion control measures on the three-unit operations of the CDC process (feeding, mixing, and tabletting). This review will also cover the consequences of implementing such control measures whilst highlighting subject matter which could be of value for future research to better understand how to manage cohesive powders for CDC manufacture.

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